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    TAF6 TATA-box binding protein associated factor 6 [ Homo sapiens (human) ]

    Gene ID: 6878, updated on 6-Jun-2024

    Summary

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    Official Symbol
    TAF6provided by HGNC
    Official Full Name
    TATA-box binding protein associated factor 6provided by HGNC
    Primary source
    HGNC:HGNC:11540
    See related
    Ensembl:ENSG00000106290 MIM:602955; AllianceGenome:HGNC:11540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ALYUS; TAF2E; TAFII70; TAFII80; TAFII85; MGC:8964; TAFII-70; TAFII-80; TAF(II)70; TAF(II)80
    Summary
    Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
    Expression
    Ubiquitous expression in testis (RPKM 19.4), endometrium (RPKM 14.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TAF6 in Genome Data Viewer
    Location:
    7q22.1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (100107070..100127171, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (101346916..101367060, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99704693..99717481, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99693124-99693624 Neighboring gene microRNA 106b Neighboring gene minichromosome maintenance complex component 7 Neighboring gene microRNA 93 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18415 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99698720-99699272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26336 Neighboring gene adaptor related protein complex 4 subunit mu 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99704970-99705470 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:99708249-99708476 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26337 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26338 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26339 Neighboring gene canopy FGF signaling regulator 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99723160-99723829 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26340 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18416 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18417 Neighboring gene metallo-beta-lactamase domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26341 Neighboring gene ribosomal protein L7 pseudogene 60 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99745544-99746156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26342 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26343 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99746769-99747381 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The third family with TAF6-related phenotype: Alazami-Yuan syndrome. Tuc E, et al. Clin Genet, 2020 May. PMID 32030742
    2. Alternative splicing of TAF6: downstream transcriptome impacts and upstream RNA splice control elements. Kamtchueng C, et al. PLoS One, 2014. PMID 25025302, Free PMC Article
    3. Specific in vitro interaction between papillomavirus E2 proteins and TBP-associated factors. Carrillo E, et al. Intervirology, 2004. PMID 15564746
    4. Discussion paper: experimental and clinical immunopharmacology data applicable to cancer immunotherapy. Mathé G, et al. Ann N Y Acad Sci, 1976. PMID 826207
    5. Identification of hTAF(II)80 delta links apoptotic signaling pathways to transcription factor TFIID function. Bell B, et al. Mol Cell, 2001 Sep. PMID 11583621

    See all (129) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The third family with TAF6-related phenotype: Alazami-Yuan syndrome.
      Title: The third family with TAF6-related phenotype: Alazami-Yuan syndrome.
    2. BIM and NOXA contribute to TAF6delta-dependent cell death.
      Title: BIM and NOXA are mitochondrial effectors of TAF6δ-driven apoptosis.
    3. data point to several new RNA elements that can modulate TAF6delta and also reveal a role for RNA secondary structure in the selection of TAF6delta
      Title: Alternative splicing of TAF6: downstream transcriptome impacts and upstream RNA splice control elements.
    4. TFIID TAF6-TAF9 complex formation involves the HEAT repeat-containing C-terminal domain of TAF6 and is modulated by TAF5 protein.
      Title: TFIID TAF6-TAF9 complex formation involves the HEAT repeat-containing C-terminal domain of TAF6 and is modulated by TAF5 protein.
    5. The transcriptome data uncovered novel links between TAF6delta expression and the Notch, oxidative stress response, integrin, p53, p53 feedback loop 2, and angiogenesis pathways.
      Title: TAF6delta orchestrates an apoptotic transcriptome profile and interacts functionally with p53.
    6. TAF6delta has a pivotal node in a signaling pathway that controls gene expression programs and apoptosis in the absence of p53
      Title: TAF6delta controls apoptosis and gene expression in the absence of p53.
    7. a novel protein-protein interaction was observed between TAFII70 (not TAFII80) and GADD45a
      Title: TAFII70 isoform-specific growth suppression correlates with its ability to complex with the GADD45a protein.
    8. histone fold domain mediated interaction enhances the DNA binding activity of each of the TAF6-TAF9 and TAF4b-TAF12 pairs and of a histone-like octamer complex composed of the four TAFs
      Title: Core promoter binding by histone-like TAF complexes.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Alazami-Yuan syndrome
    MedGen: C4310702 OMIM: 617126 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro PubMed
    tat HIV-1 Tat binds, through amino acids 36-50, directly to the TBP subunit of the TFIID holoenzyme complex (which includes at least TFIID subunits p250, p125, p70, TBP, and p30), and increases the interaction of TFIID with the HIV-1 LTR promoter PubMed
    tat TFIID subunit TAF6 binds to the TATA box and adjacent sequences (including E-box) of HIV-1 LTR, which contains nucleotides from -33 to -16 with respect to the transcriptional start site PubMed
    tat TATA binding protein (TBP)-associated factors (TAFs) in the TFIID complex are required for activation by transcription factors, but are dispensable for HIV-1 Tat LTR transactivation function PubMed
    tat Interaction of TFIID with the HIV-1 LTR, and therefore presumably HIV-1 Tat protein, is primarily dependent on the LTR TATA element and may also be stabilized or regulated by flanking E box motifs and basic helix-loop-helix proteins such as AP-4 and E47 PubMed
    tat A novel function of LBP-1, restricting HIV-1 transcription at the level of elongation by preventing the binding of TFIID to the promoter, is suppressed by HIV-1 Tat, indicating Tat helps recruit TFIID to the HIV-1 LTR PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp781E21155

