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    Pla1a phospholipase A1 member A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85311, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Pla1aprovided by RGD
    Official Full Name
    phospholipase A1 member Aprovided by RGD
    Primary source
    RGD:621261
    See related
    Ensembl:ENSRNOG00000057153 AllianceGenome:RGD:621261
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pspla1; Ps-pla1
    Summary
    Predicted to enable phospholipase A1 activity. Predicted to be involved in lipid catabolic process. Predicted to be located in acrosomal membrane. Predicted to be active in extracellular space. Orthologous to human PLA1A (phospholipase A1 member A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 302.9), Heart (RPKM 91.0) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pla1a in Genome Data Viewer
    Location:
    11q21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (75825626..75863296)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (62320112..62357779)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (64882024..64919714)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352341 Neighboring gene ADP-ribosylarginine hydrolase Neighboring gene popeye domain containing 2 Neighboring gene cytochrome c oxidase copper chaperone COX17 Neighboring gene cilia and flagella associated protein 91

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phosphatidylserine-specific phospholipase A1 stimulates histamine release from rat peritoneal mast cells through production of 2-acyl-1-lysophosphatidylserine. Hosono H, et al. J Biol Chem, 2001 Aug 10. PMID 11395520
    2. Serine phospholipid-specific phospholipase A that is secreted from activated platelets. A new member of the lipase family. Sato T, et al. J Biol Chem, 1997 Jan 24. PMID 8999922
    3. Phospholipase B is activated in response to sterol removal and stimulates acrosome exocytosis in murine sperm. Asano A, et al. J Biol Chem, 2013 Sep 27. PMID 23943622, Free PMC Article
    4. Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Abonnenc M, et al. Circ Res, 2013 Oct 25. PMID 24006456
    5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phospholipase A1 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipase A1 activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phospholipase A1 member A
    Names
    phosphatidylserine-specific phospholipase A1
    NP_620237.1
    XP_006248439.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138882.2 → NP_620237.1  phospholipase A1 member A precursor

      See identical proteins and their annotated locations for NP_620237.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      P97535
      UniProtKB/TrEMBL
      A6IR69
      Related
      ENSRNOP00000071860.1, ENSRNOT00000077727.2
      Conserved Domains (1) summary
      pfam00151
      Location:14 → 336
      Lipase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      75825626..75863296
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248377.4 → XP_006248439.1  phospholipase A1 member A isoform X1

      Conserved Domains (2) summary
      cd00707
      Location:49 → 332
      Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
      pfam00151
      Location:14 → 336
      Lipase; Lipase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97535.1 GenPept UniProtKB/Swiss-Prot:P97535

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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