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Ankra2 ankyrin repeat family A member 2 [ Mus musculus (house mouse) ]

Gene ID: 68558, updated on 13-Apr-2024

Summary

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Official Symbol
Ankra2provided by MGI
Official Full Name
ankyrin repeat family A member 2provided by MGI
Primary source
MGI:MGI:1915808
See related
Ensembl:ENSMUSG00000021661 AllianceGenome:MGI:1915808
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ankra; 1110004M18Rik
Summary
Enables histone deacetylase binding activity. Predicted to be involved in regulation of gene expression and regulation of protein-containing complex assembly. Located in cytoplasm; membrane; and nucleus. Orthologous to human ANKRA2 (ankyrin repeat family A member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 19.9), CNS E14 (RPKM 15.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ankra2 in Genome Data Viewer
Location:
13 D1; 13 51.89 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (98399584..98411262)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (98263076..98274754)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 28 Neighboring gene predicted gene, 34469 Neighboring gene STARR-seq mESC enhancer starr_35415 Neighboring gene STARR-positive B cell enhancer ABC_E5411 Neighboring gene UTP15 small subunit processome component Neighboring gene STARR-seq mESC enhancer starr_35417 Neighboring gene predicted gene 21976 Neighboring gene STARR-seq mESC enhancer starr_35418 Neighboring gene basic transcription factor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Evolutionary conservation and characterization of the bare lymphocyte syndrome transcription factor RFX-B and its paralogue ANKRA2. Long AB, et al. Immunogenetics, 2005 Feb. PMID 15655668
  2. Assignment of ankyrin repeat, family A (RFXANK-like) 2 (ANKRA2) to human chromosome 5q12-->q13 by radiation hybrid mapping and somatic cell hybrid PCR. Rader K, et al. Cytogenet Cell Genet, 2000. PMID 10965114
  3. Characterization of ANKRA, a novel ankyrin repeat protein that interacts with the cytoplasmic domain of megalin. Rader K, et al. J Am Soc Nephrol, 2000 Dec. PMID 11095640
  4. Class II histone deacetylases confer signal responsiveness to the ankyrin-repeat proteins ANKRA2 and RFXANK. McKinsey TA, et al. Mol Biol Cell, 2006 Jan. PMID 16236793, Free PMC Article
  5. Identification of the ankyrin repeat proteins ANKRA and RFXANK as novel partners of class IIa histone deacetylases. Wang AH, et al. J Biol Chem, 2005 Aug 12. PMID 15964851

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC90650

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone deacetylase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
  
enables low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of 3M complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IGI
Inferred from Genetic Interaction
more info
 PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ankyrin repeat family A protein 2
Names
RFXANK-like protein 2
ankyrin repeat, family A (RFXANK-like), 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271388.1 → NP_001258317.1  ankyrin repeat family A protein 2 isoform a

    See identical proteins and their annotated locations for NP_001258317.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a.
    Source sequence(s)
    AC123056, AK139343, AK161446, BE952624
    Consensus CDS
    CCDS70493.1
    UniProtKB/TrEMBL
    Q3UTL3, Q6NZJ1
    Related
    ENSMUSP00000122701.2, ENSMUST00000123924.8
    Conserved Domains (3) summary
    cd00204
    Location:175 → 292
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:185 → 276
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:180 → 211
    ANK; ANK repeat [structural motif]

  2. NM_001271389.1 → NP_001258318.1  ankyrin repeat family A protein 2 isoform b

    See identical proteins and their annotated locations for NP_001258318.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and has an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (b) is longer and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK161446, BC079615
    Consensus CDS
    CCDS70492.1
    UniProtKB/TrEMBL
    Q3UTL3, Q6AXE4
    Related
    ENSMUSP00000117508.2, ENSMUST00000150352.3
    Conserved Domains (3) summary
    cd00204
    Location:175 → 292
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:185 → 276
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:180 → 211
    ANK; ANK repeat [structural motif]

  3. NM_001271390.1 → NP_001258319.1  ankyrin repeat family A protein 2 isoform c

    See identical proteins and their annotated locations for NP_001258319.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate in-frame downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus than isoform a.
    Source sequence(s)
    AK081695, AK161446, BE952624
    Consensus CDS
    CCDS70494.1
    UniProtKB/TrEMBL
    Q8C4M9
    Related
    ENSMUSP00000088915.4, ENSMUST00000091356.11
    Conserved Domains (4) summary
    COG0666
    Location:1 → 42
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:15 → 132
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:25 → 116
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:20 → 51
    ANK; ANK repeat [structural motif]

  4. NM_001271391.1 → NP_001258320.1  ankyrin repeat family A protein 2 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains multiple differences in the UTRs and coding region, compared to variant 1. These differences result in initiation of translation at an alternate in-frame downstream start codon, compared to variant 1. The encoded isoform (e) has a shorter N-terminus and a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK003438, AK161446, BE952624, BF730624
    Consensus CDS
    CCDS88506.1
    UniProtKB/TrEMBL
    A0A286YDH7
    Related
    ENSMUSP00000153417.2, ENSMUST00000226100.2
    Conserved Domains (2) summary
    sd00045
    Location:20 → 51
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:25 → 115
    Ank_2; Ankyrin repeats (3 copies)

  5. NM_001271392.1 → NP_001258321.1  ankyrin repeat family A protein 2 isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains multiple differences in the UTRs and coding region, compared to variant 1. These differences result in initiation of translation at an alternate in-frame downstream start codon, compared to variant 1. The encoded isoform (f) has a shorter N-terminus and a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK003438, AK161446, BE952624
    Consensus CDS
    CCDS88507.1
    UniProtKB/TrEMBL
    D3Z4I1
    Related
    ENSMUSP00000116590.3, ENSMUST00000150916.9
    Conserved Domains (4) summary
    COG0666
    Location:1 → 42
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:15 → 132
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:25 → 116
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:20 → 51
    ANK; ANK repeat [structural motif]

  6. NM_023472.2 → NP_075961.1  ankyrin repeat family A protein 2 isoform d

    See identical proteins and their annotated locations for NP_075961.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and has an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (d) is longer and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK161446, BC079615, BE952624, BF730624
    Consensus CDS
    CCDS26713.1
    UniProtKB/Swiss-Prot
    Q99PE2
    UniProtKB/TrEMBL
    Q3UTL3
    Related
    ENSMUSP00000022164.9, ENSMUST00000022164.16
    Conserved Domains (3) summary
    cd00204
    Location:175 → 295
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:185 → 276
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:180 → 211
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    98399584..98411262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315580.2 → XP_017171069.1  ankyrin repeat family A protein 2 isoform X1

    Conserved Domains (2) summary
    sd00045
    Location:113 → 144
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:118 → 208
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99PE2.1 GenPept UniProtKB/Swiss-Prot:Q99PE2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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