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase II general transcription initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II general transcription initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aryl hydrocarbon receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in RNA polymerase II preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA polymerase II preinitiation complex assembly IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in RNA polymerase II preinitiation complex assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription initiation by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MLL1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SAGA complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of SLIK (SAGA-like) complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus EXP
    Inferred from Experiment
    more info
    		 PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIID complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIID complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of transcription factor TFIID complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of transcription factor TFTC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFTC complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription initiation factor TFIID subunit 6
    Names
    RNA polymerase II TBP-associated factor subunit E
    TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
    TATA box binding protein (TBP)-associated factor, RNA polymerase II, E, 70/85kD
    transcription initiation factor TFIID 70 kDa subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029454.2 RefSeqGene

      Range
      12813..25101
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001190415.2 → NP_001177344.1  transcription initiation factor TFIID subunit 6 isoform epsilon

      See identical proteins and their annotated locations for NP_001177344.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (epsilon) has a distinct N-terminus and is longer than isoform alpha.
      Source sequence(s)
      AK300005, CX782724, DC339989
      Consensus CDS
      CCDS55135.1
      UniProtKB/TrEMBL
      J3KR72
      Related
      ENSP00000399982.2, ENST00000437822.6
      Conserved Domains (1) summary
      cd08050
      Location:52 → 425
      TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

    2. NM_001364998.1 → NP_001351927.1  transcription initiation factor TFIID subunit 6 isoform alpha

      Status: REVIEWED

      Source sequence(s)
      AC073842
      Consensus CDS
      CCDS5686.1
      UniProtKB/Swiss-Prot
      A4D2B2, A4D2B3, B4DT11, D6W5U2, P49848, Q6AI29
      UniProtKB/TrEMBL
      A0A8I5KRU1
      Related
      ENSP00000509041.1, ENST00000692466.1
      Conserved Domains (2) summary
      COG5095
      Location:9 → 408
      TAF6; Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) [Transcription]
      cd08050
      Location:214 → 430
      TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

    3. NM_001364999.1 → NP_001351928.1  transcription initiation factor TFIID subunit 6 isoform alpha

      Status: REVIEWED

      Source sequence(s)
      AC073842
      Consensus CDS
      CCDS5686.1
      UniProtKB/Swiss-Prot
      A4D2B2, A4D2B3, B4DT11, D6W5U2, P49848, Q6AI29
      UniProtKB/TrEMBL
      A0A8I5KRU1
      Related
      ENSP00000509335.1, ENST00000692927.1
      Conserved Domains (2) summary
      COG5095
      Location:9 → 408
      TAF6; Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) [Transcription]
      cd08050
      Location:214 → 430
      TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

