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    COMT catechol-O-methyltransferase [ Bos taurus (cattle) ]

    Gene ID: 618278, updated on 5-Mar-2024

    Summary

    Official Symbol
    COMTprovided by VGNC
    Official Full Name
    catechol-O-methyltransferaseprovided by VGNC
    Primary source
    VGNC:VGNC:107259
    See related
    BGD:BT27885; Ensembl:ENSBTAG00000019516
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
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    Genomic context

    Location:
    chromosome: 17
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 17 NC_037344.1 (72900703..72915709)

    Chromosome 17 - NC_037344.1Genomic Context describing neighboring genes Neighboring gene G protein subunit beta 1 like Neighboring gene thioredoxin reductase 2 Neighboring gene ARVCF delta catenin family member Neighboring gene transport and golgi organization 2 homolog Neighboring gene microRNA mir-185 Neighboring gene microRNA mir-1306 Neighboring gene DGCR8 microprocessor complex subunit

    Genomic regions, transcripts, and products

    Genomic Sequence:
    NC_037344.1 Chromosome 17 Reference ARS-UCD2.0 Primary Assembly

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC140449

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables catechol O-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in catecholamine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in developmental process IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in dopamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    PubMed 

    General protein information

    Preferred Names
    catechol O-methyltransferase
    NP_001095787.1
    XP_024833255.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102317.1NP_001095787.1  catechol O-methyltransferase

      See identical proteins and their annotated locations for NP_001095787.1

      Status: PROVISIONAL

      Source sequence(s)
      BC151585
      UniProtKB/Swiss-Prot
      A7MBI7
      Related
      ENSBTAP00000073706.2, ENSBTAT00000083043.2
      Conserved Domains (2) summary
      COG4122
      Location:52241
      YrrM; Predicted O-methyltransferase YrrM [General function prediction only]
      cl17173
      Location:91235
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037344.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      72900703..72915709
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024977487.2XP_024833255.1  catechol O-methyltransferase isoform X1

      Conserved Domains (1) summary
      COG4122
      Location:52241
      YrrM; Predicted O-methyltransferase YrrM [General function prediction only]