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vav2 vav guanine nucleotide exchange factor 2 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 733982, updated on 25-Apr-2024

Summary

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Official Symbol
vav2provided by Xenbase
Official Full Name
vav guanine nucleotide exchange factor 2provided by Xenbase
Primary source
Xenbase:XB-GENE-6067166
See related
Ensembl:ENSXETG00000019578
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Orthologs
human mouse all
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Genomic context

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See vav2 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
31
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 8 NC_030684.2 (8275449..8437508)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) Unplaced Scaffold NW_016683374.1 (254345..417129, complement)

Chromosome 8 - NC_030684.2Genomic Context describing neighboring genes Neighboring gene bromodomain containing 3 Neighboring gene BRD3 opposite strand Neighboring gene nucleolin 1-like Neighboring gene NLR family CARD domain-containing protein 3 Neighboring gene beta-1,3-galactosyltransferase 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
guanine nucleotide exchange factor VAV2
Names
vav 2 guanine nucleotide exchange factor
vav 2 oncogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045691.1 → NP_001039156.1  guanine nucleotide exchange factor VAV2

    See identical proteins and their annotated locations for NP_001039156.1

    Status: PROVISIONAL

    Source sequence(s)
    CR942591
    UniProtKB/TrEMBL
    A0A6I8RFJ2, Q28BX0
    Related
    ENSXETP00000080099.2, ENSXETT00000103455.2
    Conserved Domains (8) summary
    cd10406
    Location:650 → 752
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:779 → 836
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:580 → 639
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    cd01223
    Location:383 → 505
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam00130
    Location:513 → 561
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00169
    Location:400 → 501
    PH; PH domain
    pfam00621
    Location:196 → 369
    RhoGEF; RhoGEF domain
    pfam11971
    Location:19 → 104
    CAMSAP_CH; CAMSAP CH domain

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030684.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    8275449..8437508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_031890516.1 → XP_031746376.1  guanine nucleotide exchange factor VAV2 isoform X1

    UniProtKB/TrEMBL
    A0A8J1IPD9, F6WZD6
    Conserved Domains (7) summary
    cd10406
    Location:699 → 801
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:855 → 912
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:629 → 688
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    cd01223
    Location:388 → 515
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam00621
    Location:201 → 373
    RhoGEF; RhoGEF domain
    cd21263
    Location:3 → 121
    CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
    cd20868
    Location:518 → 575
    C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein

  2. XM_031890518.1 → XP_031746378.1  guanine nucleotide exchange factor VAV2 isoform X3

    UniProtKB/TrEMBL
    A0A8J1ILM5, F6WZD6
    Conserved Domains (7) summary
    cd10406
    Location:694 → 796
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:850 → 907
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:624 → 683
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    cd01223
    Location:388 → 510
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam00621
    Location:201 → 373
    RhoGEF; RhoGEF domain
    cd21263
    Location:3 → 121
    CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
    cd20868
    Location:513 → 570
    C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein

  3. XM_031890520.1 → XP_031746380.1  guanine nucleotide exchange factor VAV2 isoform X5

    UniProtKB/TrEMBL
    A0A8J1INP5, F6WZD6
    Conserved Domains (7) summary
    cd10406
    Location:699 → 801
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:826 → 883
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:629 → 688
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    cd01223
    Location:388 → 515
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam00621
    Location:201 → 373
    RhoGEF; RhoGEF domain
    cd21263
    Location:3 → 121
    CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
    cd20868
    Location:518 → 575
    C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein

  4. XM_031890517.1 → XP_031746377.1  guanine nucleotide exchange factor VAV2 isoform X2

    UniProtKB/TrEMBL
    A0A8J1ILL5, F6WZD6
    Conserved Domains (7) summary
    cd10406
    Location:694 → 796
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:850 → 907
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:624 → 683
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    cd01223
    Location:383 → 510
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam00621
    Location:196 → 368
    RhoGEF; RhoGEF domain
    cd21263
    Location:3 → 121
    CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
    cd20868
    Location:513 → 570
    C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein

  5. XM_031890519.1 → XP_031746379.1  guanine nucleotide exchange factor VAV2 isoform X4

    UniProtKB/TrEMBL
    A0A8J1ILL8, F6WZD6
    Related
    ENSXETP00000042340.4, ENSXETT00000042340.4
    Conserved Domains (7) summary
    cd10406
    Location:689 → 791
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:845 → 902
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:619 → 678
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    cd01223
    Location:383 → 505
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam00621
    Location:196 → 368
    RhoGEF; RhoGEF domain
    cd21263
    Location:3 → 121
    CH_VAV2; calponin homology (CH) domain found in VAV2 protein and similar proteins
    cd20868
    Location:508 → 565
    C1_VAV2; protein kinase C conserved region 1 (C1 domain) found in VAV2 protein

  6. XM_012968560.3 → XP_012824014.1  guanine nucleotide exchange factor VAV2 isoform X6

    UniProtKB/TrEMBL
    A0A6I8RFJ2, A0A8J0SV09
    Related
    ENSXETP00000060789.2, ENSXETT00000062378.3
    Conserved Domains (8) summary
    cd10406
    Location:660 → 762
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:816 → 873
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:590 → 649
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    COG5261
    Location:36 → 179
    IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]
    cd00160
    Location:198 → 373
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01223
    Location:388 → 515
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam11971
    Location:19 → 104
    CAMSAP_CH; CAMSAP CH domain
    pfam00130
    Location:523 → 571
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  7. XM_012968561.3 → XP_012824015.1  guanine nucleotide exchange factor VAV2 isoform X7

    UniProtKB/TrEMBL
    A0A6I8RFJ2, A0A8J0SWD0
    Conserved Domains (8) summary
    cd10406
    Location:660 → 762
    SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins
    cd11977
    Location:787 → 844
    SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein
    cd11980
    Location:590 → 649
    SH3_VAV2_1; First Src homology 3 domain of VAV2 protein
    cd01223
    Location:388 → 515
    PH_Vav; Vav pleckstrin homology (PH) domain
    pfam00130
    Location:523 → 571
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00169
    Location:405 → 511
    PH; PH domain
    pfam00621
    Location:201 → 374
    RhoGEF; RhoGEF domain
    pfam11971
    Location:19 → 104
    CAMSAP_CH; CAMSAP CH domain

RNA

  1. XR_004219473.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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