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ANKRA2 ankyrin repeat family A member 2 [ Homo sapiens (human) ]

Gene ID: 57763, updated on 21-Dec-2019

Summary

Official Symbol
ANKRA2provided by HGNC
Official Full Name
ankyrin repeat family A member 2provided by HGNC
Primary source
HGNC:HGNC:13208
See related
Ensembl:ENSG00000164331 MIM:605787
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANKRA
Expression
Ubiquitous expression in thyroid (RPKM 11.0), endometrium (RPKM 9.3) and 25 other tissues See more
Orthologs

Genomic context

See ANKRA2 in Genome Data Viewer
Location:
5q13.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (73552190..73565639, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (72848025..72861521, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene FUN14 domain containing 2 pseudogene 1 Neighboring gene basic transcription factor 3 Neighboring gene UTP15 small subunit processome component Neighboring gene uncharacterized LOC107986423 Neighboring gene Rho guanine nucleotide exchange factor 28

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
histone deacetylase binding IDA
Inferred from Direct Assay
more info
PubMed 
histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
low-density lipoprotein particle receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
regulation of protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with 3M complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ankyrin repeat family A protein 2
Names
RFXANK-like protein 2
ankyrin repeat, family A (RFXANK-like), 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023039.5NP_075526.1  ankyrin repeat family A protein 2

    See identical proteins and their annotated locations for NP_075526.1

    Status: VALIDATED

    Source sequence(s)
    AC010279, AL558295, BC012917, DB543368
    Consensus CDS
    CCDS4020.1
    UniProtKB/Swiss-Prot
    Q9H9E1
    UniProtKB/TrEMBL
    A0A024RAN7
    Related
    ENSP00000296785.3, ENST00000296785.8
    Conserved Domains (4) summary
    cd00204
    Location:176296
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:186277
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:153202
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:181212
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    73552190..73565639 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009678.2XP_016865167.1  ankyrin repeat family A protein 2 isoform X2

    Conserved Domains (3) summary
    cd00204
    Location:15135
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:25116
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:2051
    ANK; ANK repeat [structural motif]
  2. XM_005248560.3XP_005248617.1  ankyrin repeat family A protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005248617.1

    Conserved Domains (2) summary
    cd00204
    Location:108228
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:113144
    ANK; ANK repeat [structural motif]
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