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RAB11FIP1 RAB11 family interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 80223, updated on 8-May-2016
Official Symbol
RAB11FIP1provided by HGNC
Official Full Name
RAB11 family interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:30265
See related
Ensembl:ENSG00000156675 HPRD:09787; MIM:608737; Vega:OTTHUMG00000164026
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RCP; NOEL1A; rab11-FIP1
Summary
This gene encodes one of the Rab11-family interacting proteins (Rab11-FIPs), which play a role in the Rab-11 mediated recycling of vesicles. The encoded protein may be involved in endocytic sorting, trafficking of proteins including integrin subunits and epidermal growth factor receptor (EGFR), and transport between the recycling endosome and the trans-Golgi network. Alternative splicing results in multiple transcript variants. A pseudogene is described on the X chromosome. [provided by RefSeq, Dec 2013]
Orthologs
Location:
8p11.22
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 8 NC_000008.11 (37858947..37899497, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (37716465..37757015, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379381 Neighboring gene adhesion G protein-coupled receptor A2 Neighboring gene BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit Neighboring gene glutamic-oxaloacetic transaminase 1-like 1 Neighboring gene adrenoceptor beta 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of RAB11-FIP1C by shRNA inhibits HIV-1 infectivity in TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The interaction of RAB11-FIP1C with RAB14 is required for incorporation of HIV-1 Env (gp120/gp41) into virions PubMed
env RAB11-FIP1C is required for HIV-1 Env (gp120/gp41) incorporation into virions, while depletion of RAB11-FIP1C by shRNA diminishes Env incorporation into virions PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 Env relocalizes FIP1C to plasma membrane in a cytoplasmic tail-dependent manner PubMed
env RAB11-FIP1C is required for HIV-1 Env (gp120/gp41) incorporation into virions, while depletion of RAB11-FIP1C by shRNA diminishes Env incorporation into virions PubMed
Envelope transmembrane glycoprotein gp41 env The interaction of RAB11-FIP1C with RAB14 is required for incorporation of HIV-1 Env (gp120/gp41) into virions PubMed
env RAB11-FIP1C is required for HIV-1 Env (gp120/gp41) incorporation into virions, while depletion of RAB11-FIP1C by shRNA diminishes Env incorporation into virions PubMed

Go to the HIV-1, Human Interaction Database

  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ22524, FLJ22622, MGC78448, DKFZp686E2214

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rab GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
negative regulation of adiponectin secretion IDA
Inferred from Direct Assay
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
regulated exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
recycling endosome IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
rab11 family-interacting protein 1
Names
RAB11 coupling protein
RAB11 family interacting protein 1 (class I)
Rab effector protein
Rab-interacting recycling protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002814.2NP_001002814.2  rab11 family-interacting protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001002814.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longer transcript and encodes the longer isoform (3).
    Source sequence(s)
    AC130304, AK026275, AY280968, BC077720
    Consensus CDS
    CCDS34882.1
    UniProtKB/Swiss-Prot
    Q6WKZ4
    Related
    ENSP00000331342, OTTHUMP00000225616, ENST00000330843, OTTHUMT00000376816
    Conserved Domains (2) summary
    cd08682
    Location:20147
    C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
    pfam09457
    Location:12261273
    RBD-FIP; FIP domain
  2. NM_025151.4NP_079427.4  rab11 family-interacting protein 1 isoform 1

    See identical proteins and their annotated locations for NP_079427.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon in the 3' coding region, compared to variant 3. It encodes isoform 1, which is shorter than isoform 3.
    Source sequence(s)
    AC130304, AK026275, BC077720
    Consensus CDS
    CCDS34881.1
    UniProtKB/Swiss-Prot
    Q6WKZ4
    Related
    ENSP00000287263, OTTHUMP00000225615, ENST00000287263, OTTHUMT00000376815
    Conserved Domains (2) summary
    cd08682
    Location:20147
    C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I
    pfam09457
    Location:592639
    RBD-FIP; FIP domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p2 Primary Assembly

    Range
    37858947..37899497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    37917911..37958467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001002233.1: Suppressed sequence

    Description
    NM_001002233.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support an internal transcription initiation site.