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VDAC1 voltage dependent anion channel 1 [ Bos taurus (domestic cattle) ]

Gene ID: 282119, updated on 18-Aug-2024

Summary

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Official Symbol
VDAC1provided by VGNC
Official Full Name
voltage dependent anion channel 1provided by VGNC
Primary source
VGNC:VGNC:36782
See related
BGD:BT26720; Ensembl:ENSBTAG00000013113
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See VDAC1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 7 NC_037334.1 (45663910..45690712, complement)

Chromosome 7 - NC_037334.1Genomic Context describing neighboring genes Neighboring gene follistatin like 4 Neighboring gene uncharacterized LOC112447416 Neighboring gene uncharacterized LOC132345820 Neighboring gene chromosome 7 C5orf15 homolog Neighboring gene transcription factor 7 Neighboring gene S-phase kinase associated protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Location of the dicyclohexylcarbodiimide-reactive glutamate residue in the bovine heart mitochondrial porin. De Pinto V, et al. J Biol Chem, 1993 Jun 15. PMID 7685355
  2. Cloning and in situ localization of a brain-derived porin that constitutes a large-conductance anion channel in astrocytic plasma membranes. Dermietzel R, et al. Proc Natl Acad Sci U S A, 1994 Jan 18. PMID 7507248, Free PMC Article
  3. Localisation and function of voltage-dependent anion channels (VDAC) in bovine spermatozoa. Triphan X, et al. Pflugers Arch, 2008 Jan. PMID 17647012
  4. Relationship between expression of voltage-dependent anion channel (VDAC) isoforms and type of hexokinase binding sites on brain mitochondria. Poleti MD, et al. J Mol Neurosci, 2010 May. PMID 19688190
  5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Multiple spots on 2D gel representing VDAC1 protein forms with different isoelectric points.
    Title: Relationship between expression of voltage-dependent anion channel (VDAC) isoforms and type of hexokinase binding sites on brain mitochondria.
  2. Results describe the expression of voltage-dependent anion channel isoforms in rat, bovine, and chicken brain mitochondria, and suggest that the nature of hexokinase binding site is not determined by the expression of a single VDAC isoform.
    Title: Relationship between expression of voltage-dependent anion channel (VDAC) isoforms and type of hexokinase binding sites on brain mitochondria.
  3. Suggest that VDAC1 participates in volume regulatory processes in spermatozoa.
    Title: Localisation and function of voltage-dependent anion channels (VDAC) in bovine spermatozoa.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables voltage-gated monoatomic anion channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in monoatomic anion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
non-selective voltage-gated ion channel VDAC1; voltage-dependent anion-selective channel protein 1
Names
BR1-VDAC
VDAC-1
brain-derived voltage-dependent anion channel 1
plasmalemmal porin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174485.4 → NP_776910.2  non-selective voltage-gated ion channel VDAC1

    See identical proteins and their annotated locations for NP_776910.2

    Status: PROVISIONAL

    Source sequence(s)
    BC102113
    UniProtKB/TrEMBL
    A0AAF6ZJG9
    Related
    ENSBTAP00000017430.4, ENSBTAT00000017430.5
    Conserved Domains (1) summary
    cd07306
    Location:4 → 282
    Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037334.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    45663910..45690712 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024993844.1 → XP_024849612.1  voltage-dependent anion-selective channel protein 1 isoform X2

    UniProtKB/Swiss-Prot
    P45879, Q3ZCK0, Q71SW7
    UniProtKB/TrEMBL
    A0AAF6ZJG9
    Conserved Domains (1) summary
    cd07306
    Location:4 → 282
    Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

  2. XM_005209336.5 → XP_005209393.1  voltage-dependent anion-selective channel protein 1 isoform X2

    See identical proteins and their annotated locations for XP_005209393.1

    UniProtKB/Swiss-Prot
    P45879, Q3ZCK0, Q71SW7
    UniProtKB/TrEMBL
    A0AAF6ZJG9
    Conserved Domains (1) summary
    cd07306
    Location:4 → 282
    Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

  3. XM_059887935.1 → XP_059743918.1  voltage-dependent anion-selective channel protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A3Q1MS21, A0AAF6ZJG9
    Related
    ENSBTAP00000072708.2, ENSBTAT00000075754.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P45879.3 GenPept UniProtKB/Swiss-Prot:P45879

Gene LinkOut

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