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GPR18 G protein-coupled receptor 18 [ Homo sapiens (human) ]

Gene ID: 2841, updated on 8-Jul-2021

Summary

Official Symbol
GPR18provided by HGNC
Official Full Name
G protein-coupled receptor 18provided by HGNC
Primary source
HGNC:HGNC:4472
See related
Ensembl:ENSG00000125245 MIM:602042
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in lymph node (RPKM 11.0), testis (RPKM 4.7) and 4 other tissues See more
Orthologs
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Genomic context

See GPR18 in Genome Data Viewer
Location:
13q32.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (99254713..99262498, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (99906993..99910633, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene UBA domain containing 2 Neighboring gene RN7SK pseudogene 9 Neighboring gene H2A.Z histone pseudogene 3 Neighboring gene G protein-coupled receptor 183 Neighboring gene FKSG29

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
N-arachidonyl glycine receptor
Names
NAGly receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098200.2NP_001091670.1  N-arachidonyl glycine receptor

    See identical proteins and their annotated locations for NP_001091670.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA825595, BC008569
    Consensus CDS
    CCDS9491.1
    UniProtKB/Swiss-Prot
    Q14330
    UniProtKB/TrEMBL
    H9NIM1
    Related
    ENSP00000380610.2, ENST00000397470.5
    Conserved Domains (1) summary
    cd15166
    Location:23297
    7tmA_NAGly_R_GPR18; N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_005292.4NP_005283.1  N-arachidonyl glycine receptor

    See identical proteins and their annotated locations for NP_005283.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL160155, BC050646, BI770379
    Consensus CDS
    CCDS9491.1
    UniProtKB/Swiss-Prot
    Q14330
    UniProtKB/TrEMBL
    H9NIM1
    Related
    ENSP00000380613.2, ENST00000397473.7
    Conserved Domains (1) summary
    cd15166
    Location:23297
    7tmA_NAGly_R_GPR18; N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    99254713..99262498 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719946.3XP_006720009.1  N-arachidonyl glycine receptor isoform X1

    See identical proteins and their annotated locations for XP_006720009.1

    UniProtKB/Swiss-Prot
    Q14330
    UniProtKB/TrEMBL
    H9NIM1
    Related
    ENSP00000343428.3, ENST00000340807.3
    Conserved Domains (1) summary
    cd15166
    Location:23297
    7tmA_NAGly_R_GPR18; N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_024449339.1XP_024305107.1  N-arachidonyl glycine receptor isoform X1

    Related
    ENSP00000401611.2, ENST00000416594.2
    Conserved Domains (1) summary
    cd15166
    Location:23297
    7tmA_NAGly_R_GPR18; N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors
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