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Sgo2a shugoshin 2A [ Mus musculus (house mouse) ]

Gene ID: 68549, updated on 12-May-2024

Summary

Official Symbol
Sgo2aprovided by MGI
Official Full Name
shugoshin 2Aprovided by MGI
Primary source
MGI:MGI:1098767
See related
Ensembl:ENSMUSG00000026039 AllianceGenome:MGI:1098767
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sgol2; Sgol2a; Tripin; D1Ertd8e; 1110007N04Rik; 4932411A20Rik; 5730576N04Rik
Summary
Acts upstream of or within meiotic nuclear division; positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric; and protein localization. Located in kinetochore. Is expressed in nervous system and oocyte. Orthologous to human SGO2 (shugoshin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 7.1), placenta adult (RPKM 4.8) and 12 other tissues See more
Orthologs
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Genomic context

See Sgo2a in Genome Data Viewer
Location:
1 C1.3; 1 28.86 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (58024499..58065436)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (57985340..58026277)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated, serine-rich 2-like Neighboring gene STARR-seq mESC enhancer starr_00998 Neighboring gene predicted gene, 57576 Neighboring gene potassium channel tetramerisation domain containing 18 Neighboring gene STARR-positive B cell enhancer ABC_E7730 Neighboring gene STARR-seq mESC enhancer starr_01001 Neighboring gene STARR-seq mESC enhancer starr_01003 Neighboring gene aldehyde oxidase 1 Neighboring gene STARR-seq mESC enhancer starr_01004 Neighboring gene STARR-seq mESC enhancer starr_01005 Neighboring gene predicted gene, 39643 Neighboring gene aldehyde oxidase 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1)  1 citation
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
 
located_in condensed chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
part_of mitotic cohesin complex ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
shugoshin 2
Names
sgo2
shugoshin-like 2
shugoshin-like 2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177867.1NP_001171338.1  shugoshin 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks a few of 5' exons but has an alternate 5' exon, as compared to variant 1. The resulting isoform (2) is shorter and has a different N-terminus, as compared to isoform 1.
    Source sequence(s)
    BC052742, CN716821
    UniProtKB/Swiss-Prot
    Q7TSY8
    Conserved Domains (1) summary
    pfam05539
    Location:35228
    Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G
  2. NM_199007.2NP_950172.1  shugoshin 2 isoform 1

    See identical proteins and their annotated locations for NP_950172.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK042448, AK138621, BC052742
    Consensus CDS
    CCDS35574.1
    UniProtKB/Swiss-Prot
    Q7TSY8, Q811I4, Q8C9C4, Q8CGJ4, Q9CS55
    Related
    ENSMUSP00000027202.9, ENSMUST00000027202.9
    Conserved Domains (1) summary
    pfam05539
    Location:135328
    Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    58024499..58065436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)