U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    RAPGEF2 Rap guanine nucleotide exchange factor 2 [ Canis lupus familiaris (dog) ]

    Gene ID: 100856359, updated on 8-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    RAPGEF2provided by VGNC
    Official Full Name
    Rap guanine nucleotide exchange factor 2provided by VGNC
    Primary source
    VGNC:VGNC:45347
    See related
    Ensembl:ENSCAFG00845005844
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    NRAPGEP; PDZGEF1; CNrasGEF; PDZ-GEF1; RA-GEF-1
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 15
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 15 NC_051819.1 (56855560..57097663)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 15 NC_006597.4 (56473491..56715382)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 15 NC_049236.1 (56504459..56746362)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 15 NC_049275.1 (56092734..56334363)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 15 NC_049756.1 (56190343..56432335)

    Chromosome 15 - NC_051819.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111098922 Neighboring gene uncharacterized LOC119869341 Neighboring gene uncharacterized LOC111098923 Neighboring gene uncharacterized LOC119869085

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification of a novel beta-catenin-interacting protein. Kawajiri A, et al. Biochem Biophys Res Commun, 2000 Jul 5. PMID 10873669
    2. Genome sequence, comparative analysis and haplotype structure of the domestic dog. Lindblad-Toh K, et al. Nature, 2005 Dec 8. PMID 16341006

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    rap guanine nucleotide exchange factor 2
    Names
    Cyclic nucleotide ras GEF
    Neural RAP guanine nucleotide exchange protein
    PDZ domain-containing guanine nucleotide exchange factor 1
    Rap guanine nucleotide exchange factor (GEF) 2
    Ras/Rap1-associating GEF-1
    nRap GEP

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051819.1 Reference ROS_Cfam_1.0

      Range
      56855560..57097663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038688734.1 → XP_038544662.1  rap guanine nucleotide exchange factor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0Q708, A0A8C0RC58, A0A8I3MWY5
      Related
      ENSCAFP00845008067.1, ENSCAFT00845010380.1
      Conserved Domains (6) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1099
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    2. XM_038688737.1 → XP_038544665.1  rap guanine nucleotide exchange factor 2 isoform X4

      UniProtKB/TrEMBL
      A0A8C0JX01
      Conserved Domains (6) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1099
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    3. XM_038688739.1 → XP_038544667.1  rap guanine nucleotide exchange factor 2 isoform X6

      UniProtKB/TrEMBL
      A0A8C0JVH6, A0A8P0TDX2
      Conserved Domains (6) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1099
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    4. XM_038688736.1 → XP_038544664.1  rap guanine nucleotide exchange factor 2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0M5B2, A0A8C0QG17, A0A8I3MQQ6
      Related
      ENSCAFP00845008208.1, ENSCAFT00845010547.1
      Conserved Domains (6) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1078
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    5. XM_038688735.1 → XP_038544663.1  rap guanine nucleotide exchange factor 2 isoform X2

      UniProtKB/TrEMBL
      A0A8C0MCB1, A0A8C0QFU4, A0A8I3RUE2
      Related
      ENSCAFP00845008133.1, ENSCAFT00845010464.1
      Conserved Domains (6) summary
      smart00100
      Location:291 → 406
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:422 → 535
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:868 → 1093
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:539 → 619
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:763 → 845
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    6. XM_038688740.1 → XP_038544668.1  rap guanine nucleotide exchange factor 2 isoform X7

      UniProtKB/TrEMBL
      A0A8C0JVH6, A0A8C0JVR4
      Conserved Domains (6) summary
      smart00100
      Location:291 → 406
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:422 → 535
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:868 → 1093
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:539 → 619
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:763 → 845
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    7. XM_038688738.1 → XP_038544666.1  rap guanine nucleotide exchange factor 2 isoform X5

      UniProtKB/TrEMBL
      A0A8C0RC58
      Conserved Domains (6) summary
      smart00100
      Location:263 → 378
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:394 → 507
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:3 → 109
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:840 → 1065
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:511 → 591
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:735 → 817
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    8. XM_038688743.1 → XP_038544671.1  rap guanine nucleotide exchange factor 2 isoform X10

