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    TLR8 toll like receptor 8 [ Sus scrofa (pig) ]

    Gene ID: 397384, updated on 5-Mar-2024

    Summary

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    Official Symbol
    TLR8provided by VGNC
    Official Full Name
    toll like receptor 8provided by VGNC
    Primary source
    VGNC:VGNC:94027
    See related
    Ensembl:ENSSSCG00000012118
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    TLR7
    Expression
    Biased expression in spleen (RPKM 29.8), lung (RPKM 8.2) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: X
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) X NC_010461.5 (9551284..9616762)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) X NC_010461.4 (10451110..10512940)

    Chromosome X - NC_010461.5Genomic Context describing neighboring genes Neighboring gene FERM and PDZ domain containing 4 Neighboring gene histone transcription regulator 3 homolog Neighboring gene phosphoribosyl pyrophosphate synthetase 2 Neighboring gene uncharacterized LOC100511794 Neighboring gene toll like receptor 7 Neighboring gene thymosin beta 4 X-linked

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Identification of imidazoquinoline derivative (IQD) interacting sites of porcine TLR8 and the underlying species specificity. Ao D, et al. Mol Immunol, 2021 Aug. PMID 34082258
    2. Molecular identification and functional expression of porcine Toll-like receptor (TLR) 3 and TLR7. Sang Y, et al. Vet Immunol Immunopathol, 2008 Sep 15. PMID 18533275
    3. Porcine TLR8 and TLR7 are both activated by a selective TLR7 ligand, imiquimod. Zhu J, et al. Mol Immunol, 2008 Jun. PMID 18439678
    4. Toll-like receptor 4 and cytokine expression involved in functional immune response in an originally established porcine intestinal epitheliocyte cell line. Moue M, et al. Biochim Biophys Acta, 2008 Feb. PMID 18082146
    5. Characterization of equine and other vertebrate TLR3, TLR7, and TLR8 genes. Astakhova NM, et al. Immunogenetics, 2009 Jul. PMID 19568743

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of imidazoquinoline derivative (IQD) interacting sites of porcine TLR8 and the underlying species specificity.
      Title: Identification of imidazoquinoline derivative (IQD) interacting sites of porcine TLR8 and the underlying species specificity.
    2. Porcine TLR7 and TLR8 genes from pig lymph node tissue, were cloned and characterized.
      Title: Porcine TLR8 and TLR7 are both activated by a selective TLR7 ligand, imiquimod.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables pattern recognition receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of interleukin-6 production IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    toll-like receptor 8
    Names
    Toll-like receptor 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214187.1 → NP_999352.1  toll-like receptor 8 precursor

      See identical proteins and their annotated locations for NP_999352.1

      Status: PROVISIONAL

      Source sequence(s)
      AB092975
      UniProtKB/TrEMBL
      A0A8D0XNY5, A0A8D1DWE5, A0A8D1T7X2, A0A8D1VTE0, A5JVA2, B6EUP3, Q865R7
      Related
      ENSSSCP00000030352.1, ENSSSCT00000033339.4
      Conserved Domains (6) summary
      smart00082
      Location:761 → 806
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:869 → 1005
      TIR; Toll - interleukin 1 - resistance
      cd00116
      Location:569 → 762
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:500 → 521
      LRR_RI; leucine-rich repeat [structural motif]
      pfam12799
      Location:213 → 246
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:212 → 289
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010461.5 Reference Sscrofa11.1 Primary Assembly

      Range
      9551284..9616762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021079509.1 → XP_020935168.1  toll-like receptor 8 isoform X3

      UniProtKB/TrEMBL
      A0A4X1TK68, A0A8D0XNY5, A0A8D1DWE5, A0A8D1T7X2, A0A8D1VTE0, A5JVA2, B3XXC2, B6EUP3, F6Q790
      Conserved Domains (6) summary
      smart00082
      Location:761 → 806
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:869 → 1005
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:500 → 521
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:62 → 94
      LRR_8; Leucine rich repeat
      cl26018
      Location:630 → 765
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:154 → 690
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

    2. XM_021079507.1 → XP_020935166.1  toll-like receptor 8 isoform X3

      UniProtKB/TrEMBL
      A0A4X1TK68, A0A8D0XNY5, A0A8D1DWE5, A0A8D1T7X2, A0A8D1VTE0, A5JVA2, B3XXC2, B6EUP3, F6Q790
      Related
      ENSSSCP00000012899.4, ENSSSCT00000013255.5
      Conserved Domains (6) summary
      smart00082
      Location:761 → 806
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:869 → 1005
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:500 → 521
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:62 → 94
      LRR_8; Leucine rich repeat
      cl26018
      Location:630 → 765
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:154 → 690
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

