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    EPHA10 EPH receptor A10 [ Homo sapiens (human) ]

    Gene ID: 284656, updated on 11-Apr-2024

    Summary

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    Official Symbol
    EPHA10provided by HGNC
    Official Full Name
    EPH receptor A10provided by HGNC
    Primary source
    HGNC:HGNC:19987
    See related
    Ensembl:ENSG00000183317 MIM:611123; AllianceGenome:HGNC:19987
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DFNA88
    Summary
    Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells (Aasheim et al., 2005 [PubMed 15777695]). See MIM 179610 for additional background on Eph receptors and ephrins.[supplied by OMIM, Mar 2008]
    Expression
    Biased expression in testis (RPKM 7.0), colon (RPKM 2.9) and 7 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    1p34.3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (37713880..37765120, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (37578599..37629649, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (38181648..38230792, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 773 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 774 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 775 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:38156929-38157439 Neighboring gene AFG2 interacting ribosome maturation factor Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:38157440-38157949 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:38157950-38158460 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:38158461-38158969 Neighboring gene cell division cycle associated 8 Neighboring gene MPRA-validated peak183 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38191191-38191692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38191693-38192192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38192280-38192780 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38192781-38193281 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:38201025-38201524 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 676 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 677 Neighboring gene uncharacterized LOC105378650 Neighboring gene actinin alpha 4 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A non-coding variant in 5' untranslated region drove up-regulation of pseudo-kinase EPHA10 and caused non-syndromic hearing loss in humans. Huang S, et al. Hum Mol Genet, 2023 Feb 19. PMID 36048850
    2. EphA10 drives tumor progression and immune evasion by regulating the MAPK/ERK cascade in lung adenocarcinoma. Zhao W, et al. Int Immunopharmacol, 2022 Sep. PMID 35839564
    3. Isoform expression patterns of EPHA10 protein mediate breast cancer progression by regulating the E-Cadherin and β-catenin complex. Li Y, et al. Oncotarget, 2017 May 2. PMID 28427223, Free PMC Article
    4. Ephrin receptor A10 is a promising drug target potentially useful for breast cancers including triple negative breast cancers. Nagano K, et al. J Control Release, 2014 Sep 10. PMID 24946238
    5. Eph receptor A10 has a potential as a target for a prostate cancer therapy. Nagano K, et al. Biochem Biophys Res Commun, 2014 Jul 18. PMID 24924629

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A non-coding variant in 5' untranslated region drove up-regulation of pseudo-kinase EPHA10 and caused non-syndromic hearing loss in humans.
      Title: A non-coding variant in 5' untranslated region drove up-regulation of pseudo-kinase EPHA10 and caused non-syndromic hearing loss in humans.
    2. EphA10 drives tumor progression and immune evasion by regulating the MAPK/ERK cascade in lung adenocarcinoma.
      Title: EphA10 drives tumor progression and immune evasion by regulating the MAPK/ERK cascade in lung adenocarcinoma.
    3. Coexpression of EphA10 and Gli3 promotes breast cancer cell proliferation, invasion and migration.
      Title: Coexpression of EphA10 and Gli3 promotes breast cancer cell proliferation, invasion and migration.
    4. Ephrin A4-ephrin receptor A10 signaling promotes cell migration and spheroid formation by upregulating NANOG expression in oral squamous cell carcinoma cells.
      Title: Ephrin A4-ephrin receptor A10 signaling promotes cell migration and spheroid formation by upregulating NANOG expression in oral squamous cell carcinoma cells.
    5. Cataloguing the dead: breathing new life into pseudokinase research.
      Title: Cataloguing the dead: breathing new life into pseudokinase research.
    6. we defined the novel interaction via expression patterns of EphA10s and EphA10 that promote malignant transformation of breast cancer, and demonstrated the potential benefit in clinical usage.
      Title: Isoform expression patterns of EPHA10 protein mediate breast cancer progression by regulating the E-Cadherin and β-catenin complex.
    7. We have demonstrated the physical association and cellular co-localization of EPHA7 and EPHA10 in breast carcinoma cells. The nuclear co-localization of these two receptors in invasive MDA-MB-231 cells suggests their involvement in transcriptional activation of genes involved in invasiveness.
      Title: EPHA7 and EPHA10 Physically Interact and Differentially Co-localize in Normal Breast and Breast Carcinoma Cell Lines, and the Co-localization Pattern Is Altered in EPHB6-expressing MDA-MB-231 Cells.
    8. Ephrin receptor A10 is a promising drug target potentially useful for breast cancers including triple negative breast cancers
      Title: Ephrin receptor A10 is a promising drug target potentially useful for breast cancers including triple negative breast cancers.
    9. Therefore, the idea was conceived that the overexpression of EphA10 in prostate cancers might have a potential as a target for prostate cancer therapy, and formed the basis for the studies reported here.
      Title: Eph receptor A10 has a potential as a target for a prostate cancer therapy.
    10. EphA10 expression at both the gene and protein level in clinical breast cancer tissues is significantly associated with lymph node metastasis as well as stage progression.
      Title: Expression of Eph receptor A10 is correlated with lymph node metastasis and stage progression in breast cancer patients.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Hearing loss, autosomal dominant 88
    MedGen: C5830355 OMIM: 620283 GeneReviews: Not available
    		not available