      UniProtKB/TrEMBL
      A0A8C0QBI1
      Conserved Domains (5) summary
      smart00100
      Location:181 → 296
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:312 → 425
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:758 → 983
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:429 → 509
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:653 → 735
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    9. XM_038688741.1 → XP_038544669.1  rap guanine nucleotide exchange factor 2 isoform X8

      UniProtKB/TrEMBL
      A0A8C0QB76
      Conserved Domains (5) summary
      smart00100
      Location:207 → 322
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:338 → 451
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:784 → 1009
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:455 → 535
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:679 → 761
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    10. XM_038688742.1 → XP_038544670.1  rap guanine nucleotide exchange factor 2 isoform X9

      UniProtKB/TrEMBL
      A0A8C0QBI1
      Conserved Domains (5) summary
      smart00100
      Location:184 → 299
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:315 → 428
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:761 → 986
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:432 → 512
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:656 → 738
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    11. XM_038688744.1 → XP_038544672.1  rap guanine nucleotide exchange factor 2 isoform X11

      UniProtKB/TrEMBL
      A0A8C0MDA9
      Conserved Domains (5) summary
      smart00100
      Location:136 → 251
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:267 → 380
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:713 → 938
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:384 → 464
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:608 → 690
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    12. XM_038688746.1 → XP_038544674.1  rap guanine nucleotide exchange factor 2 isoform X12

      UniProtKB/TrEMBL
      A0A8C0MDA9
      Conserved Domains (5) summary
      smart00100
      Location:136 → 251
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:267 → 380
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:713 → 938
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:384 → 464
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:608 → 690
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    13. XM_038688747.1 → XP_038544675.1  rap guanine nucleotide exchange factor 2 isoform X13

      UniProtKB/Swiss-Prot
      F1PBJ0
      UniProtKB/TrEMBL
      A0A8C0MDA9, A0A8C0QVI4
      Related
      ENSCAFP00845008308.1, ENSCAFT00845010658.1
      Conserved Domains (5) summary
      smart00100
      Location:136 → 251
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:267 → 380
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:713 → 938
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:384 → 464
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:608 → 690
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049275.1 Alternate UMICH_Zoey_3.1

      Range
      56092734..56334363
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038496727.1 → XP_038352655.1  rap guanine nucleotide exchange factor 2 isoform X3

      Conserved Domains (6) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1078
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    2. XM_038496725.1 → XP_038352653.1  rap guanine nucleotide exchange factor 2 isoform X1

      Conserved Domains (6) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1099
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    3. XM_038496728.1 → XP_038352656.1  rap guanine nucleotide exchange factor 2 isoform X4

      Conserved Domains (6) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1099
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    4. XM_038496730.1 → XP_038352658.1  rap guanine nucleotide exchange factor 2 isoform X6

      Conserved Domains (6) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1099
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    5. XM_038496726.1 → XP_038352654.1  rap guanine nucleotide exchange factor 2 isoform X2

      Conserved Domains (6) summary
      smart00100
      Location:291 → 406
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:422 → 535
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:868 → 1093
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:539 → 619
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:763 → 845
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    6. XM_038496731.1 → XP_038352659.1  rap guanine nucleotide exchange factor 2 isoform X7

      Conserved Domains (6) summary
      smart00100
      Location:291 → 406
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:422 → 535
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:868 → 1093
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:539 → 619
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:763 → 845
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    7. XM_038496729.1 → XP_038352657.1  rap guanine nucleotide exchange factor 2 isoform X5

      Conserved Domains (6) summary
      smart00100
      Location:263 → 378
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:394 → 507
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:3 → 109
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:840 → 1065
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:511 → 591
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:735 → 817
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    8. XM_038496734.1 → XP_038352662.1  rap guanine nucleotide exchange factor 2 isoform X10

