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Bag5 BCL2-associated athanogene 5 [ Mus musculus (house mouse) ]

Gene ID: 70369, updated on 3-Jun-2024

Summary

Official Symbol
Bag5provided by MGI
Official Full Name
BCL2-associated athanogene 5provided by MGI
Primary source
MGI:MGI:1917619
See related
Ensembl:ENSMUSG00000049792 AllianceGenome:MGI:1917619
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bag-5; 1600025G07Rik; 4930405J06Rik
Summary
Predicted to enable adenyl-nucleotide exchange factor activity; chaperone binding activity; and enzyme binding activity. Predicted to be involved in several processes, including negative regulation of cellular protein metabolic process; negative regulation of protein refolding; and protein stabilization. Predicted to be located in inclusion body; mitochondrion; and perinuclear region of cytoplasm. Predicted to be active in cytosol; membrane; and nucleus. Orthologous to human BAG5 (BAG cochaperone 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 180.4), CNS E11.5 (RPKM 14.4) and 6 other tissues See more
Orthologs
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Genomic context

See Bag5 in Genome Data Viewer
Location:
12 F1; 12 61.11 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (111675922..111679690, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (111709488..111713256, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1606 Neighboring gene predicted gene, 51961 Neighboring gene predicted gene, 36635 Neighboring gene cytochrome c oxidase assembly factor 8 Neighboring gene STARR-seq mESC enhancer starr_33333 Neighboring gene STARR-positive B cell enhancer ABC_E7188 Neighboring gene kinesin light chain 1 Neighboring gene STARR-positive B cell enhancer ABC_E209 Neighboring gene X-ray repair complementing defective repair in Chinese hamster cells 3 Neighboring gene zinc finger, FYVE domain containing 21

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables adenyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-folding chaperone binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein refolding ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein refolding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in protein stabilization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of inclusion body assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of inclusion body assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of inclusion body assembly ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in inclusion body ISO
Inferred from Sequence Orthology
more info
 
located_in inclusion body ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
part_of junctional membrane complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
BAG family molecular chaperone regulator 5
Names
BAG-family molecular chaperone regulator-5 (BAG-5)
bcl-2-associated athanogene 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324480.1NP_001311409.1  BAG family molecular chaperone regulator 5

    Status: VALIDATED

    Source sequence(s)
    AC152065, AK160246, BC055762, CJ046703
    Consensus CDS
    CCDS26185.1
    UniProtKB/Swiss-Prot
    Q3TVA8, Q8CI32, Q8K175, Q9DAU0
    Related
    ENSMUSP00000125183.2, ENSMUST00000160576.2
    Conserved Domains (1) summary
    smart00264
    Location:986
    BAG; BAG domains, present in regulator of Hsp70 proteins
  2. NM_001324481.1NP_001311410.1  BAG family molecular chaperone regulator 5

    Status: VALIDATED

    Source sequence(s)
    AK160246, BC055762, CJ046703
    Consensus CDS
    CCDS26185.1
    UniProtKB/Swiss-Prot
    Q3TVA8, Q8CI32, Q8K175, Q9DAU0
    Conserved Domains (1) summary
    smart00264
    Location:986
    BAG; BAG domains, present in regulator of Hsp70 proteins
  3. NM_001324482.1NP_001311411.1  BAG family molecular chaperone regulator 5

    Status: VALIDATED

    Source sequence(s)
    AC152065, AK160246, BC055762, CJ047026
    Consensus CDS
    CCDS26185.1
    UniProtKB/Swiss-Prot
    Q3TVA8, Q8CI32, Q8K175, Q9DAU0
    Conserved Domains (1) summary
    smart00264
    Location:986
    BAG; BAG domains, present in regulator of Hsp70 proteins
  4. NM_027404.2NP_081680.1  BAG family molecular chaperone regulator 5

    See identical proteins and their annotated locations for NP_081680.1

    Status: VALIDATED

    Source sequence(s)
    AC152065, BC055762, CX243791
    Consensus CDS
    CCDS26185.1
    UniProtKB/Swiss-Prot
    Q3TVA8, Q8CI32, Q8K175, Q9DAU0
    Related
    ENSMUSP00000051049.7, ENSMUST00000054636.7
    Conserved Domains (1) summary
    smart00264
    Location:986
    BAG; BAG domains, present in regulator of Hsp70 proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    111675922..111679690 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516217.5XP_006516280.1  BAG family molecular chaperone regulator 5 isoform X1

    See identical proteins and their annotated locations for XP_006516280.1

    UniProtKB/Swiss-Prot
    Q3TVA8, Q8CI32, Q8K175, Q9DAU0
    Conserved Domains (1) summary
    smart00264
    Location:986
    BAG; BAG domains, present in regulator of Hsp70 proteins