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Herc1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 [ Mus musculus (house mouse) ]

Gene ID: 235439, updated on 12-May-2024

Summary

Official Symbol
Herc1provided by MGI
Official Full Name
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1provided by MGI
Primary source
MGI:MGI:2384589
See related
Ensembl:ENSMUSG00000038664 AllianceGenome:MGI:2384589
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
tbl; B230218H07; 2810449H11Rik; D130015N03Rik
Summary
Acts upstream of or within negative regulation of autophagy; neuromuscular process controlling balance; and neuron differentiation. Is expressed in several structures, including jaw bone; nervous system; sensory organ; thymus primordium; and vibrissa. Orthologous to human HERC1 (HECT and RLD domain containing E3 ubiquitin protein ligase family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 13.0), CNS E14 (RPKM 11.8) and 28 other tissues See more
Orthologs
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Genomic context

See Herc1 in Genome Data Viewer
Location:
9 C; 9 35.86 cM
Exon count:
78
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (66257694..66416057)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (66350412..66508775)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24478 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66128344-66128644 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:66129452-66129653 Neighboring gene STARR-positive B cell enhancer ABC_E2899 Neighboring gene ribosomal protein S27 pseudogene Neighboring gene predicted gene, 39364 Neighboring gene STARR-positive B cell enhancer ABC_E6759 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66213808-66214109 Neighboring gene predicted gene, 30447 Neighboring gene predicted gene, 50499 Neighboring gene predicted gene, 23428 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66312941-66313241 Neighboring gene STARR-positive B cell enhancer ABC_E3841 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66351571-66351871 Neighboring gene F-box and leucine-rich repeat protein 22 Neighboring gene ubiquitin specific peptidase 3 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66440763-66441064 Neighboring gene STARR-positive B cell enhancer mm9_chr9:66444915-66445215 Neighboring gene STARR-positive B cell enhancer ABC_E2900 Neighboring gene STARR-seq mESC enhancer starr_24480 Neighboring gene STARR-positive B cell enhancer ABC_E11413 Neighboring gene carbonic anhydrase 12

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (7) 
  • Gene trapped (1) 
  • Spontaneous (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
probable E3 ubiquitin-protein ligase HERC1
Names
hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1
NP_663592.3
XP_006511166.1
XP_006511167.1
XP_006511168.1
XP_006511169.1
XP_006511170.1
XP_006511171.1
XP_030100191.1
XP_030100192.1
XP_030100193.1
XP_030100194.1
XP_030100195.1
XP_036010796.1
XP_036010797.1
XP_036010798.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145617.3NP_663592.3  probable E3 ubiquitin-protein ligase HERC1

    Status: VALIDATED

    Source sequence(s)
    AC161382, AC166755
    Consensus CDS
    CCDS52840.1
    UniProtKB/TrEMBL
    E9PZP8
    Related
    ENSMUSP00000044801.7, ENSMUST00000042824.13
    Conserved Domains (9) summary
    smart00119
    Location:45024835
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    COG2319
    Location:33923776
    WD40; WD40 repeat [General function prediction only]
    cd00078
    Location:44714839
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:27512794
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    pfam00415
    Location:40984147
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:42914320
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat
    sd00039
    Location:35843622
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:20302187
    SPRY_HERC1; SPRY domain in HERC1
    cl02567
    Location:34223773
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    66257694..66416057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511103.3XP_006511166.1  probable E3 ubiquitin-protein ligase HERC1 isoform X1

    Conserved Domains (6) summary
    COG5184
    Location:374731
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:44974865
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:27602803
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:36103648
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:20392196
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:34483799
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_006511108.3XP_006511171.1  probable E3 ubiquitin-protein ligase HERC1 isoform X9

    Conserved Domains (6) summary
    COG5184
    Location:374731
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:44804848
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:27602803
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:35933631
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:20392196
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:34313782
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_006511105.3XP_006511168.1  probable E3 ubiquitin-protein ligase HERC1 isoform X3

    Conserved Domains (6) summary
    COG5184
    Location:374731
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:44904858
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:27602803
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:36033641
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:20392196
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:34413792
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  4. XM_036154904.1XP_036010797.1  probable E3 ubiquitin-protein ligase HERC1 isoform X10

    Conserved Domains (6) summary
    COG5184
    Location:374731
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:44734841
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:27602803
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:35863624
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:20392196
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:34243775
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. XM_006511106.3XP_006511169.1  probable E3 ubiquitin-protein ligase HERC1 isoform X4

    Conserved Domains (6) summary
    COG5184
    Location:374731
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:44894857
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:27522795
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:36023640
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:20392196
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:34403791
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  6. XM_006511104.3XP_006511167.1  probable E3 ubiquitin-protein ligase HERC1 isoform X2

    Conserved Domains (6) summary
    COG5184
    Location:374731
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:44964864
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:27592802
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:36093647
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:20382195
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:34473798
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  7. XM_030244331.1XP_030100191.1  probable E3 ubiquitin-protein ligase HERC1 isoform X6

    Conserved Domains (6) summary
    COG5184
    Location:374731
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:44884856
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:27512794
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:36013639
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:20382195
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:34393790
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  8. XM_006511107.3XP_006511170.1  probable E3 ubiquitin-protein ligase HERC1 isoform X5

    Conserved Domains (6) summary
    COG5184
    Location:374731
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:44884856
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:27512794
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:36013639
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:20302187
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:34393790
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  9. XM_036154903.1XP_036010796.1  probable E3 ubiquitin-protein ligase HERC1 isoform X8

    Conserved Domains (6) summary
    COG5184
    Location:374731
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:44804848
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:27432786
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:35933631
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:20302187
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:34313782
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  10. XM_030244332.1XP_030100192.1  probable E3 ubiquitin-protein ligase HERC1 isoform X7

    Conserved Domains (6) summary
    COG5184
    Location:374731
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:44874855
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:27502793
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:36003638
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:20292186
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:34383789
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  11. XM_036154905.1XP_036010798.1  probable E3 ubiquitin-protein ligase HERC1 isoform X12

    Conserved Domains (6) summary
    COG5184
    Location:26613009
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:31363504
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:13991442
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:22492287
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:678835
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:20872438
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  12. XM_030244335.2XP_030100195.1  probable E3 ubiquitin-protein ligase HERC1 isoform X13

    Conserved Domains (6) summary
    COG5184
    Location:26603008
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:31353503
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:13981441
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:22482286
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:677834
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:20862437
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  13. XM_030244334.2XP_030100194.1  probable E3 ubiquitin-protein ligase HERC1 isoform X12

    Conserved Domains (6) summary
    COG5184
    Location:26613009
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:31363504
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:13991442
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:22492287
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:678835
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:20872438
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  14. XM_030244333.1XP_030100193.1  probable E3 ubiquitin-protein ligase HERC1 isoform X11

    Conserved Domains (6) summary
    COG5184
    Location:26703018
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:31453513
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:14081451
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:22582296
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:687844
    SPRY_HERC1; SPRY domain in HERC1
    cl29593
    Location:20962447
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_001778881.3 RNA Sequence