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    DICER1 dicer 1, ribonuclease III [ Bos taurus (cattle) ]

    Gene ID: 337871, updated on 5-Mar-2024

    Summary

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    Official Symbol
    DICER1provided by VGNC
    Official Full Name
    dicer 1, ribonuclease IIIprovided by VGNC
    Primary source
    VGNC:VGNC:28063
    See related
    BGD:BT29583; Ensembl:ENSBTAG00000012852
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    Dicer
    Orthologs
    human mouse all
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    Genomic context

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    See DICER1 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 21 NC_037348.1 (59956452..59999411, complement)

    Chromosome 21 - NC_037348.1Genomic Context describing neighboring genes Neighboring gene transfer RNA tyrosine (anticodon AUA) Neighboring gene transfer RNA glycine (anticodon GCC) Neighboring gene calmin Neighboring gene uncharacterized LOC112443218

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dicer gene expression during early bovine embryo development. Burrola-Barraza ME, et al. Mol Reprod Dev, 2011 Sep. PMID 21823189
    2. Characterization of gene expression profiles in early bovine pregnancy using a custom cDNA microarray. Ishiwata H, et al. Mol Reprod Dev, 2003 May. PMID 12658628
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables deoxyribonuclease I activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ribonuclease III activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic DNA fragmentation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in pre-miRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in siRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RISC complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    endoribonuclease Dicer
    Names
    Dicer1, Dcr-1 homolog
    dicer 1, ribonuclease type III
    ribonuclease III
    NP_976235.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_203359.1 → NP_976235.1  endoribonuclease Dicer

      See identical proteins and their annotated locations for NP_976235.1

      Status: PROVISIONAL

      Source sequence(s)
      AY386968
      UniProtKB/Swiss-Prot
      Q6TUI4
      UniProtKB/TrEMBL
      A0A3Q1NC30
      Related
      ENSBTAP00000017080.6, ENSBTAT00000017080.7
      Conserved Domains (10) summary
      smart00535
      Location:1296 → 1388
      RIBOc; Ribonuclease III family
      smart00358
      Location:1851 → 1914
      DSRM; Double-stranded RNA binding motif
      COG0571
      Location:1667 → 1919
      Rnc; dsRNA-specific ribonuclease [Transcription]
      COG1111
      Location:37 → 606
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00046
      Location:58 → 209
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00593
      Location:1683 → 1847
      RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
      cd02843
      Location:885 → 1007
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271 → 365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      pfam00271
      Location:445 → 553
      Helicase_C; Helicase conserved C-terminal domain
      pfam03368
      Location:630 → 713
      Dicer_dimer; Dicer dimerization domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037348.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      59956452..59999411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6TUI4.3 GenPept UniProtKB/Swiss-Prot:Q6TUI4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.