    3. XM_021079508.1 → XP_020935167.1  toll-like receptor 8 isoform X3

      UniProtKB/TrEMBL
      A0A4X1TK68, A0A8D0XNY5, A0A8D1DWE5, A0A8D1T7X2, A0A8D1VTE0, A5JVA2, B3XXC2, B6EUP3, F6Q790
      Conserved Domains (6) summary
      smart00082
      Location:761 → 806
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:869 → 1005
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:500 → 521
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:62 → 94
      LRR_8; Leucine rich repeat
      cl26018
      Location:630 → 765
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:154 → 690
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

    4. XM_021079505.1 → XP_020935164.1  toll-like receptor 8 isoform X1

      UniProtKB/TrEMBL
      A0A8D0XNY5, A0A8D1DWE5, A0A8D1T7X2, A0A8D1VTE0, A5JVA2, B6EUP3
      Conserved Domains (6) summary
      TIGR00864
      Location:810 → 893
      PCC; polycystin cation channel protein
      smart00255
      Location:948 → 1084
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:579 → 600
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:141 → 173
      LRR_8; Leucine rich repeat
      cl26018
      Location:709 → 844
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:233 → 769
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

    5. XM_021079506.1 → XP_020935165.1  toll-like receptor 8 isoform X2

      UniProtKB/TrEMBL
      A0A8D0XNY5, A0A8D1DWE5, A0A8D1T7X2, A0A8D1VTE0, A5JVA2, B6EUP3
      Conserved Domains (5) summary
      smart00082
      Location:839 → 884
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:947 → 1083
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:578 → 599
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:755 → 815
      LRR_8; Leucine rich repeat
      cl26793
      Location:232 → 768
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

    6. XM_013985895.2 → XP_013841349.1  toll-like receptor 8 isoform X3

      UniProtKB/TrEMBL
      A0A4X1TK68, A0A8D0XNY5, A0A8D1DWE5, A0A8D1T7X2, A0A8D1VTE0, A5JVA2, B3XXC2, B6EUP3, F6Q790
      Conserved Domains (6) summary
      smart00082
      Location:761 → 806
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:869 → 1005
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:500 → 521
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:62 → 94
      LRR_8; Leucine rich repeat
      cl26018
      Location:630 → 765
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:154 → 690
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

    7. XM_013985896.2 → XP_013841350.1  toll-like receptor 8 isoform X3

      UniProtKB/TrEMBL
      A0A4X1TK68, A0A8D0XNY5, A0A8D1DWE5, A0A8D1T7X2, A0A8D1VTE0, A5JVA2, B3XXC2, B6EUP3, F6Q790
      Conserved Domains (6) summary
      smart00082
      Location:761 → 806
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:869 → 1005
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:500 → 521
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:62 → 94
      LRR_8; Leucine rich repeat
      cl26018
      Location:630 → 765
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:154 → 690
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

    8. XM_013985894.2 → XP_013841348.1  toll-like receptor 8 isoform X3

      UniProtKB/TrEMBL
      A0A4X1TK68, A0A8D0XNY5, A0A8D1DWE5, A0A8D1T7X2, A0A8D1VTE0, A5JVA2, B3XXC2, B6EUP3, F6Q790
      Conserved Domains (6) summary
      smart00082
      Location:761 → 806
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:869 → 1005
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:500 → 521
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:62 → 94
      LRR_8; Leucine rich repeat
      cl26018
      Location:630 → 765
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:154 → 690
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

    9. XM_005673404.3 → XP_005673461.1  toll-like receptor 8 isoform X3

      See identical proteins and their annotated locations for XP_005673461.1

      UniProtKB/TrEMBL
      A0A4X1TK68, A0A8D0XNY5, A0A8D1DWE5, A0A8D1T7X2, A0A8D1VTE0, A5JVA2, B3XXC2, B6EUP3, F6Q790
      Related
      ENSSSCP00000031310.1, ENSSSCT00000064062.3
      Conserved Domains (6) summary
      smart00082
      Location:761 → 806
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:869 → 1005
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:500 → 521
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:62 → 94
      LRR_8; Leucine rich repeat
      cl26018
      Location:630 → 765
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:154 → 690
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

    10. XM_005673405.3 → XP_005673462.1  toll-like receptor 8 isoform X3

      See identical proteins and their annotated locations for XP_005673462.1

      UniProtKB/TrEMBL
      A0A4X1TK68, A0A8D0XNY5, A0A8D1DWE5, A0A8D1T7X2, A0A8D1VTE0, A5JVA2, B3XXC2, B6EUP3, F6Q790
      Related
      ENSSSCP00000030972.1, ENSSSCT00000033711.4
      Conserved Domains (6) summary
      smart00082
      Location:761 → 806
      LRRCT; Leucine rich repeat C-terminal domain
      smart00255
      Location:869 → 1005
      TIR; Toll - interleukin 1 - resistance
      sd00033
      Location:500 → 521
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:62 → 94
      LRR_8; Leucine rich repeat
      cl26018
      Location:630 → 765
      NEL; C-terminal novel E3 ligase, LRR-interacting
      cl26793
      Location:154 → 690
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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