Pon3 paraoxonase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pon3provided by RGD
Official Full Name: paraoxonase 3provided by RGD
Primary source: RGD:1302965
See related: Ensembl:ENSRNOG00000009096 AllianceGenome:RGD:1302965
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables 3,4-dihydrocoumarin hydrolase activity and arylesterase activity. Involved in coumarin catabolic process and phenylacetate catabolic process. Located in extracellular space and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; and atherosclerosis. Orthologous to human PON3 (paraoxonase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 1405.3), Lung (RPKM 794.4) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 4q21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (34323546..34350244, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (33356983..33383681, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (30311981..30338679, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study documented, for the first time, the presence of PON3 in rat serum and, notably, found that the upregulation of PON3, rather than PON1, appears to be associated with physical training.
Title: Modulation of paraoxonase 1 and 3 expression after moderate exercise training in the rat.
Purification and characterization of paraoxonase 3 (Pon3) from liver microsomes.
Title: Identification of paraoxonase 3 in rat liver microsomes: purification and biochemical properties.

Submit: New GeneRIF Correction

General gene information

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Markers

AU026023 (e-PCR)
- UniSTS:114688

RH127405 (e-PCR)
- UniSTS:210715

Pon3 (e-PCR), detects polymorphism
- UniSTS:144241

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3,4-dihydrocoumarin hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables acyl-L-homoserine-lactone lactonohydrolase activity	IEA Inferred from Electronic Annotation more info
enables acyl-L-homoserine-lactone lactonohydrolase activity	ISO Inferred from Sequence Orthology more info
enables aryldialkylphosphatase activity	IEA Inferred from Electronic Annotation more info
enables arylesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arylesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables arylesterase activity	IEA Inferred from Electronic Annotation more info
enables arylesterase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in carboxylic acid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in carboxylic acid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in coumarin catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment of localization in cell	IEA Inferred from Electronic Annotation more info
acts_upstream_of establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in lactone catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of superoxide anion generation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of superoxide anion generation	ISO Inferred from Sequence Orthology more info
involved_in phenylacetate catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cellular response to drug	ISO Inferred from Sequence Orthology more info
involved_in renal sodium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of renal sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in response to toxic substance	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serum paraoxonase/lactonase 3

NP_001004086.1

EC 3.1.1.2

EC 3.1.1.81

EC 3.1.8.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.