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    ZNF667 zinc finger protein 667 [ Homo sapiens (human) ]

    Gene ID: 63934, updated on 5-Mar-2024

    Summary

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    Official Symbol
    ZNF667provided by HGNC
    Official Full Name
    zinc finger protein 667provided by HGNC
    Primary source
    HGNC:HGNC:28854
    See related
    Ensembl:ENSG00000198046 MIM:611024; AllianceGenome:HGNC:28854
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MIPU1
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in brain (RPKM 3.0), thyroid (RPKM 2.8) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    19q13.43
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (56439329..56478093, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (59533762..59572529, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (56950698..56988714, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF582 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15119 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11069 Neighboring gene zinc finger protein 583 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:56968363-56969562 Neighboring gene ZNF667 antisense RNA 1 (head to head) Neighboring gene uncharacterized LOC105372471 Neighboring gene uncharacterized LOC124904776

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Effect of MIPU1 gene interference on biological behavior of U251 cell line. Liu M, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2020 Feb 28. PMID 32386033
    2. Aberrant methylation and downregulation of ZNF667-AS1 and ZNF667 promote the malignant progression of laryngeal squamous cell carcinoma. Meng W, et al. J Biomed Sci, 2019 Jan 26. PMID 30684967, Free PMC Article
    3. ZNF667 Serves as a Putative Oncogene in Human Hepatocellular Carcinoma. Cheng K, et al. Cell Physiol Biochem, 2017. PMID 28472789
    4. ZNF667 facilitates angiogenesis after myocardial ischemia through transcriptional regulation of VASH1 and Wnt signaling pathway. Wang W, et al. Int J Mol Med, 2022 Oct. PMID 36043524, Free PMC Article
    5. MicroRNA-23b-3p participates in steroid-induced osteonecrosis of the femoral head by suppressing ZNF667 expression. Liu Y, et al. Steroids, 2020 Nov. PMID 32730776

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF667 facilitates angiogenesis after myocardial ischemia through transcriptional regulation of VASH1 and Wnt signaling pathway.
      Title: ZNF667 facilitates angiogenesis after myocardial ischemia through transcriptional regulation of VASH1 and Wnt signaling pathway.
    2. MicroRNA-23b-3p participates in steroid-induced osteonecrosis of the femoral head by suppressing ZNF667 expression.
      Title: MicroRNA-23b-3p participates in steroid-induced osteonecrosis of the femoral head by suppressing ZNF667 expression.
    3. Aberrant hypermethylation-mediated downregulation of antisense lncRNA ZNF667-AS1 and its sense gene ZNF667 correlate with progression and prognosis of esophageal squamous cell carcinoma.
      Title: Aberrant hypermethylation-mediated downregulation of antisense lncRNA ZNF667-AS1 and its sense gene ZNF667 correlate with progression and prognosis of esophageal squamous cell carcinoma.
    4. Down-regulation of MIPU1 can promote apoptosis while inhibit the proliferation, invasion, and migration of U251 cells
      Title: Effect of MIPU1 gene interference on biological behavior of U251 cell line.
    5. ZNF667-AS1 and ZNF667 are both down-regulated by hypermethylation, and they serve as tumor suppressor genes in LSCC. ZNF667-AS1 regulates the expression of ZNF667 in cis.
      Title: Aberrant methylation and downregulation of ZNF667-AS1 and ZNF667 promote the malignant progression of laryngeal squamous cell carcinoma.
    6. ZNF667 promote the cell proliferation, invasion and migration mainly via interference expression of Bcl-2 and BAX.
      Title: ZNF667 Serves as a Putative Oncogene in Human Hepatocellular Carcinoma.
    7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ14011, FLJ45518, DKFZp686O111

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 667
    Names
    myocardial ischemic preconditioning upregulated 1 ortholog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321355.2 → NP_001308284.1  zinc finger protein 667 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC006116, AC013256, AC098795
      UniProtKB/TrEMBL
      Q5CZB4
      Conserved Domains (3) summary
      COG5048
      Location:84 → 544
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:444 → 464
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:456 → 481
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001321356.2 → NP_001308285.1  zinc finger protein 667 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC006116, AC013256, AC098795
      Consensus CDS
      CCDS12944.1
      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
      Related
      ENSP00000439402.1, ENST00000504904.8
      Conserved Domains (3) summary
      smart00349
      Location:15 → 74
      KRAB; krueppel associated box
      COG5048
      Location:141 → 601
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:501 → 521
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_022103.4 → NP_071386.3  zinc finger protein 667 isoform 1

      See identical proteins and their annotated locations for NP_071386.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the functional protein.
      Source sequence(s)
      AC006116, AC013256, AC098795
      Consensus CDS
      CCDS12944.1
      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
      Related
      ENSP00000292069.5, ENST00000292069.10
      Conserved Domains (3) summary
      smart00349
      Location:15 → 74
      KRAB; krueppel associated box
      COG5048
      Location:141 → 601
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:501 → 521
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      56439329..56478093 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451637.2 → XP_024307405.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
      Conserved Domains (3) summary
      smart00349
      Location:15 → 74
      KRAB; krueppel associated box
      COG5048
      Location:141 → 601
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:501 → 521
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_024451642.2 → XP_024307410.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
      Conserved Domains (3) summary
      smart00349
      Location:15 → 74
      KRAB; krueppel associated box
      COG5048
      Location:141 → 601
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:501 → 521
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_047439212.1 → XP_047295168.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807

