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    HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 [ Gallus gallus (chicken) ]

    Gene ID: 415367, updated on 6-Jun-2024

    Summary

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    Symbol
    HERC1provided by CGNC
    Full Name
    HECT and RLD domain containing E3 ubiquitin protein ligase family member 1provided by CGNC
    Primary source
    CGNC:2462
    See related
    Ensembl:ENSGALG00010024437
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See HERC1 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    79
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 10 NC_052541.1 (3955162..4050807)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 10 NC_052582.1 (3830065..3925767)

    Chromosome 10 - NC_052541.1Genomic Context describing neighboring genes Neighboring gene calcium and integrin binding family member 2 Neighboring gene TBC1 domain family member 2B Neighboring gene death associated protein kinase 2 Neighboring gene uncharacterized LOC121111658 Neighboring gene F-box and leucine-rich repeat protein 22 Neighboring gene ubiquitin specific peptidase 3 Neighboring gene carbonic anhydrase 12 Neighboring gene RAB8B, member RAS oncogene family Neighboring gene ribosomal protein S27 like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    probable E3 ubiquitin-protein ligase HERC1
    Names
    guanine nucleotide exchange factor p532
    hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
    XP_004943789.2
    XP_040536483.1
    XP_040536484.1
    XP_040536485.1
    XP_040536486.1
    XP_040536488.1
    XP_040536489.1
    XP_040536490.1
    XP_040536491.1
    XP_040536492.1
    XP_040536493.1
    XP_040536494.1
    XP_040562709.1
    XP_040562711.1
    XP_040562712.1
    XP_040562713.1
    XP_040562714.1
    XP_040562715.1
    XP_040562716.1
    XP_040562717.1
    XP_040562718.1
    XP_046781136.1
    XP_413753.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      3955162..4050807
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040706775.2 → XP_040562709.1  probable E3 ubiquitin-protein ligase HERC1 isoform X1

      UniProtKB/TrEMBL
      A0A8V1A1N8
      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4512 → 4880
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2774 → 2817
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3471 → 3509
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2053 → 2210
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3463 → 3814
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_040706778.2 → XP_040562712.1  probable E3 ubiquitin-protein ligase HERC1 isoform X2

      UniProtKB/TrEMBL
      A0A8V1A1N8
      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4511 → 4879
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2774 → 2817
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3470 → 3508
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2053 → 2210
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3462 → 3813
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_040706784.2 → XP_040562718.1  probable E3 ubiquitin-protein ligase HERC1 isoform X8

      UniProtKB/TrEMBL
      A0A8V0ZSG6
      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4494 → 4862
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2774 → 2817
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3453 → 3491
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2053 → 2210
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3445 → 3796
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. XM_040706780.2 → XP_040562714.1  probable E3 ubiquitin-protein ligase HERC1 isoform X4

      UniProtKB/TrEMBL
      A0A8V1A1N8
      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4511 → 4879
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2774 → 2817
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3470 → 3508
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2053 → 2210
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3462 → 3813
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    5. XM_040706781.2 → XP_040562715.1  probable E3 ubiquitin-protein ligase HERC1 isoform X5

      UniProtKB/TrEMBL
      A0A8V1A1N8
      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4505 → 4873
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2774 → 2817
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3464 → 3502
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2053 → 2210
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3456 → 3807
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    6. XM_040706782.2 → XP_040562716.1  probable E3 ubiquitin-protein ligase HERC1 isoform X6

      UniProtKB/TrEMBL
      A0A8V1A557
      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4504 → 4872
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2766 → 2809
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3463 → 3501
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2053 → 2210
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3455 → 3806
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    7. XM_040706779.2 → XP_040562713.1  probable E3 ubiquitin-protein ligase HERC1 isoform X3

      UniProtKB/TrEMBL
      A0A8V1A1N8
      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4511 → 4879
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2773 → 2816
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3470 → 3508
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2052 → 2209
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3462 → 3813
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    8. XM_004943732.5 → XP_004943789.2  probable E3 ubiquitin-protein ligase HERC1 isoform X9

      UniProtKB/TrEMBL
      A0A8V1A1N8
      Related
      ENSGALP00010036432.1, ENSGALT00010059648.1
      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4490 → 4858
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2752 → 2795
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3449 → 3487
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2031 → 2188
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3441 → 3792
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    9. XM_413753.7 → XP_413753.3  probable E3 ubiquitin-protein ligase HERC1 isoform X10

      UniProtKB/TrEMBL
      A0A8V0ZSG6, A0A8V0ZXN4
      Related
      ENSGALP00010036446.1, ENSGALT00010059667.1
      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4472 → 4840
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2752 → 2795
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3431 → 3469
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2031 → 2188
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3423 → 3774
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    10. XM_040706783.2 → XP_040562717.1  probable E3 ubiquitin-protein ligase HERC1 isoform X7

