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Gpr18 G protein-coupled receptor 18 [ Mus musculus (house mouse) ]

Gene ID: 110168, updated on 13-Dec-2022

Summary

Official Symbol
Gpr18provided by MGI
Official Full Name
G protein-coupled receptor 18provided by MGI
Primary source
MGI:MGI:107859
See related
Ensembl:ENSMUSG00000050350 AllianceGenome:MGI:107859
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable G protein-coupled receptor activity. Acts upstream of or within T cell differentiation; negative regulation of leukocyte chemotaxis; and negative regulation of tumor necrosis factor production. Predicted to be located in cytoplasmic vesicle and plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Orthologous to human GPR18 (G protein-coupled receptor 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 55.1), mammary gland adult (RPKM 20.1) and 4 other tissues See more
Orthologs
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Genomic context

See Gpr18 in Genome Data Viewer
Location:
14 E5; 14 65.86 cM
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (122148846..122153300, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (121911434..121915888, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9395 Neighboring gene RIKEN cDNA 1810041H14 gene Neighboring gene ubiquitin associated domain containing 2 Neighboring gene predicted gene, 46485 Neighboring gene G protein-coupled receptor 183 Neighboring gene predicted gene, 52103 Neighboring gene translocase of inner mitochondrial membrane 8A2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within CD8-positive, alpha-beta intraepithelial T cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within CD8-positive, alpha-beta intraepithelial T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within CD8-positive, gamma-delta intraepithelial T cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within CD8-positive, gamma-delta intraepithelial T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of leukocyte chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
N-arachidonyl glycine receptor
Names
NAGly receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182806.2NP_877958.1  N-arachidonyl glycine receptor

    See identical proteins and their annotated locations for NP_877958.1

    Status: VALIDATED

    Source sequence(s)
    AC154180
    Consensus CDS
    CCDS27342.1
    UniProtKB/Swiss-Prot
    Q3T9N3, Q8K1Z6
    Related
    ENSMUSP00000061410.8, ENSMUST00000055475.9
    Conserved Domains (1) summary
    pfam00001
    Location:40286
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    122148846..122153300 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)