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PON3 paraoxonase 3 [ Homo sapiens (human) ]

Gene ID: 5446, updated on 21-Dec-2019

Summary

Official Symbol
PON3provided by HGNC
Official Full Name
paraoxonase 3provided by HGNC
Primary source
HGNC:HGNC:9206
See related
Ensembl:ENSG00000105852 MIM:602720
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008]
Expression
Biased expression in liver (RPKM 130.3) and ovary (RPKM 7.4) See more
Orthologs

Genomic context

See PON3 in Genome Data Viewer
Location:
7q21.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (95359872..95396375, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (94989181..95025702, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene paraoxonase 1 Neighboring gene HERV-FRD provirus ancestral Env polyprotein pseudogene Neighboring gene uncharacterized LOC107986822 Neighboring gene paraoxonase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
capsid gag The interaction of HIV-1 CA with human cellular paraoxonase 3 protein (PON3) is identified by yeast two-hybrid screen PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: PON1

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3,4-dihydrocoumarin hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
acyl-L-homoserine-lactone lactonohydrolase activity IEA
Inferred from Electronic Annotation
more info
 
aryldialkylphosphatase activity IEA
Inferred from Electronic Annotation
more info
 
arylesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
arylesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
arylesterase activity NAS
Non-traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
aromatic compound catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
carboxylic acid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
coumarin catabolic process IEA
Inferred from Electronic Annotation
more info
 
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
lipoxygenase pathway TAS
Traceable Author Statement
more info
 
negative regulation of superoxide anion generation IEA
Inferred from Electronic Annotation
more info
 
phenylacetate catabolic process IEA
Inferred from Electronic Annotation
more info
 
response to toxic substance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serum paraoxonase/lactonase 3
Names
arylesterase 3
paraoxanase-3
NP_000931.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008726.1 RefSeqGene

    Range
    5001..41504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000940.3NP_000931.1  serum paraoxonase/lactonase 3

    See identical proteins and their annotated locations for NP_000931.1

    Status: REVIEWED

    Source sequence(s)
    AA860930, AV655538, BC020908, BC070374, CD014095
    Consensus CDS
    CCDS5639.1
    UniProtKB/Swiss-Prot
    Q15166
    Related
    ENSP00000265627.5, ENST00000265627.10
    Conserved Domains (1) summary
    pfam01731
    Location:167252
    Arylesterase; Arylesterase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    95359872..95396375 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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