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    Art5 ADP-ribosyltransferase 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 259167, updated on 25-Apr-2024

    Summary

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    Official Symbol
    Art5provided by RGD
    Official Full Name
    ADP-ribosyltransferase 5provided by RGD
    Primary source
    RGD:628834
    See related
    Ensembl:ENSRNOG00000020242 AllianceGenome:RGD:628834
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ARTC5
    Summary
    Predicted to enable NAD+ ADP-ribosyltransferase activity and NAD+ nucleosidase activity. Predicted to be involved in peptidyl-arginine ADP-ribosylation. Predicted to act upstream of or within protein ADP-ribosylation. Predicted to be located in extracellular region and membrane. Orthologous to human ART5 (ADP-ribosyltransferase 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 238.1), Testes (RPKM 33.8) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1q32
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (165885344..165895306, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (156473362..156483324, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (167192809..167202767, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 121 Neighboring gene Xrcc1 N-terminal domain containing 1 Neighboring gene transient receptor potential cation channel subfamily C member 2 Neighboring gene ADP-ribosyltransferase 1 Neighboring gene cholinergic receptor nicotinic alpha 10 subunit Neighboring gene nucleoporin 98 and 96 precursor Neighboring gene glutathione peroxidase 4, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a novel membrane-associated lymphocyte NAD:arginine ADP-ribosyltransferase. Okazaki IJ, et al. J Biol Chem, 1996 Sep 6. PMID 8703012
    2. Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5. Glowacki G, et al. Gene, 2001 Sep 19. PMID 11587854
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NAD+ ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+-protein-arginine ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ecto-ADP-ribosyltransferase 5
    Names
    ADP-ribosyltransferase C2 and C3 toxin-like 5
    NAD(P)(+)--arginine ADP-ribosyltransferase 5
    mono(ADP-ribosyl)transferase 5
    NP_001013057.1
    XP_006229907.1
    XP_017444328.1
    XP_038958275.1
    XP_038958304.1
    XP_038958309.1
    XP_038958319.1
    XP_063138431.1
    XP_063138435.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013039.1 → NP_001013057.1  ecto-ADP-ribosyltransferase 5 precursor

      See identical proteins and their annotated locations for NP_001013057.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083915
      UniProtKB/Swiss-Prot
      Q5XHY4
      Conserved Domains (1) summary
      pfam01129
      Location:29 → 255
      ART; NAD:arginine ADP-ribosyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      165885344..165895306 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229845.5 → XP_006229907.1  ecto-ADP-ribosyltransferase 5 isoform X1

      See identical proteins and their annotated locations for XP_006229907.1

      UniProtKB/TrEMBL
      A0A8L2QQ22, A6I715
      Conserved Domains (1) summary
      pfam01129
      Location:29 → 255
      ART; NAD:arginine ADP-ribosyltransferase

    2. XM_039102376.2 → XP_038958304.1  ecto-ADP-ribosyltransferase 5 isoform X3

      Conserved Domains (1) summary
      pfam01129
      Location:1 → 209
      ART; NAD:arginine ADP-ribosyltransferase

    3. XM_039102391.2 → XP_038958319.1  ecto-ADP-ribosyltransferase 5 isoform X5

      Conserved Domains (1) summary
      cl00173
      Location:29 → 202
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    4. XM_039102381.2 → XP_038958309.1  ecto-ADP-ribosyltransferase 5 isoform X4

      Conserved Domains (1) summary
      cl00173
      Location:29 → 209
      VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

    5. XM_063282361.1 → XP_063138431.1  ecto-ADP-ribosyltransferase 5 isoform X2

      UniProtKB/Swiss-Prot
      Q5XHY4

    6. XM_039102347.2 → XP_038958275.1  ecto-ADP-ribosyltransferase 5 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QQ22, A6I715
      Conserved Domains (1) summary
      pfam01129
      Location:29 → 255
      ART; NAD:arginine ADP-ribosyltransferase

    7. XM_017588839.3 → XP_017444328.1  ecto-ADP-ribosyltransferase 5 isoform X2

      UniProtKB/Swiss-Prot
      Q5XHY4
      Conserved Domains (1) summary
      pfam01129
      Location:29 → 255
      ART; NAD:arginine ADP-ribosyltransferase

    8. XM_063282365.1 → XP_063138435.1  ecto-ADP-ribosyltransferase 5 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XHY4.1 GenPept UniProtKB/Swiss-Prot:Q5XHY4

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