    4. NM_001365000.1 → NP_001351929.1  transcription initiation factor TFIID subunit 6 isoform delta

      Status: REVIEWED

      Source sequence(s)
      AC073842
      Consensus CDS
      CCDS94153.1
      UniProtKB/TrEMBL
      A0A8I5KRU1, A4D299
      Related
      ENSP00000508788.1, ENST00000692408.1
      Conserved Domains (1) summary
      cd08050
      Location:15 → 378
      TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

    5. NM_001365001.1 → NP_001351930.1  transcription initiation factor TFIID subunit 6 isoform delta

      Status: REVIEWED

      Source sequence(s)
      AC073842
      Consensus CDS
      CCDS94153.1
      UniProtKB/TrEMBL
      A0A8I5KRU1, A4D299
      Related
      ENSP00000509320.1, ENST00000691010.1
      Conserved Domains (1) summary
      cd08050
      Location:15 → 378
      TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

    6. NM_001365002.1 → NP_001351931.1  transcription initiation factor TFIID subunit 6 isoform delta

      Status: REVIEWED

      Source sequence(s)
      AC073842
      Consensus CDS
      CCDS94153.1
      UniProtKB/TrEMBL
      A0A8I5KRU1, A4D299
      Related
      ENSP00000509741.1, ENST00000687672.1
      Conserved Domains (1) summary
      cd08050
      Location:15 → 378
      TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

    7. NM_001365003.1 → NP_001351932.1  transcription initiation factor TFIID subunit 6 isoform delta

      Status: REVIEWED

      Source sequence(s)
      AC073842
      Consensus CDS
      CCDS94153.1
      UniProtKB/TrEMBL
      A0A8I5KRU1, A4D299
      Related
      ENSP00000509821.1, ENST00000690367.1
      Conserved Domains (1) summary
      cd08050
      Location:15 → 378
      TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

    8. NM_001365004.1 → NP_001351933.1  transcription initiation factor TFIID subunit 6 isoform zeta

      Status: REVIEWED

      Source sequence(s)
      AC073842
      UniProtKB/TrEMBL
      A0A8I5KRU1
      Conserved Domains (1) summary
      cd08050
      Location:61 → 434
      TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

    9. NM_005641.4 → NP_005632.1  transcription initiation factor TFIID subunit 6 isoform alpha

      See identical proteins and their annotated locations for NP_005632.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform alpha. Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      CX782724, DA707589, L25444
      Consensus CDS
      CCDS5686.1
      UniProtKB/Swiss-Prot
      A4D2B2, A4D2B3, B4DT11, D6W5U2, P49848, Q6AI29
      UniProtKB/TrEMBL
      A0A8I5KRU1
      Related
      ENSP00000344537.4, ENST00000344095.8
      Conserved Domains (2) summary
      COG5095
      Location:9 → 408
      TAF6; Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) [Transcription]
      cd08050
      Location:214 → 430
      TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

    10. NM_139315.3 → NP_647476.1  transcription initiation factor TFIID subunit 6 isoform alpha

      See identical proteins and their annotated locations for NP_647476.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (alpha).
      Source sequence(s)
      BC018115, CX782724, DA150478, DA776355
      Consensus CDS
      CCDS5686.1
      UniProtKB/Swiss-Prot
      A4D2B2, A4D2B3, B4DT11, D6W5U2, P49848, Q6AI29
      UniProtKB/TrEMBL
      A0A8I5KRU1
      Related
      ENSP00000389575.2, ENST00000453269.7
      Conserved Domains (2) summary
      COG5095
      Location:9 → 408
      TAF6; Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) [Transcription]
      cd08050
      Location:214 → 430
      TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

    RNA

    1. NR_033792.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) has a different 5'-most exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to inhibit the translation of the downstream primary ORF, as found in variant 1.
      Source sequence(s)
      AC073842, BC018115, CX782724, DA707589
      Related
      ENST00000684938.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      100107070..100127171 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420781.1 → XP_047276737.1  transcription initiation factor TFIID subunit 6 isoform X2

