Pon3 paraoxonase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pon3provided by MGI
Official Full Name: paraoxonase 3provided by MGI
Primary source: MGI:MGI:106686
See related: Ensembl:ENSMUSG00000029759 AllianceGenome:MGI:106686
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2810004E20
Summary: Predicted to enable 3,4-dihydrocoumarin hydrolase activity; arylesterase activity; and protein homodimerization activity. Involved in negative regulation of superoxide anion generation. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; and atherosclerosis. Orthologous to human PON3 (paraoxonase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 16.0), bladder adult (RPKM 15.5) and 22 other tissues See more
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Genomic context

Location:: 6 A1; 6 1.99 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (5216256..5256296, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (5216256..5256285, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Paraoxonase 3 functions as a chaperone to decrease functional expression of the epithelial sodium channel.
Title: Paraoxonase 3 functions as a chaperone to decrease functional expression of the epithelial sodium channel.
study suggests a role for PON3 in the metabolism of lipid and bile acid as well as protection against atherosclerosis, gallstone disease, and obesity
Title: PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis.
PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death.
Title: PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death.
investigation of effect of knockout of Pon3 in embryo: Data suggest that Pon3-/- mice exhibit increased early embryonic and neonatal mortality.
Title: Disruption of paraoxonase 3 impairs proliferation and antioxidant defenses in human A549 cells and causes embryonic lethality in mice.
mouse Pon3 is expressed in a wide range of tissues, and that its expression is temporally controlled
Title: Temporal and tissue-specific patterns of Pon3 expression in mouse: in situ hybridization analysis.
PON3 proteins were present in the vast majority of tissues investigated. mRNA for these proteins was also expressed in most of these tissues suggesting local production and the ability to respond in situ to inflammatory stimuli.
Title: Tissue distribution and expression of paraoxonases and chemokines in mouse: the ubiquitous and joint localisation suggest a systemic and coordinated role.
The directed evolution and characterization of recombinant variants of serum paraoxonase PON3, is described.
Title: Directed evolution of serum paraoxonase PON3 by family shuffling and ancestor/consensus mutagenesis, and its biochemical characterization.
The anti-atherogenic biological activities were studied in vitro using serum or cell cultures, and also in vivo, using PON 1/2/3 knockout or transgenic mice, as well as humans - healthy volunteers and atherosclerotic patients.
Title: Paraoxonases (PON1, PON2, PON3) analyses in vitro and in vivo in relation to cardiovascular diseases.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pon3 (e-PCR), detects polymorphism
- UniSTS:273729

AI786302 (e-PCR)
- UniSTS:165448

Pon3 (e-PCR), detects polymorphism
- UniSTS:144241

PMC197179P2 (e-PCR)
- UniSTS:271848

Pon3 (e-PCR), detects polymorphism
- UniSTS:547560

PMC197179P3 (e-PCR)
- UniSTS:271849

Homology

Homologs of the Pon3 gene: The Pon3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, and C.elegans.
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3,4-dihydrocoumarin hydrolase activity	ISO Inferred from Sequence Orthology more info
enables acyl-L-homoserine-lactone lactonohydrolase activity	IEA Inferred from Electronic Annotation more info
enables aryldialkylphosphatase activity	IEA Inferred from Electronic Annotation more info
enables arylesterase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables arylesterase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in aromatic compound catabolic process	ISO Inferred from Sequence Orthology more info
involved_in carboxylic acid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in coumarin catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of establishment of localization in cell	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of establishment of localization in cell	IPI Inferred from Physical Interaction more info	PubMed
involved_in negative regulation of superoxide anion generation	IDA Inferred from Direct Assay more info	PubMed
involved_in phenylacetate catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of renal sodium ion transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of renal sodium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of renal sodium ion transport	IPI Inferred from Physical Interaction more info	PubMed
involved_in response to toxic substance	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serum paraoxonase/lactonase 3

NP_001350741.1

EC 3.1.1.2

EC 3.1.1.81

EC 3.1.8.1

NP_766594.1

EC 3.1.1.2

EC 3.1.1.81

EC 3.1.8.1

XP_006505152.1

EC 3.1.1.2

EC 3.1.1.81

EC 3.1.8.1

XP_011239364.1

EC 3.1.1.2

EC 3.1.1.81

EC 3.1.8.1

XP_030111286.1

EC 3.1.1.2

EC 3.1.1.81

EC 3.1.8.1

XP_036022087.1

EC 3.1.1.2

EC 3.1.1.81

EC 3.1.8.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001363812.2 → NP_001350741.1 serum paraoxonase/lactonase 3 isoform 2

Status: VALIDATED

Source sequence(s)

AC164289

Conserved Domains (1) summary

pfam01731
Location:94 → 179

Arylesterase
NM_001411739.1 → NP_001398668.1 serum paraoxonase/lactonase 3 isoform 2

Status: VALIDATED

Source sequence(s)

AC164289
NM_001411740.1 → NP_001398669.1 serum paraoxonase/lactonase 3 isoform 2

Status: VALIDATED

Source sequence(s)

AC164289
NM_001411741.1 → NP_001398670.1 serum paraoxonase/lactonase 3 isoform 2

Status: VALIDATED

Source sequence(s)

AC164289
NM_001411742.1 → NP_001398671.1 serum paraoxonase/lactonase 3 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC164289
NM_001411743.1 → NP_001398672.1 serum paraoxonase/lactonase 3 isoform 4

Status: VALIDATED

Source sequence(s)

AC164289
NM_001411744.1 → NP_001398673.1 serum paraoxonase/lactonase 3 isoform 5

Status: VALIDATED

Source sequence(s)

AC164289
NM_001411745.1 → NP_001398674.1 serum paraoxonase/lactonase 3 isoform 5

Status: VALIDATED

Source sequence(s)

AC164289
NM_173006.3 → NP_766594.1 serum paraoxonase/lactonase 3 isoform 1 precursor

See identical proteins and their annotated locations for NP_766594.1

Status: VALIDATED

Source sequence(s)

AC164289

Consensus CDS

CCDS19899.1

UniProtKB/Swiss-Prot

Q62087, Q8C2I7

Related

ENSMUSP00000031773.3, ENSMUST00000031773.9

Conserved Domains (1) summary

pfam01731
Location:167 → 252

Arylesterase; Arylesterase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

5216256..5256296 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505089.5 → XP_006505152.1 serum paraoxonase/lactonase 3 isoform X1

Conserved Domains (1) summary

pfam01731
Location:94 → 179

Arylesterase
XM_011241062.4 → XP_011239364.1 serum paraoxonase/lactonase 3 isoform X1

Conserved Domains (1) summary

pfam01731
Location:94 → 179

Arylesterase
XM_036166194.1 → XP_036022087.1 serum paraoxonase/lactonase 3 isoform X1

Conserved Domains (1) summary

pfam01731
Location:94 → 179

Arylesterase
XM_030255426.2 → XP_030111286.1 serum paraoxonase/lactonase 3 isoform X1

Conserved Domains (1) summary

pfam01731
Location:94 → 179

Arylesterase