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    FABP1 fatty acid binding protein 1 [ Gallus gallus (chicken) ]

    Gene ID: 374015, updated on 5-Mar-2024

    Summary

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    Official Symbol
    FABP1provided by CGNC
    Official Full Name
    fatty acid binding protein 1provided by CGNC
    Primary source
    CGNC:11895
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    LFABP; L-FABP
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 4 NC_052535.1 (85612157..85615889, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 4 NC_052576.1 (85415911..85419643, complement)

    Chromosome 4 - NC_052535.1Genomic Context describing neighboring genes Neighboring gene zinc finger matrin-type protein 1-like Neighboring gene SET and MYND domain containing 1 Neighboring gene threonine synthase like 2 Neighboring gene uncharacterized LOC121110756

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cold stress initiates the Nrf2/UGT1A1/L-FABP signaling pathway in chickens. Chen XY, et al. Poult Sci, 2015 Nov. PMID 26453599
    2. Role of a liver fatty acid-binding protein gene in lipid metabolism in chicken hepatocytes. Gao GL, et al. Genet Mol Res, 2015 May 11. PMID 25966259
    3. [Whole cDNA sequence cloning and expression of chicken L-FABP gene and its relationship with lipid deposition of hybrid chickens]. Yu Y, et al. Yi Chuan, 2011 Jul. PMID 22049691
    4. Differential expression of L-FABP and L-BABP between fat and lean chickens. Zhang Q, et al. Genet Mol Res, 2013 Oct 7. PMID 24114214
    5. Characterization of critical factors influencing gene expression of two types of fatty acid-binding proteins (L-FABP and Lb-FABP) in the liver of birds. Murai A, et al. Comp Biochem Physiol A Mol Integr Physiol, 2009 Oct. PMID 19540927

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. L-FABP may affect lipid metabolism by regulating PPARalpha and L-BABP in chicken hepatocytes.
      Title: Role of a liver fatty acid-binding protein gene in lipid metabolism in chicken hepatocytes.
    2. Chickens under cold stress generate anti-oxidative stress and trigger the Nrf2/ARE signaling pathway, which further up-regulates L-FABP expression to inactivate cell membrane lipid peroxidation and promote fatty acid storage against the cold environment.
      Title: Cold stress initiates the Nrf2/UGT1A1/L-FABP signaling pathway in chickens.
    3. A high expression level of L-FABP and L-BABP leads to a high lipogenesis rate and, ultimately, to lipid deposition.
      Title: Differential expression of L-FABP and L-BABP between fat and lean chickens.
    4. The L-FABP gene was over-expressed in the liver tissue and contributed to the increased lipid deposition.
      Title: [Whole cDNA sequence cloning and expression of chicken L-FABP gene and its relationship with lipid deposition of hybrid chickens].
    5. investigation of the gene expression levels of L-FABP and Lb-FABP in relation to the pre-and post-hatching development, diurnal cycle and feeding state in the liver
      Title: Characterization of critical factors influencing gene expression of two types of fatty acid-binding proteins (L-FABP and Lb-FABP) in the liver of birds.
    6. The crystal structure of chicken liver basic type FABP complexed with cholic acid reveals that the FABP holoprotein and apoprotein crystallize in different space groups, and significant changes are observed between the two conformations.
      Title: Crystal structure of chicken liver basic fatty acid-binding protein complexed with cholic acid.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables fatty acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fatty acid-binding protein, liver
    Names
    fatty acid binding protein 1, liver
    fatty acid-binding protein
    liver fatty acid binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204192.4 → NP_989523.1  fatty acid-binding protein, liver

      See identical proteins and their annotated locations for NP_989523.1

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000077
      UniProtKB/TrEMBL
      Q90WA9
      Conserved Domains (1) summary
      cd19444
      Location:2 → 127
      FABP1; fatty acid-binding protein 1

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      85612157..85615889 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      85415911..85419643 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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