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Usp25 ubiquitin specific peptidase 25 [ Mus musculus (house mouse) ]

Gene ID: 30940, updated on 13-Dec-2022

Summary

Official Symbol
Usp25provided by MGI
Official Full Name
ubiquitin specific peptidase 25provided by MGI
Primary source
MGI:MGI:1353655
See related
Ensembl:ENSMUSG00000022867 AllianceGenome:MGI:1353655
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable SUMO binding activity; cysteine-type peptidase activity; and enzyme binding activity. Involved in several processes, including interleukin-17-mediated signaling pathway; intracellular signal transduction; and mRNA metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be part of proteasome complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; musculature; nervous system; and sensory organ. Orthologous to human USP25 (ubiquitin specific peptidase 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 19.3), liver E14.5 (RPKM 16.8) and 28 other tissues See more
Orthologs
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Genomic context

See Usp25 in Genome Data Viewer
Location:
16; 16 C3.1
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (76810573..76913671)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (77013684..77116783)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L19 pseudogene Neighboring gene RIKEN cDNA 1700041M19 gene Neighboring gene predicted gene, 31258 Neighboring gene Mir99a and Mirlet7c-1 host gene (non-protein coding) Neighboring gene RIKEN cDNA 9430053O09 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (2) 
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
 
enables SUMO binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SUMO binding ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in I-kappaB phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chemokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in interleukin-17-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in interleukin-17-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of ERAD pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K48-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K63-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein deubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stress-activated protein kinase signaling cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of proteasome complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 25
Names
deubiquitinating enzyme 25
mUSP25
ubiquitin specific protease 25
ubiquitin thioesterase 25
ubiquitin thiolesterase 25
ubiquitin-specific-processing protease 25
NP_038946.2
XP_006523118.1
XP_006523119.1
XP_006523120.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013918.2NP_038946.2  ubiquitin carboxyl-terminal hydrolase 25

    See identical proteins and their annotated locations for NP_038946.2

    Status: PROVISIONAL

    Source sequence(s)
    BC048171
    Consensus CDS
    CCDS28275.1
    UniProtKB/Swiss-Prot
    P57080, Q80ZT9
    Related
    ENSMUSP00000023580.7, ENSMUST00000023580.8
    Conserved Domains (4) summary
    cd02665
    Location:170656
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd14354
    Location:1560
    UBA_UBP25; UBA domain found in ubiquitin carboxyl-terminal hydrolase 25 (UBP25) and similar proteins
    cl02553
    Location:527642
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:168405
    UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    76810573..76913671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523056.3XP_006523119.1  ubiquitin carboxyl-terminal hydrolase 25 isoform X2

    UniProtKB/TrEMBL
    A0A5F8MPP4
    Related
    ENSMUSP00000159060.2, ENSMUST00000239066.2
    Conserved Domains (4) summary
    COG5207
    Location:169637
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    cd02665
    Location:170656
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd14354
    Location:1560
    UBA_UBP25; UBA domain found in ubiquitin carboxyl-terminal hydrolase 25 (UBP25) and similar proteins
    cd20486
    Location:8381118
    USP25_C; carboxyl-terminal domain of ubiquitin-specific protease 25 (USP25)
  2. XM_006523055.4XP_006523118.1  ubiquitin carboxyl-terminal hydrolase 25 isoform X1

    Conserved Domains (4) summary
    COG5207
    Location:169637
    UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]
    cd02665
    Location:170656
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd14354
    Location:1560
    UBA_UBP25; UBA domain found in ubiquitin carboxyl-terminal hydrolase 25 (UBP25) and similar proteins
    cd20486
    Location:8471127
    USP25_C; carboxyl-terminal domain of ubiquitin-specific protease 25 (USP25)
  3. XM_006523057.1XP_006523120.1  ubiquitin carboxyl-terminal hydrolase 25 isoform X3

    Conserved Domains (3) summary
    PHA03369
    Location:91218
    PHA03369; capsid maturational protease; Provisional
    cd02665
    Location:1338
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd20486
    Location:529809
    USP25_C; carboxyl-terminal domain of ubiquitin-specific protease 25 (USP25)