      Conserved Domains (5) summary
      smart00100
      Location:181 → 296
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:312 → 425
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:758 → 983
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:429 → 509
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:653 → 735
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    9. XM_038496732.1 → XP_038352660.1  rap guanine nucleotide exchange factor 2 isoform X8

      Conserved Domains (5) summary
      smart00100
      Location:207 → 322
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:338 → 451
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:784 → 1009
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:455 → 535
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:679 → 761
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    10. XM_038496733.1 → XP_038352661.1  rap guanine nucleotide exchange factor 2 isoform X9

      Conserved Domains (5) summary
      smart00100
      Location:184 → 299
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:315 → 428
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:761 → 986
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:432 → 512
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:656 → 738
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    11. XM_038496735.1 → XP_038352663.1  rap guanine nucleotide exchange factor 2 isoform X11

      Conserved Domains (5) summary
      smart00100
      Location:136 → 251
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:267 → 380
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:713 → 938
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:384 → 464
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:608 → 690
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    12. XM_038496736.1 → XP_038352664.1  rap guanine nucleotide exchange factor 2 isoform X12

      Conserved Domains (5) summary
      smart00100
      Location:136 → 251
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:267 → 380
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:713 → 938
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:384 → 464
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:608 → 690
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    13. XM_038496737.1 → XP_038352665.1  rap guanine nucleotide exchange factor 2 isoform X13

      Conserved Domains (5) summary
      smart00100
      Location:136 → 251
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:267 → 380
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:713 → 938
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:384 → 464
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:608 → 690
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049756.1 Alternate UNSW_CanFamBas_1.0

      Range
      56190343..56432335
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038623066.1 → XP_038478994.1  rap guanine nucleotide exchange factor 2 isoform X3

    2. XM_038623064.1 → XP_038478992.1  rap guanine nucleotide exchange factor 2 isoform X1

    3. XM_038623067.1 → XP_038478995.1  rap guanine nucleotide exchange factor 2 isoform X4

    4. XM_038623069.1 → XP_038478997.1  rap guanine nucleotide exchange factor 2 isoform X6

    5. XM_038623065.1 → XP_038478993.1  rap guanine nucleotide exchange factor 2 isoform X2

    6. XM_038623070.1 → XP_038478998.1  rap guanine nucleotide exchange factor 2 isoform X7

    7. XM_038623068.1 → XP_038478996.1  rap guanine nucleotide exchange factor 2 isoform X5

    8. XM_038623073.1 → XP_038479001.1  rap guanine nucleotide exchange factor 2 isoform X10

    9. XM_038623071.1 → XP_038478999.1  rap guanine nucleotide exchange factor 2 isoform X8

    10. XM_038623072.1 → XP_038479000.1  rap guanine nucleotide exchange factor 2 isoform X9

    11. XM_038623074.1 → XP_038479002.1  rap guanine nucleotide exchange factor 2 isoform X11

    12. XM_038623075.1 → XP_038479003.1  rap guanine nucleotide exchange factor 2 isoform X12

    13. XM_038623076.1 → XP_038479004.1  rap guanine nucleotide exchange factor 2 isoform X13

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049236.1 Alternate UU_Cfam_GSD_1.0

      Range
      56504459..56746362
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038559121.1 → XP_038415049.1  rap guanine nucleotide exchange factor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0Q708, A0A8C0RC58, A0A8I3MWY5
      Conserved Domains (6) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1099
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    2. XM_038559124.1 → XP_038415052.1  rap guanine nucleotide exchange factor 2 isoform X4

      UniProtKB/TrEMBL
      A0A8C0JX01
      Conserved Domains (6) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1099
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    3. XM_038559126.1 → XP_038415054.1  rap guanine nucleotide exchange factor 2 isoform X6

      UniProtKB/TrEMBL
      A0A8C0JVH6, A0A8P0TDX2
      Conserved Domains (6) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1099
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    4. XM_038559123.1 → XP_038415051.1  rap guanine nucleotide exchange factor 2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0M5B2, A0A8C0QG17, A0A8I3MQQ6
      Conserved Domains (6) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1078
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    5. XM_038559122.1 → XP_038415050.1  rap guanine nucleotide exchange factor 2 isoform X2