    EBI GWAS Catalog

    Description
    A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
    EBI GWAS Catalog
    Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ16103, FLJ33655, MGC43817

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane-ephrin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in ephrin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    ephrin type-A receptor 10
    Names
    EphA10s protein
    NP_001092909.1
    NP_775912.2
    XP_016856569.1
    XP_016856570.1
    XP_047274347.1
    XP_047274359.1
    XP_054192110.1
    XP_054192111.1
    XP_054192112.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099439.2 → NP_001092909.1  ephrin type-A receptor 10 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001092909.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longer transcript and encodes the longer isoform (3).
      Source sequence(s)
      AC104336, AJ872185, BC039363, BC041360
      Consensus CDS
      CCDS41305.1
      UniProtKB/Swiss-Prot
      A4FU89, J3KPB5, Q5JZY3, Q6NW42
      UniProtKB/TrEMBL
      J3KQG3
      Related
      ENSP00000362139.4, ENST00000373048.9
      Conserved Domains (8) summary
      cd05064
      Location:639 → 904
      PTKc_EphR_A10; Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A10
      smart00454
      Location:932 → 997
      SAM; Sterile alpha motif
      cd00063
      Location:451 → 531
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:339 → 431
      fn3; Fibronectin type III domain
      pfam07714
      Location:645 → 900
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:573 → 640
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl02704
      Location:35 → 210
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
      cl15755
      Location:929 → 998
      SAM_superfamily; SAM (Sterile alpha motif )

    2. NM_173641.3 → NP_775912.2  ephrin type-A receptor 10 isoform 2 precursor

      See identical proteins and their annotated locations for NP_775912.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains only the first three exons and some of the third intron compared to variant 3. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 3.
      Source sequence(s)
      AJ781169, AK090974, BC067734
      Consensus CDS
      CCDS425.1
      UniProtKB/TrEMBL
      Q8N289
      Related
      ENSP00000316395.6, ENST00000319637.6
      Conserved Domains (1) summary
      cl02704
      Location:35 → 210
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      37713880..37765120 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017001080.1 → XP_016856569.1  ephrin type-A receptor 10 isoform X1

      UniProtKB/TrEMBL
      Q6ZNH1
      Related
      ENST00000446149.6

    2. XM_047418403.1 → XP_047274359.1  ephrin type-A receptor 10 isoform X4

      Related
      ENSP00000431389.1, ENST00000534097.5

    3. XM_017001081.2 → XP_016856570.1  ephrin type-A receptor 10 isoform X3

    4. XM_047418391.1 → XP_047274347.1  ephrin type-A receptor 10 isoform X2

    RNA

    1. XR_946610.2 RNA Sequence

    2. XR_001737124.2 RNA Sequence

    3. XR_946613.3 RNA Sequence

    4. XR_001737123.2 RNA Sequence

    5. XR_001737125.3 RNA Sequence

    6. XR_001737127.1 RNA Sequence

    7. XR_001737126.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      37578599..37629649 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336135.1 → XP_054192110.1  ephrin type-A receptor 10 isoform X1

    2. XM_054336137.1 → XP_054192112.1  ephrin type-A receptor 10 isoform X4

    3. XM_054336136.1 → XP_054192111.1  ephrin type-A receptor 10 isoform X3

    RNA

    1. XR_008486004.1 RNA Sequence

    2. XR_008486003.1 RNA Sequence

    3. XR_008486001.1 RNA Sequence

    4. XR_008486002.1 RNA Sequence

    5. XR_008486005.1 RNA Sequence

    6. XR_008486007.1 RNA Sequence

    7. XR_008486006.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001004338.2: Suppressed sequence

      Description
      NM_001004338.2: This RefSeq was permanently suppressed because the encoded protein is partial, and it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5JZY3.2 GenPept UniProtKB/Swiss-Prot:Q5JZY3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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