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    THRB thyroid hormone receptor beta [ Gallus gallus (chicken) ]

    Gene ID: 396431, updated on 17-Aug-2024

    Summary

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    Symbol
    THRBprovided by CGNC
    Full Name
    thyroid hormone receptor betaprovided by CGNC
    Primary source
    CGNC:49800
    See related
    Ensembl:ENSGALG00010001557
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    NR1A2; TR-BETA; CTR BETA 2
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (37164426..37332785, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (37215664..37384021, complement)

    Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene NFKB inhibitor interacting Ras like 1 Neighboring gene ribosomal protein L15 Neighboring gene nuclear receptor subfamily 1 group D member 2 Neighboring gene uncharacterized LOC121109993 Neighboring gene retinoic acid receptor beta Neighboring gene uncharacterized LOC112531715 Neighboring gene topoisomerase (DNA) II beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Thyroid hormone receptor beta2 is strongly up-regulated at all levels of the hypothalamo-pituitary-thyroidal axis during late embryogenesis in chicken. Grommen SV, et al. J Endocrinol, 2008 Mar. PMID 18310447
    2. The use of real-time PCR to study the expression of thyroid hormone receptor beta 2 in the developing chicken. Grommen SV, et al. Ann N Y Acad Sci, 2005 Apr. PMID 15891053
    3. Molecular cloning and sequencing of a cDNA encoding a beta-thyroid hormone receptor in muscovy duckling. Lachuer J, et al. Biochim Biophys Acta, 1996 Jan 10. PMID 9244185
    4. Contrasting developmental and tissue-specific expression of alpha and beta thyroid hormone receptor genes. Forrest D, et al. EMBO J, 1990 May. PMID 1970296, Free PMC Article
    5. Isolation and characterization of a cDNA encoding a chicken beta thyroid hormone receptor. Showers MO, et al. DNA Cell Biol, 1991 Apr. PMID 1707280

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. changes occur in thyroid hormone (TH) receptor beta2 (TRbeta2) expression at the different levels of the hypothalamo-pituitary-thyroidal (HPT) axis during the last week of chicken embryonic development and hatching
      Title: Thyroid hormone receptor beta2 is strongly up-regulated at all levels of the hypothalamo-pituitary-thyroidal axis during late embryogenesis in chicken.
    2. Thyroid hormone receptor beta 2 mRNA is more abundant in the pituitary of newly hatched chicks than in 15-day-old embryos.
      Title: The use of real-time PCR to study the expression of thyroid hormone receptor beta 2 in the developing chicken.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in retinoic acid receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in thyroid hormone receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thyroid hormone receptor beta
    Names
    C-ERBA-BETA
    beta-thyroid hormone receptor
    nuclear receptor subfamily 1 group A member 2
    thyroid hormone receptor beta 2
    thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252221.2 → NP_001239150.1  thyroid hormone receptor beta isoform 2

      See identical proteins and their annotated locations for NP_001239150.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting protein (isoform 2) is longer and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      BM490757, BU382230, JAENSK010000037
      UniProtKB/TrEMBL
      F1NWE9
      Related
      ENSGALP00010002023.1, ENSGALT00010003592.1
      Conserved Domains (2) summary
      cd06935
      Location:231 → 473
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:121 → 207
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    2. NM_205447.2 → NP_990778.2  thyroid hormone receptor beta isoform 1

      See identical proteins and their annotated locations for NP_990778.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter protein (isoform 1).
      Source sequence(s)
      X17504, Z50188
      UniProtKB/Swiss-Prot
      P68306
      UniProtKB/TrEMBL
      A0A8V0X619
      Related
      ENSGALP00010002032.1, ENSGALT00010003607.1
      Conserved Domains (2) summary
      cd06935
      Location:124 → 366
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:14 → 100
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      37164426..37332785 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040677171.2 → XP_040533105.1  thyroid hormone receptor beta isoform X2

      UniProtKB/Swiss-Prot
      P68306
      UniProtKB/TrEMBL
      A0A8V0X619
      Conserved Domains (2) summary
      cd06935
      Location:124 → 366
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:14 → 100
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    2. XM_046919416.1 → XP_046775372.1  thyroid hormone receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8V0X619, A0A8V0X966

    3. XM_046919437.1 → XP_046775393.1  thyroid hormone receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8V0X619, A0A8V0X966

    4. XM_025147070.3 → XP_025002838.1  thyroid hormone receptor beta isoform X2

      UniProtKB/Swiss-Prot
      P68306
      UniProtKB/TrEMBL
      A0A8V0X619
      Conserved Domains (2) summary
      cd06935
      Location:124 → 366
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:14 → 100
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    5. XM_046919410.1 → XP_046775366.1  thyroid hormone receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8V0X619, A0A8V0X966

