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USP25 ubiquitin specific peptidase 25 [ Homo sapiens (human) ]

Gene ID: 29761, updated on 22-Oct-2020

Summary

Official Symbol
USP25provided by HGNC
Official Full Name
ubiquitin specific peptidase 25provided by HGNC
Primary source
HGNC:HGNC:12624
See related
Ensembl:ENSG00000155313 MIM:604736
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
USP21
Summary
Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in testis (RPKM 20.1), endometrium (RPKM 11.0) and 25 other tissues See more
Orthologs

Genomic context

See USP25 in Genome Data Viewer
Location:
21q21.1
Exon count:
31
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (15729947..15880064)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (17102327..17252377)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369302 Neighboring gene RNA, U6 small nuclear 1326, pseudogene Neighboring gene RAD23B pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 8522 Neighboring gene RNA binding protein with multiple splicing-like pseudogene Neighboring gene uncharacterized LOC112268281 Neighboring gene RNA, U6 small nuclear 426, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of panic disorder in the Japanese population.
GeneReviews: Not available
Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
SUMO binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SUMO binding IPI
Inferred from Physical Interaction
more info
PubMed 
cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidase activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
thiol-dependent ubiquitin-specific protease activity TAS
Traceable Author Statement
more info
 
ubiquitin binding NAS
Non-traceable Author Statement
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-like protein-specific protease activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cellular protein modification process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of ERAD pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein K48-linked deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein K63-linked deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
proteolysis TAS
Traceable Author Statement
more info
PubMed 
ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 25
Names
USP on chromosome 21
deubiquitinating enzyme 25
ubiquitin thioesterase 25
ubiquitin thiolesterase 25
ubiquitin-specific processing protease 25
NP_001269970.1
NP_001269971.1
NP_001339489.1
NP_001339490.1
NP_037528.3
XP_005261006.1
XP_011527831.1
XP_011527837.1
XP_016883811.1
XP_016883812.1
XP_016883814.1
XP_016883816.1
XP_024307831.1
XP_024307832.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001283041.3NP_001269970.1  ubiquitin carboxyl-terminal hydrolase 25 isoform USP25m

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (USP25m).
    Source sequence(s)
    AJ010597, AJ010598, BC075792, BM149594, FJ763652
    Consensus CDS
    CCDS63336.1
    UniProtKB/Swiss-Prot
    Q9UHP3
    Related
    ENSP00000383044.2, ENST00000400183.6
    Conserved Domains (3) summary
    cd02665
    Location:170655
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd14354
    Location:1560
    UBA_UBP25; UBA domain found in ubiquitin carboxyl-terminal hydrolase 25 (UBP25) and similar proteins
    pfam00443
    Location:168405
    UCH; Ubiquitin carboxyl-terminal hydrolase
  2. NM_001283042.3NP_001269971.1  ubiquitin carboxyl-terminal hydrolase 25 isoform USP25b

    See identical proteins and their annotated locations for NP_001269971.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (USP25b) that is shorter than isoform a.
    Source sequence(s)
    AF170562, AJ010597, AJ010598, BC075792, BM149594
    Consensus CDS
    CCDS63337.1
    UniProtKB/Swiss-Prot
    Q9UHP3
    Related
    ENSP00000285681.2, ENST00000285681.6
    Conserved Domains (3) summary
    cd02665
    Location:170655
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd14354
    Location:1560
    UBA_UBP25; UBA domain found in ubiquitin carboxyl-terminal hydrolase 25 (UBP25) and similar proteins
    pfam00443
    Location:168405
    UCH; Ubiquitin carboxyl-terminal hydrolase
  3. NM_001352560.2NP_001339489.1  ubiquitin carboxyl-terminal hydrolase 25 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AJ010597, AJ010598, BM149594
    Conserved Domains (1) summary
    cd02665
    Location:37434
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
  4. NM_001352561.2NP_001339490.1  ubiquitin carboxyl-terminal hydrolase 25 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AJ010597, AJ010598, BM149594
    Conserved Domains (1) summary
    cl02553
    Location:163251
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  5. NM_001388299.1NP_001375228.1  ubiquitin carboxyl-terminal hydrolase 25 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AJ010597, AJ010598
  6. NM_001388300.1NP_001375229.1  ubiquitin carboxyl-terminal hydrolase 25 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AJ010597, AJ010598
  7. NM_001388301.1NP_001375230.1  ubiquitin carboxyl-terminal hydrolase 25 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AJ010597, AJ010598
  8. NM_001388302.1NP_001375231.1  ubiquitin carboxyl-terminal hydrolase 25 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AJ010597, AJ010598
  9. NM_013396.6NP_037528.3  ubiquitin carboxyl-terminal hydrolase 25 isoform USP25a

