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    bag5 BCL2 associated athanogene 5 [ Danio rerio (zebrafish) ]

    Gene ID: 569580, updated on 27-Mar-2024

    Summary

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    Official Symbol
    bag5provided by ZNC
    Official Full Name
    BCL2 associated athanogene 5provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050913-58
    See related
    Ensembl:ENSDARG00000017316 AllianceGenome:ZFIN:ZDB-GENE-050913-58
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:114117
    Summary
    Predicted to enable adenyl-nucleotide exchange factor activity and chaperone binding activity. Predicted to be involved in negative regulation of protein ubiquitination; protein stabilization; and regulation of inclusion body assembly. Predicted to be active in cytosol; membrane; and nucleus. Orthologous to human BAG5 (BAG cochaperone 5). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See bag5 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (15762270..15799266, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (15631010..15668250, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene creatine kinase, brain a Neighboring gene tRNA methyltransferase 61A Neighboring gene cytochrome c oxidase assembly factor 8 Neighboring gene kinesin light chain 1a Neighboring gene si:ch211-57f7.7 Neighboring gene uncharacterized LOC101883107

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Thyme SB, et al. Cell, 2019 Apr 4. PMID 30929901, Free PMC Article
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114117

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables adenyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of inclusion body assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    BAG family molecular chaperone regulator 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034183.1 → NP_001029355.1  BAG family molecular chaperone regulator 5

      See identical proteins and their annotated locations for NP_001029355.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097176
      UniProtKB/TrEMBL
      Q4V8W0
      Related
      ENSDARP00000025044.7, ENSDART00000010286.9
      Conserved Domains (2) summary
      smart00264
      Location:390 → 465
      BAG; BAG domains, present in regulator of Hsp70 proteins
      cl02539
      Location:334 → 373
      BAG; BAG domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      15762270..15799266 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005156686.4 → XP_005156743.2  BAG family molecular chaperone regulator 5 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B305, F1QGM6
      Related
      ENSDARP00000111840.1, ENSDART00000124688.3
      Conserved Domains (3) summary
      smart00264
      Location:430 → 505
      BAG; BAG domains, present in regulator of Hsp70 proteins
      pfam02179
      Location:374 → 413
      BAG; BAG domain
      cl02539
      Location:73 → 150
      BAG; BAG domain

    2. XM_021480648.1 → XP_021336323.1  BAG family molecular chaperone regulator 5 isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q9W2, B8A5N0
      Related
      ENSDARP00000112636.1, ENSDART00000145914.3
      Conserved Domains (3) summary
      smart00264
      Location:413 → 488
      BAG; BAG domains, present in regulator of Hsp70 proteins
      pfam02179
      Location:357 → 396
      BAG; BAG domain
      cl02539
      Location:56 → 133
      BAG; BAG domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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