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CYLD CYLD lysine 63 deubiquitinase [ Macaca mulatta (Rhesus monkey) ]

Gene ID: 695652, updated on 17-Aug-2024

Summary

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Official Symbol
CYLDprovided by VGNC
Official Full Name
CYLD lysine 63 deubiquitinaseprovided by VGNC
Primary source
VGNC:VGNC:71581
See related
Ensembl:ENSMMUG00000012209
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca mulatta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 20
Exon count:
19
Annotation release Status Assembly Chr Location
103 current Mmul_10 (GCF_003339765.1) 20 NC_041773.1 (37840745..37900595)
102 previous assembly Mmul_8.0.1 (GCF_000772875.2) 20 NC_027912.1 (34681852..34741774)

Chromosome 20 - NC_041773.1Genomic Context describing neighboring genes Neighboring gene sorting nexin 20 Neighboring gene nucleotide binding oligomerization domain containing 2 Neighboring gene uncharacterized LOC106995011 Neighboring gene uncharacterized LOC106995003

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables K63-linked deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in necroptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein K63-linked deubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase CYLD

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

  1. NC_041773.1 Reference Mmul_10 Primary Assembly

    Range
    37840745..37900595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015126108.2 → XP_014981594.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

    UniProtKB/TrEMBL
    F6VMX6, H9FQI0
    Conserved Domains (3) summary
    smart01052
    Location:472 → 540
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:593 → 948
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:307 → 471
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured

  2. XM_015126112.2 → XP_014981598.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

    UniProtKB/TrEMBL
    A0A1D5REE5, F6VN20, H9EUD5, H9FQI0
    Related
    ENSMMUP00000016013.4, ENSMMUT00000017099.4
    Conserved Domains (3) summary
    smart01052
    Location:469 → 537
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:590 → 945
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304 → 468
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured

  3. XM_015126111.2 → XP_014981597.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

    UniProtKB/TrEMBL
    F6VMX6, H9FQI0
    Related
    ENSMMUP00000016018.3, ENSMMUT00000017104.4
    Conserved Domains (3) summary
    smart01052
    Location:472 → 540
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:593 → 948
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:307 → 471
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured

  4. XM_015126109.2 → XP_014981595.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X1

    UniProtKB/TrEMBL
    F6VMX6, H9FQI0
    Conserved Domains (3) summary
    smart01052
    Location:472 → 540
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:593 → 948
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:307 → 471
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured

  5. XM_015126113.2 → XP_014981599.1  ubiquitin carboxyl-terminal hydrolase CYLD isoform X2

    UniProtKB/TrEMBL
    A0A1D5REE5, F6VN20, H9EUD5, H9FQI0
    Related
    ENSMMUP00000058688.2, ENSMMUT00000075665.2
    Conserved Domains (3) summary
    smart01052
    Location:469 → 537
    CAP_GLY; Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network
    cd02670
    Location:590 → 945
    Peptidase_C19N; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam16607
    Location:304 → 468
    CYLD_phos_site; Phosphorylation region of CYLD, unstructured
Nucleotide Protein
Heading Accession and Version

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