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Cherp calcium homeostasis endoplasmic reticulum protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 290614, updated on 5-Mar-2024

Summary

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Official Symbol
Cherpprovided by RGD
Official Full Name
calcium homeostasis endoplasmic reticulum proteinprovided by RGD
Primary source
RGD:1305279
See related
Ensembl:ENSRNOG00000012323 AllianceGenome:RGD:1305279
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable transmembrane transporter binding activity. Predicted to be involved in positive regulation of calcineurin-NFAT signaling cascade and release of sequestered calcium ion into cytosol. Predicted to act upstream of or within negative regulation of cell population proliferation. Located in sarcoplasmic reticulum membrane. Orthologous to human CHERP (calcium homeostasis endoplasmic reticulum protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 72.8), Thymus (RPKM 69.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
16p14
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (17401497..17414549)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (17367455..17380507)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (19068783..19081837)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 26 Neighboring gene uncharacterized LOC134482462 Neighboring gene solute carrier family 35, member E1 Neighboring gene similar to human chromosome 19 open reading frame 44 Neighboring gene calreticulin 3 Neighboring gene epidermal growth factor receptor pathway substrate 15-like 1 Neighboring gene KLF transcription factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning of human Ca2+ homoeostasis endoplasmic reticulum protein (CHERP): regulated expression of antisense cDNA depletes CHERP, inhibits intracellular Ca2+ mobilization and decreases cell proliferation. Laplante JM, et al. Biochem J, 2000 May 15. PMID 10794731, Free PMC Article
  2. Identification of novel ryanodine receptor 1 (RyR1) protein interaction with calcium homeostasis endoplasmic reticulum protein (CHERP). Ryan T, et al. J Biol Chem, 2011 May 13. PMID 21454501, Free PMC Article
  3. Antisense-mediated loss of calcium homoeostasis endoplasmic reticulum protein (CHERP; ERPROT213-21) impairs Ca2+ mobilization, nuclear factor of activated T-cells (NFAT) activation and cell proliferation in Jurkat T-lymphocytes. O'Rourke FA, et al. Biochem J, 2003 Jul 1. PMID 12656674, Free PMC Article
  4. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article
  5. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CHERP is an RyR1 interacting protein that may be involved in the regulation of excitation-contraction coupling
    Title: Identification of novel ryanodine receptor 1 (RyR1) protein interaction with calcium homeostasis endoplasmic reticulum protein (CHERP).
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in sarcoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
calcium homeostasis endoplasmic reticulum protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106064.1 → NP_001099534.1  calcium homeostasis endoplasmic reticulum protein

    See identical proteins and their annotated locations for NP_001099534.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474031
    UniProtKB/TrEMBL
    A0A8I5ZN65, A6K9P2
    Related
    ENSRNOP00000087633.1, ENSRNOT00000110673.1
    Conserved Domains (3) summary
    smart00443
    Location:847 → 897
    G_patch; glycine rich nucleic binding domain
    smart00648
    Location:13 → 65
    SWAP; Suppressor-of-White-APricot splicing regulator
    pfam04818
    Location:212 → 271
    CTD_bind; RNA polymerase II-binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    17401497..17414549
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006252796.5 → XP_006252858.1  calcium homeostasis endoplasmic reticulum protein isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZN65, D3ZAX5
    Related
    ENSRNOP00000017424.6
    Conserved Domains (3) summary
    smart00443
    Location:858 → 908
    G_patch; glycine rich nucleic binding domain
    smart00648
    Location:13 → 65
    SWAP; Suppressor-of-White-APricot splicing regulator
    pfam04818
    Location:212 → 282
    CTD_bind; RNA polymerase II-binding domain

  2. XM_006252797.5 → XP_006252859.1  calcium homeostasis endoplasmic reticulum protein isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZN65
    Conserved Domains (3) summary
    smart00443
    Location:854 → 904
    G_patch; glycine rich nucleic binding domain
    smart00648
    Location:13 → 65
    SWAP; Suppressor-of-White-APricot splicing regulator
    pfam04818
    Location:212 → 282
    CTD_bind; RNA polymerase II-binding domain

  3. XM_039094273.2 → XP_038950201.1  calcium homeostasis endoplasmic reticulum protein isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZN65
    Conserved Domains (4) summary
    PHA03377
    Location:386 → 695
    PHA03377; EBNA-3C; Provisional
    smart00443
    Location:852 → 902
    G_patch; glycine rich nucleic binding domain
    smart00648
    Location:13 → 65
    SWAP; Suppressor-of-White-APricot splicing regulator
    pfam04818
    Location:160 → 286
    CTD_bind; RNA polymerase II-binding domain

  4. XM_039094274.2 → XP_038950202.1  calcium homeostasis endoplasmic reticulum protein isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZN65
    Related
    ENSRNOP00000079307.1
    Conserved Domains (4) summary
    PHA03377
    Location:381 → 690
    PHA03377; EBNA-3C; Provisional
    smart00443
    Location:843 → 893
    G_patch; glycine rich nucleic binding domain
    smart00648
    Location:13 → 65
    SWAP; Suppressor-of-White-APricot splicing regulator
    pfam04818
    Location:160 → 281
    CTD_bind; RNA polymerase II-binding domain
Nucleotide Protein Strain
Heading Accession and Version

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