RHOA ras homolog family member A [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: RHOAprovided by VGNC
Official Full Name: ras homolog family member Aprovided by VGNC
Primary source: VGNC:VGNC:81924
See related: Ensembl:ENSCAFG00845026916
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: RHO1
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 20

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	20	NC_051824.1 (40180779..40244414)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	20	NC_006602.4 (39743026..39805566)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	20	NC_049241.1 (40231551..40294267)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	20	NC_049280.1 (39548346..39611020)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	20	NC_049761.1 (39951968..40014480)

Chromosome 20 - NC_051824.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Silencing tight junction protein ZO-2 alters epithelial cytoarchitecture.ZO-2 silencing increases RhoA activity through GEF-H1 recruitment to cell borders.ZO-2 silencing activates Cdc42 and triggers mitotic spindle disorientation. ZO-2 silencing increases Rac1 and cofilin activity and lamellipodia formation.
Title: Zonula occludens-2 regulates Rho proteins activity and the development of epithelial cytoarchitecture and barrier function.
RhoA controls the development cell migration fingers through mechanical cues.
Title: Interplay of RhoA and mechanical forces in collective cell migration driven by leader cells.
the RhoA-mediated assembly of adhesome complexes is a fundamental step in the signal transduction process in response to agonist -induced smooth muscle contraction.
Title: The small GTPase RhoA regulates the contraction of smooth muscle tissues by catalyzing the assembly of cytoskeletal signaling complexes at membrane adhesion sites.
the TNF-alpha-induced activation of the ERK/GEF-H1/RhoA pathway in tubular cells is mediated through Src- and TACE-dependent EGFR activation.
Title: The epidermal growth factor receptor mediates tumor necrosis factor-alpha-induced activation of the ERK/GEF-H1/RhoA pathway in tubular epithelium.
Activation of the small GTPase RhoA plays a critical role in the regulation of force generation in intact airway smooth muscle tissues activated by muscarinic stimulation.
Title: The effects of the small GTPase RhoA on the muscarinic contraction of airway smooth muscle result from its role in regulating actin polymerization.
overexpression of either full-length cingulin or its domains does not significantly affect TJ protein levels, gene expression, RhoA activity, cell density, doubling time, and the organization and function of TJ.
Title: Inducible overexpression of cingulin in stably transfected MDCK cells does not affect tight junction organization and gene expression.
Data show that zones of Rac1 and lamellipodia activity and of RhoA and actomyosin contractility are restricted to the periphery of contacting membranes and together drive initiation, expansion, and completion of cell-cell adhesion.
Title: Localized zones of Rho and Rac activities drive initiation and expansion of epithelial cell-cell adhesion.
ROKalpha binds to RhoA in cytosol and translocates to the membrane based on the membrane-targeting ability of active RhoA.
Title: Dynamics of RhoA and ROKalpha translocation in single living cells.
The localized activation of an autocrine HGF/c-Met loop regulates Rho/ROCK activation of p38 MAPK signalling to stimulate both membrane blebbing and pseudopod formation.
Title: Rho/ROCK-dependent pseudopodial protrusion and cellular blebbing are regulated by p38 MAPK in tumour cells exhibiting autocrine c-Met activation.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in stress fiber assembly	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cleavage furrow	IEA Inferred from Electronic Annotation more info	PubMed
located_in dendritic spine	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: transforming protein RhoA

Names: ras homolog gene family, member A; rho1 GTP-binding protein

NP_001003273.2

EC 3.6.5.2

XP_038282302.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003273.3 → NP_001003273.2 transforming protein RhoA

See identical proteins and their annotated locations for NP_001003273.2

Status: VALIDATED

Source sequence(s)

CN004448, DN394819, DR102913

UniProtKB/Swiss-Prot

P24406

UniProtKB/TrEMBL

A0A8C0T4F4, A0A8I3PVV6

Related

ENSCAFP00845037260.1, ENSCAFT00845047489.1

Conserved Domains (1) summary

cd01870
Location:5 → 179

RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051824.1 Reference ROS_Cfam_1.0

Range

40180779..40244414

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038426374.1 → XP_038282302.1 transforming protein RhoA isoform X1

UniProtKB/Swiss-Prot

P24406

UniProtKB/TrEMBL

A0A8C0T4F4, A0A8I3PVV6

Conserved Domains (1) summary

cd01870
Location:5 → 179

RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC