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PLA1A phospholipase A1 member A [ Homo sapiens (human) ]

Gene ID: 51365, updated on 20-Apr-2020

Summary

Official Symbol
PLA1Aprovided by HGNC
Official Full Name
phospholipase A1 member Aprovided by HGNC
Primary source
HGNC:HGNC:17661
See related
Ensembl:ENSG00000144837 MIM:607460
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSPLA1; PS-PLA1
Summary
The protein encoded by this gene is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
Expression
Broad expression in liver (RPKM 8.5), lymph node (RPKM 6.1) and 17 other tissues See more
Orthologs

Genomic context

See PLA1A in Genome Data Viewer
Location:
3q13.33
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (119597848..119629811)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (119316695..119348658)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986118 Neighboring gene ADP-ribosylarginine hydrolase Neighboring gene uncharacterized LOC105374062 Neighboring gene ribosomal protein L10 pseudogene 7 Neighboring gene popeye domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of phospholipase A1 member A (PLA1A) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of phospholipase A1 member A (PLA1A) in primary human brain microvascular endothelial cells PubMed
tat HIV-1 Tat upregulates phospholipase A1 member A (PLA1A) expression in Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylserine 1-acylhydrolase activity TAS
Traceable Author Statement
more info
 
phospholipase A1 activity IEA
Inferred from Electronic Annotation
more info
 
phospholipase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
phosphatidylserine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylserine metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
acrosomal membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
phospholipase A1 member A
Names
phosphatidylserine-specific phospholipase A1alpha
NP_001193889.1
NP_001193890.1
NP_001280154.1
NP_056984.1
XP_016862061.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029696.1 RefSeqGene

    Range
    5011..36937
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001206960.1NP_001193889.1  phospholipase A1 member A isoform 2 precursor

    See identical proteins and their annotated locations for NP_001193889.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC035347, BC047703, DB189568
    Consensus CDS
    CCDS56268.1
    UniProtKB/Swiss-Prot
    Q53H76
    Related
    ENSP00000417326.1, ENST00000495992.5
    Conserved Domains (1) summary
    pfam00151
    Location:16320
    Lipase; Lipase
  2. NM_001206961.1NP_001193890.1  phospholipase A1 member A isoform 3

    See identical proteins and their annotated locations for NP_001193890.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate coding exon compared to variant 1. The resulting isoform (3) uses a downstream AUG start site and is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK301880, BC035347, DB189568
    Consensus CDS
    CCDS56269.1
    UniProtKB/Swiss-Prot
    Q53H76
    Related
    ENSP00000420625.1, ENST00000488919.5
    Conserved Domains (1) summary
    cl21494
    Location:2159
    Abhydrolase; alpha/beta hydrolases
  3. NM_001293225.1NP_001280154.1  phospholipase A1 member A isoform 4

    See identical proteins and their annotated locations for NP_001280154.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded protein (isoform 4) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    BC035347, BX647516
    Consensus CDS
    CCDS77795.1
    UniProtKB/TrEMBL
    G5E9W0
    Related
    ENSP00000418793.1, ENST00000494440.5
    Conserved Domains (2) summary
    cd00707
    Location:33316
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    pfam00151
    Location:10320
    Lipase; Lipase
  4. NM_015900.4NP_056984.1  phospholipase A1 member A isoform 1 precursor

    See identical proteins and their annotated locations for NP_056984.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK313519, BC035347
    Consensus CDS
    CCDS2991.1
    UniProtKB/Swiss-Prot
    Q53H76
    Related
    ENSP00000273371.4, ENST00000273371.9
    Conserved Domains (2) summary
    cd00707
    Location:49332
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    pfam00151
    Location:16336
    Lipase; Lipase

RNA

  1. NR_120610.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate 3' splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF035269, BC035347, DB189568

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    119597848..119629811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006572.1XP_016862061.1  phospholipase A1 member A isoform X1

    UniProtKB/Swiss-Prot
    Q53H76
    Conserved Domains (1) summary
    cl21494
    Location:2159
    Abhydrolase; alpha/beta hydrolases
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