ARG2 arginase 2 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: ARG2provided by VGNC
Official Full Name: arginase 2provided by VGNC
Primary source: VGNC:VGNC:26071
See related: BGD:BT20714; Ensembl:ENSBTAG00000001945
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	10	NC_037337.1 (79499746..79534867)

Chromosome 10 - NC_037337.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activity of arginase before and at the time of parturition might be a potential marker for occurrence of metritis, especially in cows that develop retained fetal membranes.
Title: Associations between activity of arginase or matrix metalloproteinase-8 (MMP-8) and metritis in periparturient dairy cattle.
results indicate that arginase induction depends in part on epidermal growth factor (EGF) receptor activity, and that EGFR inhibitors may attenuate vascular remodeling without affecting nitric oxide release
Title: Cytokine-induced endothelial arginase expression is dependent on epidermal growth factor receptor.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables arginase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables manganese ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in arginine catabolic process to ornithine	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: arginase-2, mitochondrial

Names: arginase II; arginase, type II; type II arginase

NP_001017942.2

EC 3.5.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001017942.2 → NP_001017942.2 arginase-2, mitochondrial precursor

Status: VALIDATED

Source sequence(s)

NKLS02000010

UniProtKB/Swiss-Prot

A2VEA1, Q58DL1

UniProtKB/TrEMBL

A0A3Q1MDT2

Related

ENSBTAP00000002529.5, ENSBTAT00000002529.6

Conserved Domains (1) summary

cd09989
Location:26 → 321

Arginase; Arginase family