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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
Genomic
-
NG_046958.1 RefSeqGene
- Range
-
5002..230332
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_003922.4 → NP_003913.3 probable E3 ubiquitin-protein ligase HERC1
See identical proteins and their annotated locations for NP_003913.3
Status: REVIEWED
- Source sequence(s)
-
AK226162, BQ216911, DB117652, U50078
- Consensus CDS
-
CCDS45277.1
- UniProtKB/Swiss-Prot
-
Q15751
- UniProtKB/TrEMBL
-
A0A024R5W0
- Related
- ENSP00000390158.2, ENST00000443617.7
- Conserved Domains (9) summary
-
- smart00119
Location:4504 → 4837
- HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
- COG2319
Location:3394 → 3778
- WD40; WD40 repeat [General function prediction only]
- cd00078
Location:4473 → 4841
- HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
- cd14401
Location:2753 → 2796
- UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
- pfam00415
Location:4309 → 4358
- RCC1; Regulator of chromosome condensation (RCC1) repeat
- pfam13540
Location:667 → 696
- RCC1_2; Regulator of chromosome condensation (RCC1) repeat
- sd00039
Location:3432 → 3475
- 7WD40; WD40 repeat [structural motif]
- cd12881
Location:2032 → 2189
- SPRY_HERC1; SPRY domain in HERC1
- cl02567
Location:3424 → 3775
- WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...