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GPR18 G protein-coupled receptor 18 [ Homo sapiens (human) ]

Gene ID: 2841, updated on 22-Sep-2022

Summary

Official Symbol
GPR18provided by HGNC
Official Full Name
G protein-coupled receptor 18provided by HGNC
Primary source
HGNC:HGNC:4472
See related
Ensembl:ENSG00000125245 MIM:602042; AllianceGenome:HGNC:4472
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in positive regulation of Rho protein signal transduction and positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway. Predicted to act upstream of or within T cell differentiation; negative regulation of leukocyte chemotaxis; and negative regulation of tumor necrosis factor production. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lymph node (RPKM 11.0), testis (RPKM 4.7) and 4 other tissues See more
Orthologs
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Genomic context

See GPR18 in Genome Data Viewer
Location:
13q32.3
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (99254739..99258379, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (98464982..98468623, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (99906993..99910633, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 9 Neighboring gene UBA domain containing 2 Neighboring gene H2A.Z histone pseudogene 3 Neighboring gene uncharacterized LOC124903198 Neighboring gene G protein-coupled receptor 183

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
N-arachidonyl glycine receptor
Names
NAGly receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098200.2NP_001091670.1  N-arachidonyl glycine receptor

    See identical proteins and their annotated locations for NP_001091670.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA825595, BC008569
    Consensus CDS
    CCDS9491.1
    UniProtKB/Swiss-Prot
    Q14330, Q9H2L2
    UniProtKB/TrEMBL
    H9NIM1
    Related
    ENSP00000380610.2, ENST00000397470.5
    Conserved Domains (1) summary
    cd15166
    Location:23297
    7tmA_NAGly_R_GPR18; N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_005292.4NP_005283.1  N-arachidonyl glycine receptor

    See identical proteins and their annotated locations for NP_005283.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL160155, BC050646, BI770379
    Consensus CDS
    CCDS9491.1
    UniProtKB/Swiss-Prot
    Q14330, Q9H2L2
    UniProtKB/TrEMBL
    H9NIM1
    Related
    ENSP00000380613.2, ENST00000397473.7
    Conserved Domains (1) summary
    cd15166
    Location:23297
    7tmA_NAGly_R_GPR18; N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    99254739..99258379 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    98464982..98468623 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)