      UniProtKB/TrEMBL
      A0A8C0MCB1, A0A8C0QFU4, A0A8I3RUE2
      Conserved Domains (6) summary
      smart00100
      Location:291 → 406
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:422 → 535
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:868 → 1093
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:539 → 619
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:763 → 845
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    6. XM_038559127.1 → XP_038415055.1  rap guanine nucleotide exchange factor 2 isoform X7

      UniProtKB/TrEMBL
      A0A8C0JVH6, A0A8C0JVR4
      Conserved Domains (6) summary
      smart00100
      Location:291 → 406
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:422 → 535
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:868 → 1093
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:539 → 619
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:763 → 845
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    7. XM_038559125.1 → XP_038415053.1  rap guanine nucleotide exchange factor 2 isoform X5

      UniProtKB/TrEMBL
      A0A8C0RC58
      Conserved Domains (6) summary
      smart00100
      Location:263 → 378
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:394 → 507
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:3 → 109
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:840 → 1065
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:511 → 591
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:735 → 817
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    8. XM_038559130.1 → XP_038415058.1  rap guanine nucleotide exchange factor 2 isoform X10

      UniProtKB/TrEMBL
      A0A8C0QBI1
      Conserved Domains (5) summary
      smart00100
      Location:181 → 296
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:312 → 425
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:758 → 983
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:429 → 509
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:653 → 735
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    9. XM_038559128.1 → XP_038415056.1  rap guanine nucleotide exchange factor 2 isoform X8

      UniProtKB/TrEMBL
      A0A8C0QB76
      Conserved Domains (5) summary
      smart00100
      Location:207 → 322
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:338 → 451
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:784 → 1009
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:455 → 535
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:679 → 761
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    10. XM_038559129.1 → XP_038415057.1  rap guanine nucleotide exchange factor 2 isoform X9

      UniProtKB/TrEMBL
      A0A8C0QBI1
      Conserved Domains (5) summary
      smart00100
      Location:184 → 299
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:315 → 428
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:761 → 986
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:432 → 512
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:656 → 738
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    11. XM_038559131.1 → XP_038415059.1  rap guanine nucleotide exchange factor 2 isoform X11

      UniProtKB/TrEMBL
      A0A8C0MDA9
      Conserved Domains (5) summary
      smart00100
      Location:136 → 251
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:267 → 380
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:713 → 938
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:384 → 464
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:608 → 690
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    12. XM_038559132.1 → XP_038415060.1  rap guanine nucleotide exchange factor 2 isoform X12

      UniProtKB/TrEMBL
      A0A8C0MDA9
      Conserved Domains (5) summary
      smart00100
      Location:136 → 251
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:267 → 380
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:713 → 938
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:384 → 464
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:608 → 690
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    13. XM_038559133.1 → XP_038415061.1  rap guanine nucleotide exchange factor 2 isoform X13

      UniProtKB/Swiss-Prot
      F1PBJ0
      UniProtKB/TrEMBL
      A0A8C0MDA9, A0A8C0QVI4
      Conserved Domains (5) summary
      smart00100
      Location:136 → 251
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:267 → 380
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:713 → 938
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:384 → 464
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:608 → 690
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006597.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      56473491..56715382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038448961.1 → XP_038304889.1  rap guanine nucleotide exchange factor 2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0Q708, A0A8C0RC58, A0A8I3MWY5
      Conserved Domains (6) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1099
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    2. XM_038448973.1 → XP_038304901.1  rap guanine nucleotide exchange factor 2 isoform X4

      UniProtKB/TrEMBL
      A0A8C0JX01
      Conserved Domains (6) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1099
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    3. XM_038448989.1 → XP_038304917.1  rap guanine nucleotide exchange factor 2 isoform X6

      UniProtKB/TrEMBL
      A0A8C0JVH6, A0A8P0TDX2
      Conserved Domains (6) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1099
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    4. XM_038448968.1 → XP_038304896.1  rap guanine nucleotide exchange factor 2 isoform X3