    See identical proteins and their annotated locations for NP_037528.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 3' coding region, compared to variant 1, resulting in an isoform (USP25a) that is shorter than isoform a.
    Source sequence(s)
    AJ010597, AJ010598, BC075792, BM149594
    Consensus CDS
    CCDS33515.1
    UniProtKB/Swiss-Prot
    Q9UHP3
    Related
    ENSP00000285679.6, ENST00000285679.10
    Conserved Domains (3) summary
    cd02665
    Location:170655
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd14354
    Location:1560
    UBA_UBP25; UBA domain found in ubiquitin carboxyl-terminal hydrolase 25 (UBP25) and similar proteins
    cl02553
    Location:168298
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    15729947..15880064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028322.1XP_016883811.1  ubiquitin carboxyl-terminal hydrolase 25 isoform X2

    Conserved Domains (1) summary
    cd02665
    Location:37434
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
  2. XM_011529529.1XP_011527831.1  ubiquitin carboxyl-terminal hydrolase 25 isoform X1

    Conserved Domains (3) summary
    cd02665
    Location:170655
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd14354
    Location:1560
    UBA_UBP25; UBA domain found in ubiquitin carboxyl-terminal hydrolase 25 (UBP25) and similar proteins
    pfam00443
    Location:168405
    UCH; Ubiquitin carboxyl-terminal hydrolase
  3. XM_017028325.1XP_016883814.1  ubiquitin carboxyl-terminal hydrolase 25 isoform X4

  4. XM_011529535.2XP_011527837.1  ubiquitin carboxyl-terminal hydrolase 25 isoform X6

    Conserved Domains (4) summary
    cd02665
    Location:170399
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd14354
    Location:1560
    UBA_UBP25; UBA domain found in ubiquitin carboxyl-terminal hydrolase 25 (UBP25) and similar proteins
    cl02553
    Location:168298
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:168405
    UCH; Ubiquitin carboxyl-terminal hydrolase
  5. XM_024452063.1XP_024307831.1  ubiquitin carboxyl-terminal hydrolase 25 isoform X2

    Conserved Domains (1) summary
    cd02665
    Location:37434
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
  6. XM_024452064.1XP_024307832.1  ubiquitin carboxyl-terminal hydrolase 25 isoform X3

    Conserved Domains (1) summary
    cd02665
    Location:22391
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
  7. XM_017028323.2XP_016883812.1  ubiquitin carboxyl-terminal hydrolase 25 isoform X2

    Conserved Domains (1) summary
    cd02665
    Location:37434
    Peptidase_C19I; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
  8. XM_017028327.1XP_016883816.1  ubiquitin carboxyl-terminal hydrolase 25 isoform X5

    Conserved Domains (1) summary
    cl02553
    Location:163251
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
  9. XM_005260949.4XP_005261006.1  ubiquitin carboxyl-terminal hydrolase 25 isoform X5

    Conserved Domains (1) summary
    cl02553
    Location:163251
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

RNA

  1. XR_002958592.1 RNA Sequence

  2. XR_001754834.1 RNA Sequence

  3. XR_002958593.1 RNA Sequence

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