    6. XM_040677142.2 → XP_040533076.1  thyroid hormone receptor beta isoform X2

      UniProtKB/Swiss-Prot
      P68306
      UniProtKB/TrEMBL
      A0A8V0X619
      Conserved Domains (2) summary
      cd06935
      Location:124 → 366
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:14 → 100
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    7. XM_046919420.1 → XP_046775376.1  thyroid hormone receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8V0X619, A0A8V0X966

    8. XM_046919447.1 → XP_046775403.1  thyroid hormone receptor beta isoform X2

      UniProtKB/Swiss-Prot
      P68306
      UniProtKB/TrEMBL
      A0A8V0X619

    9. XM_046919407.1 → XP_046775363.1  thyroid hormone receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8V0X619, A0A8V0X966

    10. XM_046919406.1 → XP_046775362.1  thyroid hormone receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8V0X619, A0A8V0X966

    11. XM_025147069.3 → XP_025002837.1  thyroid hormone receptor beta isoform X2

      UniProtKB/Swiss-Prot
      P68306
      UniProtKB/TrEMBL
      A0A8V0X619
      Conserved Domains (2) summary
      cd06935
      Location:124 → 366
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:14 → 100
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    12. XM_046919405.1 → XP_046775361.1  thyroid hormone receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8V0X619, A0A8V0X966

    13. XM_046919446.1 → XP_046775402.1  thyroid hormone receptor beta isoform X2

      UniProtKB/Swiss-Prot
      P68306
      UniProtKB/TrEMBL
      A0A8V0X619

    14. XM_046919411.1 → XP_046775367.1  thyroid hormone receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8V0X619, A0A8V0X966

    15. XM_025147071.3 → XP_025002839.1  thyroid hormone receptor beta isoform X2

      UniProtKB/Swiss-Prot
      P68306
      UniProtKB/TrEMBL
      A0A8V0X619
      Conserved Domains (2) summary
      cd06935
      Location:124 → 366
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:14 → 100
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    16. XM_046919418.1 → XP_046775374.1  thyroid hormone receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8V0X619, A0A8V0X966
      Related
      ENSGALP00010002035.1, ENSGALT00010003612.1

    17. XM_025147072.3 → XP_025002840.1  thyroid hormone receptor beta isoform X2

      UniProtKB/Swiss-Prot
      P68306
      UniProtKB/TrEMBL
      A0A8V0X619
      Conserved Domains (2) summary
      cd06935
      Location:124 → 366
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:14 → 100
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    18. XM_046919403.1 → XP_046775359.1  thyroid hormone receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8V0X619, A0A8V0X966

    19. XM_015281324.4 → XP_015136810.1  thyroid hormone receptor beta isoform X2

      UniProtKB/Swiss-Prot
      P68306
      UniProtKB/TrEMBL
      A0A8V0X619
      Conserved Domains (2) summary
      cd06935
      Location:124 → 366
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:14 → 100
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    20. XM_046919429.1 → XP_046775385.1  thyroid hormone receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8V0X619, A0A8V0X966

    21. XM_046919454.1 → XP_046775410.1  thyroid hormone receptor beta isoform X2

      UniProtKB/Swiss-Prot
      P68306
      UniProtKB/TrEMBL
      A0A8V0X619

    22. XM_046919455.1 → XP_046775411.1  thyroid hormone receptor beta isoform X2

      UniProtKB/Swiss-Prot
      P68306
      UniProtKB/TrEMBL
      A0A8V0X619

    23. XM_025147073.3 → XP_025002841.1  thyroid hormone receptor beta isoform X2

      UniProtKB/Swiss-Prot
      P68306
      UniProtKB/TrEMBL
      A0A8V0X619
      Conserved Domains (2) summary
      cd06935
      Location:124 → 366
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:14 → 100
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    24. XM_046919439.1 → XP_046775395.1  thyroid hormone receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8V0X619, A0A8V0X966

    25. XM_040677133.2 → XP_040533067.1  thyroid hormone receptor beta isoform X2

      UniProtKB/Swiss-Prot
      P68306
      UniProtKB/TrEMBL
      A0A8V0X619
      Conserved Domains (2) summary
      cd06935
      Location:124 → 366
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:14 → 100
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    26. XM_046919431.1 → XP_046775387.1  thyroid hormone receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8V0X619, A0A8V0X966

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      37215664..37384021 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046910544.1 → XP_046766500.1  thyroid hormone receptor beta isoform X2