      UniProtKB/TrEMBL
      A0A8C0M5B2, A0A8C0QG17, A0A8I3MQQ6
      Conserved Domains (6) summary
      smart00100
      Location:297 → 412
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:428 → 541
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:874 → 1078
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:545 → 625
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:769 → 851
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    5. XM_038448966.1 → XP_038304894.1  rap guanine nucleotide exchange factor 2 isoform X2

      UniProtKB/TrEMBL
      A0A8C0MCB1, A0A8C0QFU4, A0A8I3RUE2
      Conserved Domains (6) summary
      smart00100
      Location:291 → 406
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:422 → 535
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:868 → 1093
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:539 → 619
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:763 → 845
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    6. XM_038448993.1 → XP_038304921.1  rap guanine nucleotide exchange factor 2 isoform X7

      UniProtKB/TrEMBL
      A0A8C0JVH6, A0A8C0JVR4
      Conserved Domains (6) summary
      smart00100
      Location:291 → 406
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:422 → 535
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:37 → 143
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:868 → 1093
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:539 → 619
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:763 → 845
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    7. XM_038448981.1 → XP_038304909.1  rap guanine nucleotide exchange factor 2 isoform X5

      UniProtKB/TrEMBL
      A0A8C0RC58
      Conserved Domains (6) summary
      smart00100
      Location:263 → 378
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:394 → 507
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00038
      Location:3 → 109
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd00155
      Location:840 → 1065
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:511 → 591
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:735 → 817
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    8. XM_014119399.3 → XP_013974874.1  rap guanine nucleotide exchange factor 2 isoform X10

      UniProtKB/TrEMBL
      A0A8C0QBI1
      Conserved Domains (5) summary
      smart00100
      Location:181 → 296
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:312 → 425
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:758 → 983
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:429 → 509
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:653 → 735
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    9. XM_014119398.3 → XP_013974873.1  rap guanine nucleotide exchange factor 2 isoform X8

      UniProtKB/TrEMBL
      A0A8C0QB76
      Conserved Domains (5) summary
      smart00100
      Location:207 → 322
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:338 → 451
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:784 → 1009
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:455 → 535
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:679 → 761
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    10. XM_038449004.1 → XP_038304932.1  rap guanine nucleotide exchange factor 2 isoform X9

      UniProtKB/TrEMBL
      A0A8C0QBI1
      Conserved Domains (5) summary
      smart00100
      Location:184 → 299
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:315 → 428
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:761 → 986
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:432 → 512
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:656 → 738
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    11. XM_005629386.4 → XP_005629443.1  rap guanine nucleotide exchange factor 2 isoform X11

      UniProtKB/TrEMBL
      A0A8C0MDA9
      Conserved Domains (5) summary
      smart00100
      Location:136 → 251
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:267 → 380
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:713 → 938
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:384 → 464
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:608 → 690
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    12. XM_022403559.2 → XP_022259267.1  rap guanine nucleotide exchange factor 2 isoform X12

      UniProtKB/TrEMBL
      A0A8C0MDA9
      Conserved Domains (5) summary
      smart00100
      Location:136 → 251
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:267 → 380
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:713 → 938
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:384 → 464
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:608 → 690
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

    13. XM_003639497.5 → XP_003639545.1  rap guanine nucleotide exchange factor 2 isoform X13

      See identical proteins and their annotated locations for XP_003639545.1

      UniProtKB/Swiss-Prot
      F1PBJ0
      UniProtKB/TrEMBL
      A0A8C0MDA9, A0A8C0QVI4
      Conserved Domains (5) summary
      smart00100
      Location:136 → 251
      cNMP; Cyclic nucleotide-monophosphate binding domain
      smart00229
      Location:267 → 380
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:713 → 938
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00992
      Location:384 → 464
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01785
      Location:608 → 690
      RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1PBJ0.2 GenPept UniProtKB/Swiss-Prot:F1PBJ0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.