    4. XM_024451646.2 → XP_024307414.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
      Conserved Domains (3) summary
      smart00349
      Location:15 → 74
      KRAB; krueppel associated box
      COG5048
      Location:141 → 601
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:501 → 521
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_024451647.2 → XP_024307415.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
      Conserved Domains (3) summary
      smart00349
      Location:15 → 74
      KRAB; krueppel associated box
      COG5048
      Location:141 → 601
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:501 → 521
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. XM_024451644.2 → XP_024307412.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
      Conserved Domains (3) summary
      smart00349
      Location:15 → 74
      KRAB; krueppel associated box
      COG5048
      Location:141 → 601
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:501 → 521
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. XM_024451643.2 → XP_024307411.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
      Conserved Domains (3) summary
      smart00349
      Location:15 → 74
      KRAB; krueppel associated box
      COG5048
      Location:141 → 601
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:501 → 521
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. XM_024451645.2 → XP_024307413.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
      Conserved Domains (3) summary
      smart00349
      Location:15 → 74
      KRAB; krueppel associated box
      COG5048
      Location:141 → 601
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:501 → 521
      ZF_C2H2; C2H2 Zn finger [structural motif]

    9. XM_011527208.3 → XP_011525510.1  zinc finger protein 667 isoform X1

      See identical proteins and their annotated locations for XP_011525510.1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
      Conserved Domains (3) summary
      smart00349
      Location:15 → 74
      KRAB; krueppel associated box
      COG5048
      Location:141 → 601
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:501 → 521
      ZF_C2H2; C2H2 Zn finger [structural motif]

    10. XM_047439211.1 → XP_047295167.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807

    11. XM_047439208.1 → XP_047295164.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807

    12. XM_024451641.2 → XP_024307409.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
      Conserved Domains (3) summary
      smart00349
      Location:15 → 74
      KRAB; krueppel associated box
      COG5048
      Location:141 → 601
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:501 → 521
      ZF_C2H2; C2H2 Zn finger [structural motif]

    13. XM_024451640.2 → XP_024307408.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
      Conserved Domains (3) summary
      smart00349
      Location:15 → 74
      KRAB; krueppel associated box
      COG5048
      Location:141 → 601
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:501 → 521
      ZF_C2H2; C2H2 Zn finger [structural motif]

    14. XM_047439209.1 → XP_047295165.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807

    15. XM_047439210.1 → XP_047295166.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807

    16. XM_047439207.1 → XP_047295163.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807

    17. XM_024451638.2 → XP_024307406.1  zinc finger protein 667 isoform X1

      UniProtKB/Swiss-Prot
      B2RMS6, B9EK36, Q5HYK9, Q6B093, Q9H807
      Conserved Domains (3) summary
      smart00349
      Location:15 → 74
      KRAB; krueppel associated box
      COG5048
      Location:141 → 601
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:501 → 521
      ZF_C2H2; C2H2 Zn finger [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      59533762..59572529 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321728.1 → XP_054177703.1  zinc finger protein 667 isoform X1

    2. XM_054321714.1 → XP_054177689.1  zinc finger protein 667 isoform X1

    3. XM_054321722.1 → XP_054177697.1  zinc finger protein 667 isoform X1

    4. XM_054321726.1 → XP_054177701.1  zinc finger protein 667 isoform X1

    5. XM_054321729.1 → XP_054177704.1  zinc finger protein 667 isoform X1

    6. XM_054321725.1 → XP_054177700.1  zinc finger protein 667 isoform X1

    7. XM_054321720.1 → XP_054177695.1  zinc finger protein 667 isoform X1

    8. XM_054321715.1 → XP_054177690.1  zinc finger protein 667 isoform X1

    9. XM_054321721.1 → XP_054177696.1  zinc finger protein 667 isoform X1

    10. XM_054321717.1 → XP_054177692.1  zinc finger protein 667 isoform X1

    11. XM_054321730.1 → XP_054177705.1  zinc finger protein 667 isoform X1

    12. XM_054321719.1 → XP_054177694.1  zinc finger protein 667 isoform X1

    13. XM_054321727.1 → XP_054177702.1  zinc finger protein 667 isoform X1

    14. XM_054321716.1 → XP_054177691.1  zinc finger protein 667 isoform X1

    15. XM_054321718.1 → XP_054177693.1  zinc finger protein 667 isoform X1

    16. XM_054321723.1 → XP_054177698.1  zinc finger protein 667 isoform X1

    17. XM_054321724.1 → XP_054177699.1  zinc finger protein 667 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5HYK9.2 GenPept UniProtKB/Swiss-Prot:Q5HYK9

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