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Rhoa ras homolog family member A [ Mus musculus (house mouse) ]

Gene ID: 11848, updated on 27-Feb-2024

Summary

Official Symbol
Rhoaprovided by MGI
Official Full Name
ras homolog family member Aprovided by MGI
Primary source
MGI:MGI:1096342
See related
Ensembl:ENSMUSG00000007815 AllianceGenome:MGI:1096342
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Arha; Arha1; Arha2
Summary
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in bladder adult (RPKM 88.6), placenta adult (RPKM 81.5) and 28 other tissues See more
Orthologs
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Genomic context

See Rhoa in Genome Data Viewer
Location:
9 F2; 9 59.2 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108183359..108215142)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108306160..108337943)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6805 Neighboring gene aminomethyltransferase Neighboring gene T cell leukemia translocation altered gene Neighboring gene STARR-seq mESC enhancer starr_25204 Neighboring gene STARR-seq mESC enhancer starr_25205 Neighboring gene STARR-positive B cell enhancer ABC_E10585 Neighboring gene glutathione peroxidase 1 Neighboring gene ubiquitin specific peptidase 4 (proto-oncogene) Neighboring gene ribosomal protein S2, pseudogene 11

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
 
enables GDP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables GTPase activity TAS
Traceable Author Statement
more info
PubMed 
enables Rho GDP-dissociation inhibitor binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables myosin binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in GTP metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within Rho protein signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in Roundabout signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in alpha-beta T cell lineage commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within androgen receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in aortic valve formation ISO
Inferred from Sequence Orthology
more info
 
involved_in apical junction assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in apical junction assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in apolipoprotein A-I-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in beta selection IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in bone trabecula morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cell junction assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell-matrix adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to chemokine ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cerebral cortex cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cleavage furrow formation ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoplasmic microtubule organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endothelial cell migration ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within endothelial tube lumen extension ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in establishment of epithelial cell apical/basal polarity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within forebrain radial glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within integrin-mediated signaling pathway TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within kidney development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic cleavage furrow formation ISO
Inferred from Sequence Orthology
more info
 
involved_in mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of motor neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of cell size ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of intracellular steroid hormone receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of motor neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of oxidative phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of reactive oxygen species biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in odontogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in ossification involved in bone maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lipase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within positive regulation of podosome assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of stress fiber assembly IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of vascular associated smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of modification of postsynaptic actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of modification of postsynaptic structure ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of modification of synaptic structure ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of osteoblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of systemic arterial blood pressure by endothelin IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in semaphorin-plexin signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within skeletal muscle tissue development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in stress fiber assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within stress fiber assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in stress-activated protein kinase signaling cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical junction complex ISO
Inferred from Sequence Orthology
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cleavage furrow IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with cleavage furrow ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
transforming protein RhoA
Names
aplysia ras-related homolog A
ras homolog gene family, member A
NP_001300890.1
NP_001300891.1
NP_058082.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313961.1NP_001300890.1  transforming protein RhoA precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC161260, BE990465, CX239638
    Consensus CDS
    CCDS23521.1
    UniProtKB/Swiss-Prot
    O88336, Q9QUI0
    UniProtKB/TrEMBL
    Q3TN61, Q4VAE6
    Related
    ENSMUSP00000141967.2, ENSMUST00000194701.6
    Conserved Domains (1) summary
    cd01870
    Location:5179
    RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC
  2. NM_001313962.1NP_001300891.1  transforming protein RhoA precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC161260, BE990465
    Consensus CDS
    CCDS23521.1
    UniProtKB/Swiss-Prot
    O88336, Q9QUI0
    UniProtKB/TrEMBL
    Q3TN61, Q4VAE6
    Conserved Domains (1) summary
    cd01870
    Location:5179
    RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC
  3. NM_016802.5NP_058082.2  transforming protein RhoA precursor

    See identical proteins and their annotated locations for NP_058082.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC161260, BC068115, BE990465, BP772032, CX217831, CX239124
    Consensus CDS
    CCDS23521.1
    UniProtKB/Swiss-Prot
    O88336, Q9QUI0
    UniProtKB/TrEMBL
    Q3TN61, Q4VAE6
    Related
    ENSMUSP00000007959.9, ENSMUST00000007959.14
    Conserved Domains (1) summary
    cd01870
    Location:5179
    RhoA_like; Ras homology family A (RhoA)-like includes RhoA, RhoB and RhoC

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    108183359..108215142
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)