Format

Send to:

Choose Destination

BAG5 BCL2 associated athanogene 5 [ Homo sapiens (human) ]

Gene ID: 9529, updated on 5-Aug-2018

Summary

Official Symbol
BAG5provided by HGNC
Official Full Name
BCL2 associated athanogene 5provided by HGNC
Primary source
HGNC:HGNC:941
See related
Ensembl:ENSG00000166170 MIM:603885; Vega:OTTHUMG00000171763
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAG-5
Summary
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 41.2), thyroid (RPKM 15.2) and 24 other tissues See more
Orthologs

Genomic context

See BAG5 in Genome Data Viewer
Location:
14q32.33
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (103556544..103562814, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (104022881..104029151, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase 61A Neighboring gene RNA, U7 small nuclear 160 pseudogene Neighboring gene apoptogenic 1, mitochondrial Neighboring gene RNA, U4 small nuclear 68, pseudogene Neighboring gene uncharacterized LOC105370688

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Cellular response to heat stress, organism-specific biosystem (from REACTOME)
    Cellular response to heat stress, organism-specific biosystemIn response to exposure to elevated temperature and certain other proteotoxic stimuli (e.g., hypoxia, free radicals) cells activate a number of cytoprotective mechanisms known collectively as "heat s...
  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
  • Regulation of HSF1-mediated heat shock response, organism-specific biosystem (from REACTOME)
    Regulation of HSF1-mediated heat shock response, organism-specific biosystemThe ability of HSF1 to respond to cellular stresses is under negative regulation by chaperones, modulation of nucleocytoplasmic shuttling, post-translational modifications and transition from monomer...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
adenyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein refolding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
neuron death ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein folding TAS
Traceable Author Statement
more info
PubMed 
protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cellular response to heat TAS
Traceable Author Statement
more info
 
regulation of inclusion body assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
inclusion body IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleus HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
BAG family molecular chaperone regulator 5
Names
bcl-2-associated athanogene 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001015048.2NP_001015048.1  BAG family molecular chaperone regulator 5 isoform b

    See identical proteins and their annotated locations for NP_001015048.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AL139300, BF941752, CA424706
    Consensus CDS
    CCDS9982.1
    UniProtKB/Swiss-Prot
    Q9UL15
    UniProtKB/TrEMBL
    A0A024R6M6
    Related
    ENSP00000299204.4, ENST00000299204.4
    Conserved Domains (1) summary
    smart00264
    Location:365442
    BAG; BAG domains, present in regulator of Hsp70 proteins
  2. NM_001015049.2NP_001015049.1  BAG family molecular chaperone regulator 5 isoform a

    See identical proteins and their annotated locations for NP_001015049.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AL139300, BC044216, CA424706, DB022769, DB457402
    Consensus CDS
    CCDS41995.1
    UniProtKB/Swiss-Prot
    Q9UL15
    Related
    ENSP00000338814.4, OTTHUMP00000246787, ENST00000337322.4, OTTHUMT00000414991
    Conserved Domains (1) summary
    smart00264
    Location:406483
    BAG; BAG domains, present in regulator of Hsp70 proteins
  3. NM_004873.3NP_004864.1  BAG family molecular chaperone regulator 5 isoform b

    See identical proteins and their annotated locations for NP_004864.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AF095195, AL139300, CA424706, DB022769
    Consensus CDS
    CCDS9982.1
    UniProtKB/Swiss-Prot
    Q9UL15
    UniProtKB/TrEMBL
    A0A024R6M6
    Related
    ENSP00000391713.2, OTTHUMP00000246786, ENST00000445922.2, OTTHUMT00000414990
    Conserved Domains (1) summary
    smart00264
    Location:365442
    BAG; BAG domains, present in regulator of Hsp70 proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    103556544..103562814 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center