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    carmil3 capping protein regulator and myosin 1 linker 3 [ Danio rerio (zebrafish) ]

    Gene ID: 100537031, updated on 25-Apr-2024

    Summary

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    Official Symbol
    carmil3provided by ZNC
    Official Full Name
    capping protein regulator and myosin 1 linker 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070912-183
    See related
    Ensembl:ENSDARG00000086990 AllianceGenome:ZFIN:ZDB-GENE-070912-183
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    lrrc16b; si:ch211-204d18.1
    Summary
    Predicted to be located in cytoplasm and plasma membrane. Is expressed in brain; eye; gut; heart; and spinal cord. Orthologous to human CARMIL3 (capping protein regulator and myosin 1 linker 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See carmil3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (38742338..38890677)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (38776699..38925038)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing protein 16-like Neighboring gene grass carp reovirus (GCRV)-induced gene 2q Neighboring gene si:ch211-119o8.4 Neighboring gene RAS (RAD and GEM)-like GTP binding 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. CARMIL3 is important for cell migration and morphogenesis during early development in zebrafish. Stark BC, et al. Dev Biol, 2022 Jan. PMID 34599906, Free PMC Article
    2. Differential expression of CARMIL-family genes during zebrafish development. Stark BC, et al. Cytoskeleton (Hoboken), 2015 Oct. PMID 26426389, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CARMIL3 is important for cell migration and morphogenesis during early development in zebrafish.
      Title: CARMIL3 is important for cell migration and morphogenesis during early development in zebrafish.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within Kupffer's vesicle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within determination of heart left/right asymmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    capping protein, Arp2/3 and myosin-I linker protein 3
    Names
    leucine rich repeat containing 16B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317765.1 → NP_001304694.1  capping protein, Arp2/3 and myosin-I linker protein 3

      Status: PROVISIONAL

      Source sequence(s)
      KR912200
      UniProtKB/TrEMBL
      A0A0P0CP42, A0A8M1P7B6
      Related
      ENSDARP00000144560.1, ENSDART00000177290.2
      Conserved Domains (4) summary
      cd00116
      Location:367 → 629
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:578 → 599
      LRR_RI; leucine-rich repeat [structural motif]
      sd00034
      Location:311 → 342
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:783 → 1039
      CARMIL_C; CARMIL C-terminus

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      38742338..38890677
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003197917.5 → XP_003197965.2  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8M1RSC9
      Conserved Domains (3) summary
      cd00116
      Location:367 → 629
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:311 → 342
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:783 → 1039
      CARMIL_C; CARMIL C-terminus

    2. XM_021478603.1 → XP_021334278.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q4H0
      Conserved Domains (4) summary
      sd00034
      Location:254 → 285
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam16000
      Location:726 → 982
      CARMIL_C; CARMIL C-terminus
      cl26161
      Location:310 → 572
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cl27975
      Location:1073 → 1305
      EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394507.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      94993..238885
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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