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GPR18 G protein-coupled receptor 18 [ Homo sapiens (human) ]

Gene ID: 2841, updated on 10-Dec-2019

Summary

Official Symbol
GPR18provided by HGNC
Official Full Name
G protein-coupled receptor 18provided by HGNC
Primary source
HGNC:HGNC:4472
See related
Ensembl:ENSG00000125245 MIM:602042
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in lymph node (RPKM 11.0), testis (RPKM 4.7) and 4 other tissues See more
Orthologs

Genomic context

See GPR18 in Genome Data Viewer
Location:
13q32.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (99254713..99262498, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (99906967..99910682, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene UBA domain containing 2 Neighboring gene RN7SK pseudogene 9 Neighboring gene H2A.Z histone pseudogene 3 Neighboring gene G protein-coupled receptor 183 Neighboring gene FKSG29

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

Pathways from BioSystems

  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • GPCRs, Other, organism-specific biosystem (from WikiPathways)
    GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
N-arachidonyl glycine receptor
Names
NAGly receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098200.1NP_001091670.1  N-arachidonyl glycine receptor

    See identical proteins and their annotated locations for NP_001091670.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA825595, BC008569, BI770379
    Consensus CDS
    CCDS9491.1
    UniProtKB/Swiss-Prot
    Q14330
    UniProtKB/TrEMBL
    H9NIM1
    Related
    ENSP00000380610.2, ENST00000397470.4
    Conserved Domains (1) summary
    cd15166
    Location:23297
    7tmA_NAGly_R_GPR18; N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_005292.3NP_005283.1  N-arachidonyl glycine receptor

    See identical proteins and their annotated locations for NP_005283.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA825595, AL160155, BC050646, BI770379
    Consensus CDS
    CCDS9491.1
    UniProtKB/Swiss-Prot
    Q14330
    UniProtKB/TrEMBL
    H9NIM1
    Related
    ENSP00000380613.2, ENST00000397473.6
    Conserved Domains (1) summary
    cd15166
    Location:23297
    7tmA_NAGly_R_GPR18; N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    99254713..99262498 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719946.3XP_006720009.1  N-arachidonyl glycine receptor isoform X1

    See identical proteins and their annotated locations for XP_006720009.1

    UniProtKB/Swiss-Prot
    Q14330
    UniProtKB/TrEMBL
    H9NIM1
    Related
    ENSP00000343428.3, ENST00000340807.3
    Conserved Domains (1) summary
    cd15166
    Location:23297
    7tmA_NAGly_R_GPR18; N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_024449339.1XP_024305107.1  N-arachidonyl glycine receptor isoform X1

    Conserved Domains (1) summary
    cd15166
    Location:23297
    7tmA_NAGly_R_GPR18; N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors
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