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LANCL1 LanC like 1 [ Homo sapiens (human) ]

Gene ID: 10314, updated on 12-Aug-2018

Summary

Official Symbol
LANCL1provided by HGNC
Official Full Name
LanC like 1provided by HGNC
Primary source
HGNC:HGNC:6508
See related
Ensembl:ENSG00000115365 MIM:604155; Vega:OTTHUMG00000132991
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p40; GPR69A
Summary
This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]
Expression
Ubiquitous expression in brain (RPKM 58.9), testis (RPKM 27.8) and 24 other tissues See more
Orthologs

Genomic context

See LANCL1 in Genome Data Viewer
Location:
2q34
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (210431249..210477618, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (211295973..211342347, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene acyl-CoA dehydrogenase long chain Neighboring gene LANCL1 antisense RNA 1 Neighboring gene myosin light chain 1 Neighboring gene carbamoyl-phosphate synthase 1 Neighboring gene CPS1 intron CAGE-defined high expression enhancer 1 Neighboring gene CPS1 intron CAGE-defined high expression enhancer 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
SH3 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
glutathione binding IDA
Inferred from Direct Assay
more info
PubMed 
low-density lipoprotein particle receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
NOT G-protein coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
NOT integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
lanC-like protein 1
Names
40 kDa erythrocyte membrane protein
G protein-coupled receptor 69A
LanC (bacterial lantibiotic synthetase component C)-like 1
LanC (bacterial lantibiotic synthetase component)
LanC lantibiotic synthetase component C-like 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136574.1NP_001130046.1  lanC-like protein 1

    See identical proteins and their annotated locations for NP_001130046.1

    Status: REVIEWED

    Description
    Transcript Variant: Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC007970, BC028685, BX473106
    Consensus CDS
    CCDS2392.1
    UniProtKB/Swiss-Prot
    O43813
    UniProtKB/TrEMBL
    Q53TN2
    Related
    ENSP00000233714.4, OTTHUMP00000206536, ENST00000233714.8, OTTHUMT00000336816
    Conserved Domains (2) summary
    cd04794
    Location:62395
    euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein
    cl04955
    Location:189
    LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins
  2. NM_001136575.1NP_001130047.1  lanC-like protein 1

    See identical proteins and their annotated locations for NP_001130047.1

    Status: REVIEWED

    Description
    Transcript Variant: Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC007970, AK312381, BX473106, DC321883
    Consensus CDS
    CCDS2392.1
    UniProtKB/Swiss-Prot
    O43813
    UniProtKB/TrEMBL
    B2R602, Q53TN2
    Related
    ENSP00000397646.2, OTTHUMP00000206535, ENST00000431941.6, OTTHUMT00000336815
    Conserved Domains (2) summary
    cd04794
    Location:62395
    euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein
    cl04955
    Location:189
    LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins
  3. NM_006055.2NP_006046.1  lanC-like protein 1

    See identical proteins and their annotated locations for NP_006046.1

    Status: REVIEWED

    Description
    Transcript Variant: Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC007970, BX473106, DC324843, Y11395
    Consensus CDS
    CCDS2392.1
    UniProtKB/Swiss-Prot
    O43813
    UniProtKB/TrEMBL
    Q53TN2
    Related
    ENSP00000393597.2, OTTHUMP00000163940, ENST00000450366.6, OTTHUMT00000256565
    Conserved Domains (2) summary
    cd04794
    Location:62395
    euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein
    cl04955
    Location:189
    LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    210431249..210477618 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246243.2XP_005246300.1  lanC-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005246300.1

    UniProtKB/TrEMBL
    A0A024R3Z5
    Conserved Domains (2) summary
    cd04794
    Location:74407
    euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein
    cl04955
    Location:13101
    LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins
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