      UniProtKB/TrEMBL
      A0A8I5KRU1, A4D299

    2. XM_024446896.2 → XP_024302664.1  transcription initiation factor TFIID subunit 6 isoform X1

      UniProtKB/Swiss-Prot
      A4D2B2, A4D2B3, B4DT11, D6W5U2, P49848, Q6AI29
      UniProtKB/TrEMBL
      A0A8I5KRU1
      Related
      ENSP00000508432.1, ENST00000687137.1
      Conserved Domains (2) summary
      COG5095
      Location:9 → 408
      TAF6; Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) [Transcription]
      cd08050
      Location:214 → 430
      TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

    3. XM_047420780.1 → XP_047276736.1  transcription initiation factor TFIID subunit 6 isoform X2

      UniProtKB/TrEMBL
      A0A8I5KRU1, A4D299

    4. XM_047420779.1 → XP_047276735.1  transcription initiation factor TFIID subunit 6 isoform X1

      UniProtKB/Swiss-Prot
      A4D2B2, A4D2B3, B4DT11, D6W5U2, P49848, Q6AI29
      UniProtKB/TrEMBL
      A0A8I5KRU1

    5. XM_024446899.2 → XP_024302667.1  transcription initiation factor TFIID subunit 6 isoform X3

      UniProtKB/TrEMBL
      J3KR72
      Conserved Domains (1) summary
      cd08050
      Location:64 → 437
      TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

    6. XM_011516543.4 → XP_011514845.1  transcription initiation factor TFIID subunit 6 isoform X2

      See identical proteins and their annotated locations for XP_011514845.1

      UniProtKB/TrEMBL
      A0A8I5KRU1, A4D299
      Conserved Domains (1) summary
      cd08050
      Location:15 → 378
      TAF6; TATA Binding Protein (TBP) Associated Factor 6 (TAF6) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

    7. XM_024446900.2 → XP_024302668.1  transcription initiation factor TFIID subunit 6 isoform X1

      UniProtKB/Swiss-Prot
      A4D2B2, A4D2B3, B4DT11, D6W5U2, P49848, Q6AI29
      UniProtKB/TrEMBL
      A0A8I5KRU1
      Conserved Domains (2) summary
      COG5095
      Location:9 → 408
      TAF6; Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) [Transcription]
      cd08050
      Location:214 → 430
      TAF6C; C-terminal domain of TATA Binding Protein (TBP) Associated Factor 6 (TAF6)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      101346916..101367060 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358900.1 → XP_054214875.1  transcription initiation factor TFIID subunit 6 isoform X1

      UniProtKB/Swiss-Prot
      A4D2B2, A4D2B3, B4DT11, D6W5U2, P49848, Q6AI29
      UniProtKB/TrEMBL
      A0A8I5KRU1

    2. XM_054358898.1 → XP_054214873.1  transcription initiation factor TFIID subunit 6 isoform X1

      UniProtKB/Swiss-Prot
      A4D2B2, A4D2B3, B4DT11, D6W5U2, P49848, Q6AI29
      UniProtKB/TrEMBL
      A0A8I5KRU1

    3. XM_054358899.1 → XP_054214874.1  transcription initiation factor TFIID subunit 6 isoform X2

      UniProtKB/TrEMBL
      A0A8I5KRU1, A4D299

    4. XM_054358901.1 → XP_054214876.1  transcription initiation factor TFIID subunit 6 isoform X2

      UniProtKB/TrEMBL
      A0A8I5KRU1, A4D299

    5. XM_054358902.1 → XP_054214877.1  transcription initiation factor TFIID subunit 6 isoform X3

      UniProtKB/TrEMBL
      J3KR72

    6. XM_054358904.1 → XP_054214879.1  transcription initiation factor TFIID subunit 6 isoform X2

      UniProtKB/TrEMBL
      A0A8I5KRU1, A4D299

    7. XM_054358903.1 → XP_054214878.1  transcription initiation factor TFIID subunit 6 isoform X1

      UniProtKB/Swiss-Prot
      A4D2B2, A4D2B3, B4DT11, D6W5U2, P49848, Q6AI29
      UniProtKB/TrEMBL
      A0A8I5KRU1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_139122.1: Suppressed sequence

      Description
      NM_139122.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    2. NM_139123.1: Suppressed sequence

      Description
      NM_139123.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49848.1 GenPept UniProtKB/Swiss-Prot:P49848

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