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Lancl1 LanC (bacterial lantibiotic synthetase component C)-like 1 [ Mus musculus (house mouse) ]

Gene ID: 14768, updated on 5-Feb-2023

Summary

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Official Symbol
Lancl1provided by MGI
Official Full Name
LanC (bacterial lantibiotic synthetase component C)-like 1provided by MGI
Primary source
MGI:MGI:1336997
See related
Ensembl:ENSMUSG00000026000 AllianceGenome:MGI:1336997
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p40; Gpr69; Gpr69a
Summary
Enables glutathione transferase activity. Involved in regulation of neuron apoptotic process and regulation of oxidative stress-induced neuron death. Predicted to be located in cytoplasm and membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human LANCL1 (LanC like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 84.4), cortex adult (RPKM 23.2) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Lancl1 in Genome Data Viewer
Location:
1; 1 C3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (67039676..67078049, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (67000517..67038891, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31, pseudogene 14 Neighboring gene histidyl-tRNA synthetase pseudogene Neighboring gene uncharacterized LOC115487097 Neighboring gene carbamoyl-phosphate synthetase 1 Neighboring gene predicted gene, 26342

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LanCL1 promotes motor neuron survival and extends the lifespan of amyotrophic lateral sclerosis mice. Tan H, et al. Cell Death Differ, 2020 Apr. PMID 31570855, Free PMC Article
  2. Molecular characterization and tissue-specific expression of a murine putative G-protein-coupled receptor. Mayer H, et al. Biochim Biophys Acta, 1998 Jul 30. PMID 9714732
  3. Animal models of male subfertility targeted on LanCL1-regulated spermatogenic redox homeostasis. Huang C, et al. Lab Anim (NY), 2022 May. PMID 35469022
  4. Germ cell differentiation-dependent and stage-specific expression of LANCL1 in rodent testis. Nielsen JE, et al. Eur J Histochem, 2003. PMID 14514412
  5. Organization and chromosomal localization of the human and mouse genes coding for LanC-like protein 1 (LANCL1). Mayer H, et al. Cytogenet Cell Genet, 2001. PMID 11474189

See all (35) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LanCL1 promotes motor neuron survival and extends the lifespan of amyotrophic lateral sclerosis mice.
    Title: LanCL1 promotes motor neuron survival and extends the lifespan of amyotrophic lateral sclerosis mice.
  2. Very similar concentrations of lanthionine ketimine (0.5-2.5 nmol/g tissue) were found in LanCL1 knock-out, LanCL1/LanCL2/LanCL3 triple-knock-out and wild type (WT) mouse brains, suggesting that LanCL proteins are not involved in lanthionine biosynthesis.
    Title: LanCL proteins are not Involved in Lanthionine Synthesis in Mammals.
  3. Loss of LanCL1 causes progressive oxidative damage and neuronal death. LanCL1 transgene protects neurons from oxidative stress.
    Title: Developmental and activity-dependent expression of LanCL1 confers antioxidant activity required for neuronal survival.
  4. Lanthionine synthetase C-like protein 1 interacts with and inhibits cystathionine beta-synthase: a target for neuronal antioxidant defense.
    Title: Lanthionine synthetase C-like protein 1 interacts with and inhibits cystathionine β-synthase: a target for neuronal antioxidant defense.
  5. LanC-like protein 1 expression in rat testes was initiated already in pachytene spermatocytes in stage IX, but otherwise similar to mouse.
    Title: Germ cell differentiation-dependent and stage-specific expression of LANCL1 in rodent testis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables glutathione binding ISO
Inferred from Sequence Orthology
more info
  
enables glutathione transferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of oxidative stress-induced neuron death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
glutathione S-transferase LANCL1
Names
40 kDa erythrocyte membrane protein
G protein-coupled receptor 69
G protein-coupled receptor 69A
LanC-like protein 1
NP_001177913.1
NP_001177914.1
NP_067270.1
XP_011236737.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190984.1 → NP_001177913.1  glutathione S-transferase LANCL1

    See identical proteins and their annotated locations for NP_001177913.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC133187, BC058560
    Consensus CDS
    CCDS15025.1
    UniProtKB/Swiss-Prot
    O89112
    Related
    ENSMUSP00000113080.2, ENSMUST00000119559.8
    Conserved Domains (2) summary
    cd04794
    Location:62 → 395
    euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein
    cl04955
    Location:1 → 89
    LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins

  2. NM_001190985.1 → NP_001177914.1  glutathione S-transferase LANCL1

    See identical proteins and their annotated locations for NP_001177914.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC133187
    Consensus CDS
    CCDS15025.1
    UniProtKB/Swiss-Prot
    O89112
    Related
    ENSMUSP00000109612.4, ENSMUST00000113979.10
    Conserved Domains (2) summary
    cd04794
    Location:62 → 395
    euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein
    cl04955
    Location:1 → 89
    LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins

  3. NM_021295.3 → NP_067270.1  glutathione S-transferase LANCL1

    See identical proteins and their annotated locations for NP_067270.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC133187, Y11550
    Consensus CDS
    CCDS15025.1
    UniProtKB/Swiss-Prot
    O89112
    Related
    ENSMUSP00000027149.6, ENSMUST00000027149.12
    Conserved Domains (2) summary
    cd04794
    Location:62 → 395
    euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein
    cl04955
    Location:1 → 89
    LanC_like; Cyclases involved in the biosynthesis of lantibiotics, and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    67039676..67078049 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238435.4 → XP_011236737.1  glutathione S-transferase LANCL1 isoform X1

    Conserved Domains (1) summary
    cd04794
    Location:16 → 349
    euk_LANCL; Eukaryotic Lanthionine synthetase C-like protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O89112.1 GenPept UniProtKB/Swiss-Prot:O89112

Gene LinkOut

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