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    Cdc25b cell division cycle 25B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171103, updated on 2-May-2024

    Summary

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    Official Symbol
    Cdc25bprovided by RGD
    Official Full Name
    cell division cycle 25Bprovided by RGD
    Primary source
    RGD:621500
    See related
    Ensembl:ENSRNOG00000021248 AllianceGenome:RGD:621500
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein kinase binding activity and protein tyrosine phosphatase activity. Involved in mitotic cell cycle. Predicted to be located in centrosome and spindle pole. Predicted to be active in cytoplasm and nucleus. Orthologous to human CDC25B (cell division cycle 25B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 404.3), Lung (RPKM 87.2) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    3q36
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (138860148..138870287)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (118407127..118417272)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (123731539..123741696)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene centromere protein B Neighboring gene uncharacterized LOC134486156 Neighboring gene adaptor related protein complex 5 subunit sigma 1 Neighboring gene mitochondrial antiviral signaling protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Development of a multiplex quantitative PCR signature to predict progression in non-muscle-invasive bladder cancer. Wang R, et al. Cancer Res, 2009 May 1. PMID 19383904, Free PMC Article
    2. Expression of cdc25A and cdc25B phosphatase in breast carcinoma. Ito Y, et al. Breast Cancer, 2004. PMID 15550849
    3. Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation. Lincoln AJ, et al. Nat Genet, 2002 Apr. PMID 11912493
    4. Cdc25A is a novel phosphatase functioning early in the cell cycle. Jinno S, et al. EMBO J, 1994 Apr 1. PMID 8156993, Free PMC Article
    5. The role of 14-3-3ε interaction with phosphorylated Cdc25B at its Ser321 in the release of the mouse oocyte from prophase I arrest. Meng J, et al. PLoS One, 2013. PMID 23326474, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphoprotein phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in female meiosis I IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within female meiosis I ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oocyte maturation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within oocyte maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of G2/M transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of G2/M transition of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of G2/MI transition of meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell cycle G2/M phase transition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cytokinesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    M-phase inducer phosphatase 2
    Names
    dual specificity phosphatase Cdc25B
    NP_001376142.1
    NP_598256.2
    XP_038960121.1
    XP_038960123.1
    XP_063139110.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001389213.1 → NP_001376142.1  M-phase inducer phosphatase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6A7K8, A0A8I6GIX5
      Related
      ENSRNOP00000091343.1, ENSRNOT00000119042.1
      Conserved Domains (2) summary
      cd01530
      Location:381 → 500
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:111 → 352
      M-inducer_phosp; M-phase inducer phosphatase

    2. NM_001429734.1 → NP_001416663.1  M-phase inducer phosphatase 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    3. NM_001429735.1 → NP_001416664.1  M-phase inducer phosphatase 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    4. NM_133572.2 → NP_598256.2  M-phase inducer phosphatase 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P48966
      UniProtKB/TrEMBL
      A6HQC8, F1LQS5
      Related
      ENSRNOP00000051129.3, ENSRNOT00000051064.3
      Conserved Domains (2) summary
      cd01530
      Location:407 → 526
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:111 → 378
      M-inducer_phosp; M-phase inducer phosphatase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      138860148..138870287
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283040.1 → XP_063139110.1  M-phase inducer phosphatase 2 isoform X2

    2. XM_039104193.2 → XP_038960121.1  M-phase inducer phosphatase 2 isoform X1

      UniProtKB/Swiss-Prot
      P48966
      Related
      ENSRNOP00000096779.1
      Conserved Domains (2) summary
      cd01530
      Location:393 → 512
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:111 → 364
      M-inducer_phosp; M-phase inducer phosphatase

    3. XM_039104195.2 → XP_038960123.1  M-phase inducer phosphatase 2 isoform X3

      Conserved Domains (2) summary
      cd01530
      Location:209 → 328
      Cdc25; Cdc25 phosphatases are members of the Rhodanese Homology Domain superfamily. They activate the cell division kinases throughout the cell cycle progression. Cdc25 phosphatases dephosphorylate phosphotyrosine and phosphothreonine residues, in order to ...
      pfam06617
      Location:1 → 180
      M-inducer_phosp; M-phase inducer phosphatase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48966.1 GenPept UniProtKB/Swiss-Prot:P48966

    Gene LinkOut

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