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    USP25 ubiquitin specific peptidase 25 [ Bos taurus (cattle) ]

    Gene ID: 524531, updated on 5-Mar-2024

    Summary

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    Official Symbol
    USP25provided by VGNC
    Official Full Name
    ubiquitin specific peptidase 25provided by VGNC
    Primary source
    VGNC:VGNC:36718
    See related
    BGD:BT23108; Ensembl:ENSBTAG00000019314
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (21166756..21328130, complement)

    Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132345457 Neighboring gene microRNA let-7c Neighboring gene microRNA mir-99a Neighboring gene small ribosomal subunit protein uS2-like Neighboring gene transfer RNA tryptophan (anticodon CCA)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of protein stability IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 25
    XP_002684692.2
    XP_005201215.1
    XP_005201216.1
    XP_010799247.1
    XP_010799248.1
    XP_010799249.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      21166756..21328130 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002684646.7 → XP_002684692.2  ubiquitin carboxyl-terminal hydrolase 25 isoform X6

      See identical proteins and their annotated locations for XP_002684692.2

      Conserved Domains (3) summary
      cd02665
      Location:170 → 655
      Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14354
      Location:15 → 60
      UBA_UBP25; UBA domain found in ubiquitin carboxyl-terminal hydrolase 25 (UBP25) and similar proteins
      cl02553
      Location:168 → 298
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

    2. XM_005201159.5 → XP_005201216.1  ubiquitin carboxyl-terminal hydrolase 25 isoform X4

      See identical proteins and their annotated locations for XP_005201216.1

      Related
      ENSBTAP00000058339.2, ENSBTAT00000067413.2
      Conserved Domains (3) summary
      cd02665
      Location:170 → 655
      Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14354
      Location:15 → 60
      UBA_UBP25; UBA domain found in ubiquitin carboxyl-terminal hydrolase 25 (UBP25) and similar proteins
      pfam00443
      Location:168 → 405
      UCH; Ubiquitin carboxyl-terminal hydrolase

    3. XM_005201158.5 → XP_005201215.1  ubiquitin carboxyl-terminal hydrolase 25 isoform X2

      See identical proteins and their annotated locations for XP_005201215.1

      UniProtKB/TrEMBL
      A0A3Q1MMX0
      Related
      ENSBTAP00000081305.1, ENSBTAT00000109948.1
      Conserved Domains (3) summary
      cd02665
      Location:170 → 655
      Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14354
      Location:15 → 60
      UBA_UBP25; UBA domain found in ubiquitin carboxyl-terminal hydrolase 25 (UBP25) and similar proteins
      cl02553
      Location:168 → 298
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

    4. XM_010800947.4 → XP_010799249.1  ubiquitin carboxyl-terminal hydrolase 25 isoform X5

      See identical proteins and their annotated locations for XP_010799249.1

      UniProtKB/TrEMBL
      F1MP13
      Related
      ENSBTAP00000025716.5, ENSBTAT00000025716.6
      Conserved Domains (3) summary
      cd02665
      Location:198 → 683
      Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14354
      Location:15 → 60
      UBA_UBP25; UBA domain found in ubiquitin carboxyl-terminal hydrolase 25 (UBP25) and similar proteins
      cl02553
      Location:196 → 326
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

    5. XM_010800946.4 → XP_010799248.1  ubiquitin carboxyl-terminal hydrolase 25 isoform X3

      See identical proteins and their annotated locations for XP_010799248.1

      UniProtKB/TrEMBL
      A0A3Q1LHR5
      Conserved Domains (3) summary
      cd02665
      Location:198 → 683
      Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14354
      Location:15 → 60
      UBA_UBP25; UBA domain found in ubiquitin carboxyl-terminal hydrolase 25 (UBP25) and similar proteins
      pfam00443
      Location:196 → 433
      UCH; Ubiquitin carboxyl-terminal hydrolase

    6. XM_010800945.4 → XP_010799247.1  ubiquitin carboxyl-terminal hydrolase 25 isoform X1

      See identical proteins and their annotated locations for XP_010799247.1

      Conserved Domains (3) summary
      cd02665
      Location:198 → 683
      Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cd14354
      Location:15 → 60
      UBA_UBP25; UBA domain found in ubiquitin carboxyl-terminal hydrolase 25 (UBP25) and similar proteins
      cl02553
      Location:196 → 326
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    Nucleotide Protein Strain
    Heading Accession and Version

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