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    MEP1B meprin A subunit beta [ Ovis aries (sheep) ]

    Gene ID: 101114072, updated on 8-Mar-2024

    Summary

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    Gene symbol
    MEP1B
    Gene description
    meprin A subunit beta
    See related
    EnsemblRapid:ENSOARG00020024493
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Ovis aries
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 23
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 23 NC_056076.1 (25320812..25356245, complement)

    Chromosome 23 - NC_056076.1Genomic Context describing neighboring genes Neighboring gene GRB2 associated regulator of MAPK1 subtype 1 Neighboring gene uncharacterized LOC132658496 Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene ring finger protein 138 Neighboring gene uncharacterized LOC132658495

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_056076.1 Chromosome 23 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    meprin A subunit beta
    Names
    meprin A, beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Genomic

    1. NC_056076.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

      Range
      25320812..25356245 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_060405380.1 → XP_060261363.1  meprin A subunit beta isoform X6

    2. XM_042239188.1 → XP_042095122.1  meprin A subunit beta isoform X5

      Conserved Domains (4) summary
      smart00137
      Location:176 → 343
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00054
      Location:518 → 559
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cl02446
      Location:343 → 502
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      cl00064
      Location:1 → 171
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

    3. XM_042239182.1 → XP_042095116.1  meprin A subunit beta isoform X2

      Conserved Domains (4) summary
      smart00137
      Location:225 → 392
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00054
      Location:567 → 608
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cl02446
      Location:392 → 551
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      cl00064
      Location:44 → 220
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

    4. XM_042239184.1 → XP_042095118.1  meprin A subunit beta isoform X3

      Conserved Domains (4) summary
      smart00137
      Location:207 → 374
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00054
      Location:549 → 590
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cl02446
      Location:374 → 533
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      cl00064
      Location:2 → 202
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

    5. XM_060405382.1 → XP_060261365.1  meprin A subunit beta isoform X7

    6. XM_042239187.1 → XP_042095121.1  meprin A subunit beta isoform X5

      Conserved Domains (4) summary
      smart00137
      Location:176 → 343
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00054
      Location:518 → 559
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cl02446
      Location:343 → 502
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      cl00064
      Location:1 → 171
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

    7. XM_042239186.1 → XP_042095120.1  meprin A subunit beta isoform X4

      Conserved Domains (4) summary
      smart00137
      Location:206 → 373
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00054
      Location:548 → 589
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cl02446
      Location:373 → 532
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      cl00064
      Location:25 → 201
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

    8. XM_042239183.1 → XP_042095117.1  meprin A subunit beta isoform X3

      Conserved Domains (4) summary
      smart00137
      Location:207 → 374
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00054
      Location:549 → 590
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cl02446
      Location:374 → 533
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      cl00064
      Location:2 → 202
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

    9. XM_060405381.1 → XP_060261364.1  meprin A subunit beta isoform X7

    10. XM_042239185.1 → XP_042095119.1  meprin A subunit beta isoform X4

      Conserved Domains (4) summary
      smart00137
      Location:206 → 373
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00054
      Location:548 → 589
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cl02446
      Location:373 → 532
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      cl00064
      Location:25 → 201
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

    11. XM_004020447.5 → XP_004020496.1  meprin A subunit beta isoform X1

      See identical proteins and their annotated locations for XP_004020496.1

      UniProtKB/TrEMBL
      A0A6P3EDU9, W5P7X2
      Related
      ENSOARP00020038188.1, ENSOART00020038331.2
      Conserved Domains (6) summary
      cd06263
      Location:265 → 427
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      cd00054
      Location:602 → 643
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00629
      Location:265 → 429
      MAM; MAM domain, meprin/A5/mu
      pfam01400
      Location:69 → 257
      Astacin; Astacin (Peptidase family M12A)
      cl00064
      Location:27 → 255
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
      cl02446
      Location:427 → 586
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...

    12. XM_060405379.1 → XP_060261362.1  meprin A subunit beta isoform X5

    13. XM_042239189.1 → XP_042095123.1  meprin A subunit beta isoform X8

      Conserved Domains (4) summary
      smart00137
      Location:126 → 293
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      cd00054
      Location:468 → 509
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cl02446
      Location:293 → 452
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...
      cl00064
      Location:2 → 121
      ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...
    Nucleotide Protein Strain
    Heading Accession and Version

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