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Pla1a phospholipase A1 member A [ Mus musculus (house mouse) ]

Gene ID: 85031, updated on 27-Nov-2024

Summary

Official Symbol
Pla1aprovided by MGI
Official Full Name
phospholipase A1 member Aprovided by MGI
Primary source
MGI:MGI:1934677
See related
Ensembl:ENSMUSG00000002847 AllianceGenome:MGI:1934677
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pspla1; Ps-pla1
Summary
Enables phospholipase A1 activity. Predicted to be involved in lipid catabolic process. Located in acrosomal membrane. Is expressed in adrenal gland; alimentary system; gland; and liver. Orthologous to human PLA1A (phospholipase A1 member A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver E18 (RPKM 27.9), mammary gland adult (RPKM 23.4) and 13 other tissues See more
Orthologs
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Genomic context

See Pla1a in Genome Data Viewer
Location:
16 B3; 16 26.83 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (38214245..38253553, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (38396117..38433191, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9163 Neighboring gene cytochrome c oxidase assembly protein 17, copper chaperone Neighboring gene popeye domain containing 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:38400095-38400248 Neighboring gene STARR-positive B cell enhancer ABC_E8634 Neighboring gene STARR-seq mESC enhancer starr_40819 Neighboring gene STARR-seq mESC enhancer starr_40820 Neighboring gene predicted gene, 36333 Neighboring gene STARR-seq mESC enhancer starr_40821 Neighboring gene ADP-ribosylarginine hydrolase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phospholipase A1 activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phospholipase A1 activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in acrosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
phospholipase A1 member A
Names
phosphatidylserine-specific phospholipase A1
NP_598863.3
XP_006522834.1
XP_006522835.1
XP_006522837.1
XP_036016082.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134102.4NP_598863.3  phospholipase A1 member A precursor

    See identical proteins and their annotated locations for NP_598863.3

    Status: VALIDATED

    Source sequence(s)
    AF063498, BC030670
    Consensus CDS
    CCDS28166.1
    UniProtKB/Swiss-Prot
    E9QN71, Q8VI78, Q99J51
    Related
    ENSMUSP00000002926.7, ENSMUST00000002926.8
    Conserved Domains (1) summary
    pfam00151
    Location:14336
    Lipase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    38214245..38253553 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160189.1XP_036016082.1  phospholipase A1 member A isoform X2

    Conserved Domains (1) summary
    pfam00151
    Location:14336
    Lipase
  2. XM_006522771.1XP_006522834.1  phospholipase A1 member A isoform X1

    See identical proteins and their annotated locations for XP_006522834.1

    UniProtKB/Swiss-Prot
    E9QN71, Q8VI78, Q99J51
    Conserved Domains (1) summary
    pfam00151
    Location:14336
    Lipase
  3. XM_006522772.1XP_006522835.1  phospholipase A1 member A isoform X1

    See identical proteins and their annotated locations for XP_006522835.1

    UniProtKB/Swiss-Prot
    E9QN71, Q8VI78, Q99J51
    Conserved Domains (1) summary
    pfam00151
    Location:14336
    Lipase
  4. XM_006522774.2XP_006522837.1  phospholipase A1 member A isoform X3

    Conserved Domains (1) summary
    pfam00151
    Location:14336
    Lipase