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CARMIL3 capping protein regulator and myosin 1 linker 3 [ Homo sapiens (human) ]

Gene ID: 90668, updated on 17-Jun-2024

Summary

Official Symbol
CARMIL3provided by HGNC
Official Full Name
capping protein regulator and myosin 1 linker 3provided by HGNC
Primary source
HGNC:HGNC:20272
See related
Ensembl:ENSG00000186648 MIM:614716; AllianceGenome:HGNC:20272
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
crml-1; LRRC16B; C14orf121
Summary
Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in skin (RPKM 2.9), brain (RPKM 2.8) and 19 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See CARMIL3 in Genome Data Viewer
Location:
14q11.2
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (24052009..24069729)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (18250326..18268045)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24521218..24538938)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5614 Neighboring gene dehydrogenase/reductase 4 like 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8182 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5615 Neighboring gene dehydrogenase/reductase 4 like 1 (pseudogene) Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5616 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8183 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5617 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5619 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5618 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24521876-24522575 Neighboring gene uncharacterized LOC105370412 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8184 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:24544925-24546124 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8185 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5620 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5621 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24551461-24552375 Neighboring gene copine 6 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:24558209-24558708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8186 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5622 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:24563543-24564192 Neighboring gene neural retina leucine zipper Neighboring gene phosphoenolpyruvate carboxykinase 2, mitochondrial

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
capping protein, Arp2/3 and myosin-I linker protein 3
Names
capping protein regulator and myosin 1 linker protein 3
leucine rich repeat containing 16B
leucine-rich repeat-containing protein 16B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138360.4NP_612369.3  capping protein, Arp2/3 and myosin-I linker protein 3

    See identical proteins and their annotated locations for NP_612369.3

    Status: VALIDATED

    Source sequence(s)
    AI017934, AK074167, AL136295, AL834197, BC008134, BG913168, BU102125, DA121863, DT932621
    Consensus CDS
    CCDS32054.1
    UniProtKB/Swiss-Prot
    Q8ND23, Q8TEF7, Q96HS9
    Related
    ENSP00000340467.5, ENST00000342740.6
    Conserved Domains (4) summary
    cd00116
    Location:339600
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:275303
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:245273
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam16000
    Location:7781063
    CARMIL_C; CARMIL C-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    24052009..24069729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431880.1XP_047287836.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X1

  2. XM_047431882.1XP_047287838.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X3

  3. XM_047431883.1XP_047287839.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X4

  4. XM_047431885.1XP_047287841.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X6

  5. XM_047431887.1XP_047287843.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X8

  6. XM_047431889.1XP_047287845.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X10

  7. XM_047431891.1XP_047287847.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X12

  8. XM_047431881.1XP_047287837.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X2

  9. XM_047431884.1XP_047287840.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X5

  10. XM_047431886.1XP_047287842.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X7

  11. XM_047431888.1XP_047287844.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X9

  12. XM_047431890.1XP_047287846.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X11

  13. XM_047431892.1XP_047287848.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X13

  14. XM_047431893.1XP_047287849.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X14

  15. XM_047431896.1XP_047287852.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X17

  16. XM_047431894.1XP_047287850.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X15

  17. XM_047431895.1XP_047287851.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X16

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654722.1 Reference GRCh38.p14 PATCHES

    Range
    352987..370707
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332354.1XP_054188329.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X3

  2. XM_054332357.1XP_054188332.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X6

  3. XM_054332361.1XP_054188336.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X10

  4. XM_054332363.1XP_054188338.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X12

  5. XM_054332358.1XP_054188333.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X7

  6. XM_054332362.1XP_054188337.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X11

  7. XM_054332365.1XP_054188340.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X14

  8. XM_054332352.1XP_054188327.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X1

  9. XM_054332355.1XP_054188330.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X4

  10. XM_054332359.1XP_054188334.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X8

  11. XM_054332353.1XP_054188328.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X2

  12. XM_054332356.1XP_054188331.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X5

  13. XM_054332360.1XP_054188335.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X9

  14. XM_054332364.1XP_054188339.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X13

  15. XM_054332368.1XP_054188343.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X17

  16. XM_054332366.1XP_054188341.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X15

  17. XM_054332367.1XP_054188342.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X16

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    18250326..18268045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376928.1XP_054232903.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X3

  2. XM_054376931.1XP_054232906.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X6

  3. XM_054376935.1XP_054232910.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X10

  4. XM_054376937.1XP_054232912.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X12

  5. XM_054376932.1XP_054232907.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X7

  6. XM_054376936.1XP_054232911.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X11

  7. XM_054376939.1XP_054232914.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X14

  8. XM_054376926.1XP_054232901.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X1

  9. XM_054376929.1XP_054232904.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X4

  10. XM_054376933.1XP_054232908.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X8

  11. XM_054376927.1XP_054232902.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X2

  12. XM_054376930.1XP_054232905.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X5

  13. XM_054376934.1XP_054232909.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X9

  14. XM_054376938.1XP_054232913.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X13

  15. XM_054376942.1XP_054232917.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X17

  16. XM_054376940.1XP_054232915.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X15

  17. XM_054376941.1XP_054232916.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X16