Lancl1 LanC like glutathione S-transferase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lancl1provided by RGD
Official Full Name: LanC like glutathione S-transferase 1provided by RGD
Primary source: RGD:69416
See related: Ensembl:ENSRNOG00000013557 AllianceGenome:RGD:69416
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: p40; GPR69A
Summary: Predicted to enable several functions, including SH3 domain binding activity; glutathione binding activity; and glutathione transferase activity. Predicted to be involved in regulation of neuron apoptotic process and regulation of oxidative stress-induced neuron death. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Orthologous to human LANCL1 (LanC like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 777.3), Brain (RPKM 399.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q32

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (75968284..75998397, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (68515052..68548646, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (74018192..74048098, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lanthionine synthetase C-like protein 1 interacts with and inhibits cystathionine beta-synthase: a target for neuronal antioxidant defense.
Title: Lanthionine synthetase C-like protein 1 interacts with and inhibits cystathionine β-synthase: a target for neuronal antioxidant defense.
expression of LanCL1 mutants defective in Eps8 interaction inhibits nerve growth factor (NGF)-induced neurite outgrowth
Title: Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione.
LanC-like protein 1 expression in rat testes was initiated already in pachytene spermatocytes in stage IX, but otherwise similar to mouse.
Title: Germ cell differentiation-dependent and stage-specific expression of LANCL1 in rodent testis.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables glutathione binding	IEA Inferred from Electronic Annotation more info
enables glutathione binding	ISO Inferred from Sequence Orthology more info
enables glutathione binding	ISS Inferred from Sequence or Structural Similarity more info
enables glutathione transferase activity	IEA Inferred from Electronic Annotation more info
enables glutathione transferase activity	ISO Inferred from Sequence Orthology more info
enables glutathione transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables low-density lipoprotein particle receptor binding	IEA Inferred from Electronic Annotation more info
enables low-density lipoprotein particle receptor binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
NOT involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
NOT involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cellular detoxification	IEA Inferred from Electronic Annotation more info
involved_in cellular detoxification	ISO Inferred from Sequence Orthology more info
involved_in cellular detoxification	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptide modification	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
NOT located_in plasma membrane	ISO Inferred from Sequence Orthology more info
NOT located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: glutathione S-transferase LANCL1

Names: 40 kDa erythrocyte membrane protein; LanC lantibiotic synthetase component C-like 1; LanC like 1; LanC-like 1(bacterial); lanC (bacterial lantibiotic synthetase component C)-like 1; lanC-like protein 1

NP_446175.1

EC 2.5.1.18

XP_038938832.1

EC 2.5.1.18

XP_038938833.1

EC 2.5.1.18

XP_063122604.1

EC 2.5.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053723.1 → NP_446175.1 glutathione S-transferase LANCL1

See identical proteins and their annotated locations for NP_446175.1

Status: PROVISIONAL

Source sequence(s)

AJ131111

UniProtKB/Swiss-Prot

Q9ER29, Q9QX69

UniProtKB/TrEMBL

A0A8I6A0Q6, A6KFE1

Related

ENSRNOP00000085697.1, ENSRNOT00000095161.1

Conserved Domains (2) summary

cd04794
Location:62 → 395

euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein

cl04955
Location:1 → 94

LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

75968284..75998397 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063266534.1 → XP_063122604.1 glutathione S-transferase LANCL1 isoform X1

UniProtKB/Swiss-Prot

Q9ER29, Q9QX69

UniProtKB/TrEMBL

A6KFE1
XM_039082904.2 → XP_038938832.1 glutathione S-transferase LANCL1 isoform X1

UniProtKB/Swiss-Prot

Q9ER29, Q9QX69

UniProtKB/TrEMBL

A0A8I6A0Q6, A6KFE1

Conserved Domains (2) summary

cd04794
Location:62 → 395

euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein

cl04955
Location:1 → 94

LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins
XM_039082905.2 → XP_038938833.1 glutathione S-transferase LANCL1 isoform X1

UniProtKB/Swiss-Prot

Q9ER29, Q9QX69

UniProtKB/TrEMBL

A0A8I6A0Q6, A6KFE1

Conserved Domains (2) summary

cd04794
Location:62 → 395

euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein

cl04955
Location:1 → 94

LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins