Gpr18 G protein-coupled receptor 18 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpr18provided by RGD
Official Full Name: G protein-coupled receptor 18provided by RGD
Primary source: RGD:1304889
See related: Ensembl:ENSRNOG00000012628 AllianceGenome:RGD:1304889
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in positive regulation of Rho protein signal transduction and positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway. Predicted to act upstream of or within T cell differentiation; negative regulation of leukocyte chemotaxis; and negative regulation of tumor necrosis factor production. Predicted to be located in cytoplasmic vesicle membrane. Predicted to be integral component of plasma membrane. Orthologous to human GPR18 (G protein-coupled receptor 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 130.0), Thymus (RPKM 76.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15q25

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (105404062..105407812, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (98997427..99001177, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (108323157..108326907, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GPR18-NAGly system in periaqueductal gray and chronic neuropathic pain.
Title: GPR18-NAGly system in periaqueductal gray and chronic neuropathic pain.
A Novel Alternative in the Treatment of Detrusor Overactivity? In Vivo Activity of O-1602, the Newly Synthesized Agonist of GPR55 and GPR18 Cannabinoid Receptors.
Title: A Novel Alternative in the Treatment of Detrusor Overactivity? In Vivo Activity of O-1602, the Newly Synthesized Agonist of GPR55 and GPR18 Cannabinoid Receptors.
The role of a novel cannabinoid receptor GPR18, espressed in the rostral ventrolateral medulla, in central blood pressure control.
Title: The novel endocannabinoid receptor GPR18 is expressed in the rostral ventrolateral medulla and exerts tonic restraining influence on blood pressure.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within CD8-positive, alpha-beta intraepithelial T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within CD8-positive, gamma-delta intraepithelial T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of leukocyte chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: N-arachidonyl glycine receptor

Names: NAGly receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001079710.1 → NP_001073178.1 N-arachidonyl glycine receptor

See identical proteins and their annotated locations for NP_001073178.1

Status: PROVISIONAL

Source sequence(s)

BC128782

UniProtKB/Swiss-Prot

A1A5S3

UniProtKB/TrEMBL

A6HUK8

Related

ENSRNOP00000016848.2, ENSRNOT00000016848.5

Conserved Domains (2) summary

pfam00001
Location:40 → 286

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl22924
Location:27 → 289

7TM_GPCR_Srd; Serpentine type 7TM GPCR chemoreceptor Srd