      UniProtKB/TrEMBL
      A0A8V1A1N8
      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4504 → 4872
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2766 → 2809
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3463 → 3501
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2045 → 2202
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3455 → 3806
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    11. XM_040706777.2 → XP_040562711.1  probable E3 ubiquitin-protein ligase HERC1 isoform X1

      UniProtKB/TrEMBL
      A0A8V1A1N8
      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4512 → 4880
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2774 → 2817
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3471 → 3509
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2053 → 2210
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3463 → 3814
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052582.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      3830065..3925767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040680549.2 → XP_040536483.1  probable E3 ubiquitin-protein ligase HERC1 isoform X1

      UniProtKB/TrEMBL
      A0A8V1A1N8
      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4512 → 4880
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2774 → 2817
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3471 → 3509
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2053 → 2210
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3463 → 3814
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_040680551.2 → XP_040536485.1  probable E3 ubiquitin-protein ligase HERC1 isoform X2

      UniProtKB/TrEMBL
      A0A8V1A1N8
      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4511 → 4879
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2774 → 2817
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3470 → 3508
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2053 → 2210
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3462 → 3813
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_040680558.2 → XP_040536492.1  probable E3 ubiquitin-protein ligase HERC1 isoform X8

      UniProtKB/TrEMBL
      A0A8V0ZSG6
      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4494 → 4862
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2774 → 2817
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3453 → 3491
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2053 → 2210
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3445 → 3796
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. XM_040680554.2 → XP_040536488.1  probable E3 ubiquitin-protein ligase HERC1 isoform X4

      UniProtKB/TrEMBL
      A0A8V1A1N8
      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4511 → 4879
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2774 → 2817
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3470 → 3508
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2053 → 2210
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3462 → 3813
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    5. XM_040680555.2 → XP_040536489.1  probable E3 ubiquitin-protein ligase HERC1 isoform X5

      UniProtKB/TrEMBL
      A0A8V1A1N8
      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4505 → 4873
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2774 → 2817
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3464 → 3502
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2053 → 2210
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3456 → 3807
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    6. XM_040680556.2 → XP_040536490.1  probable E3 ubiquitin-protein ligase HERC1 isoform X6

      UniProtKB/TrEMBL
      A0A8V1A557
      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4504 → 4872
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2766 → 2809
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3463 → 3501
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2053 → 2210
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3455 → 3806
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    7. XM_040680552.2 → XP_040536486.1  probable E3 ubiquitin-protein ligase HERC1 isoform X3

      UniProtKB/TrEMBL
      A0A8V1A1N8
      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4511 → 4879
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2773 → 2816
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3470 → 3508
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2052 → 2209
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3462 → 3813
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    8. XM_040680559.2 → XP_040536493.1  probable E3 ubiquitin-protein ligase HERC1 isoform X9

      UniProtKB/TrEMBL
      A0A8V1A1N8
      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4490 → 4858
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2752 → 2795
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3449 → 3487
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2031 → 2188
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3441 → 3792
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    9. XM_040680560.2 → XP_040536494.1  probable E3 ubiquitin-protein ligase HERC1 isoform X10

      UniProtKB/TrEMBL
      A0A8V0ZSG6
      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4472 → 4840
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2752 → 2795
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3431 → 3469
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2031 → 2188
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3423 → 3774
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    10. XM_040680557.2 → XP_040536491.1  probable E3 ubiquitin-protein ligase HERC1 isoform X7

      UniProtKB/TrEMBL
      A0A8V1A1N8
      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4504 → 4872
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2766 → 2809
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3463 → 3501
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2045 → 2202
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3455 → 3806
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    11. XM_040680550.2 → XP_040536484.1  probable E3 ubiquitin-protein ligase HERC1 isoform X1

      UniProtKB/TrEMBL
      A0A8V1A1N8
      Conserved Domains (6) summary
      COG5184
      Location:374 → 731
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      cd00078
      Location:4512 → 4880
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd14401
      Location:2774 → 2817
      UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
      sd00039
      Location:3471 → 3509
      7WD40; WD40 repeat [structural motif]
      cd12881
      Location:2053 → 2210
      SPRY_HERC1; SPRY domain in HERC1
      cl29593
      Location:3463 → 3814
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    12. XM_046925180.1 → XP_046781136.1  probable E3 ubiquitin-protein ligase HERC1 isoform X1

      UniProtKB/TrEMBL
      A0A8V1A1N8
    Nucleotide Protein Strain
    Heading Accession and Version

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