      UniProtKB/Swiss-Prot
      P68306
      UniProtKB/TrEMBL
      A0A8V0X619

    2. XM_046910530.1 → XP_046766486.1  thyroid hormone receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8V0X619, A0A8V0X966

    3. XM_046910535.1 → XP_046766491.1  thyroid hormone receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8V0X619, A0A8V0X966

    4. XM_046910549.1 → XP_046766505.1  thyroid hormone receptor beta isoform X2

      UniProtKB/Swiss-Prot
      P68306
      UniProtKB/TrEMBL
      A0A8V0X619

    5. XM_046910528.1 → XP_046766484.1  thyroid hormone receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8V0X619, A0A8V0X966

    6. XM_046910542.1 → XP_046766498.1  thyroid hormone receptor beta isoform X2

      UniProtKB/Swiss-Prot
      P68306
      UniProtKB/TrEMBL
      A0A8V0X619

    7. XM_046910532.1 → XP_046766488.1  thyroid hormone receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8V0X619, A0A8V0X966

    8. XM_046910543.1 → XP_046766499.1  thyroid hormone receptor beta isoform X2

      UniProtKB/Swiss-Prot
      P68306
      UniProtKB/TrEMBL
      A0A8V0X619

    9. XM_046910527.1 → XP_046766483.1  thyroid hormone receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8V0X619, A0A8V0X966

    10. XM_046910526.1 → XP_046766482.1  thyroid hormone receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8V0X619, A0A8V0X966

    11. XM_046910540.1 → XP_046766496.1  thyroid hormone receptor beta isoform X2

      UniProtKB/Swiss-Prot
      P68306
      UniProtKB/TrEMBL
      A0A8V0X619

    12. XM_046910525.1 → XP_046766481.1  thyroid hormone receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8V0X619, A0A8V0X966

    13. XM_046910541.1 → XP_046766497.1  thyroid hormone receptor beta isoform X2

      UniProtKB/Swiss-Prot
      P68306
      UniProtKB/TrEMBL
      A0A8V0X619

    14. XM_046910529.1 → XP_046766485.1  thyroid hormone receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8V0X619, A0A8V0X966

    15. XM_046910538.1 → XP_046766494.1  thyroid hormone receptor beta isoform X2

      UniProtKB/Swiss-Prot
      P68306
      UniProtKB/TrEMBL
      A0A8V0X619

    16. XM_046910531.1 → XP_046766487.1  thyroid hormone receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8V0X619, A0A8V0X966

    17. XM_046910539.1 → XP_046766495.1  thyroid hormone receptor beta isoform X2

      UniProtKB/Swiss-Prot
      P68306
      UniProtKB/TrEMBL
      A0A8V0X619

    18. XM_046910524.1 → XP_046766480.1  thyroid hormone receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8V0X619, A0A8V0X966

    19. XM_046910546.1 → XP_046766502.1  thyroid hormone receptor beta isoform X2

      UniProtKB/Swiss-Prot
      P68306
      UniProtKB/TrEMBL
      A0A8V0X619

    20. XM_046910533.1 → XP_046766489.1  thyroid hormone receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8V0X619, A0A8V0X966

    21. XM_046910536.1 → XP_046766492.1  thyroid hormone receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8V0X619, A0A8V0X966

    22. XM_046910547.1 → XP_046766503.1  thyroid hormone receptor beta isoform X2

      UniProtKB/Swiss-Prot
      P68306
      UniProtKB/TrEMBL
      A0A8V0X619

    23. XM_046910548.1 → XP_046766504.1  thyroid hormone receptor beta isoform X2

      UniProtKB/Swiss-Prot
      P68306
      UniProtKB/TrEMBL
      A0A8V0X619

    24. XM_046910550.1 → XP_046766506.1  thyroid hormone receptor beta isoform X2

      UniProtKB/Swiss-Prot
      P68306
      UniProtKB/TrEMBL
      A0A8V0X619

    25. XM_046910537.1 → XP_046766493.1  thyroid hormone receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8V0X619, A0A8V0X966

    26. XM_046910545.1 → XP_046766501.1  thyroid hormone receptor beta isoform X2

      UniProtKB/Swiss-Prot
      P68306
      UniProtKB/TrEMBL
      A0A8V0X619

    27. XM_046910534.1 → XP_046766490.1  thyroid hormone receptor beta isoform X1

      UniProtKB/TrEMBL
      A0A8V0X619, A0A8V0X966
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P68306.1 GenPept UniProtKB/Swiss-Prot:P68306

    Gene LinkOut

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