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IL6R interleukin 6 receptor [ Canis lupus familiaris (dog) ]

Gene ID: 612271, updated on 18-Sep-2024

Summary

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Official Symbol
IL6Rprovided by VGNC
Official Full Name
interleukin 6 receptorprovided by VGNC
Primary source
VGNC:VGNC:41993
See related
Ensembl:ENSCAFG00845014397
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7
Exon count:
13
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 7 NC_051811.1 (42747387..42789817, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 7 NC_006589.4 (42368082..42410484, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 7 NC_049228.1 (42864074..42906503, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 7 NC_049267.1 (42526574..42569177, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 7 NC_049748.1 (42580411..42622783, complement)

Chromosome 7 - NC_051811.1Genomic Context describing neighboring genes Neighboring gene ubiquitin conjugating enzyme E2 Q1 Neighboring gene Src homology 2 domain containing E Neighboring gene uncharacterized LOC119872573 Neighboring gene uncharacterized LOC102151891 Neighboring gene ATPase phospholipid transporting 8B2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables interleukin-11 binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables interleukin-11 receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables interleukin-6 binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in interleukin-6-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
interleukin-6 receptor subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051811.1 Reference ROS_Cfam_1.0

    Range
    42747387..42789817 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038672051.1 → XP_038527979.1  interleukin-6 receptor subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0P8T7, A0A8C0PF44, A0A8I3NUE0, A0A8I3S0V0
    Related
    ENSCAFP00845020331.1, ENSCAFT00845025805.1
    Conserved Domains (4) summary
    smart00060
    Location:216 → 301
    FN3; Fibronectin type 3 domain
    cd00096
    Location:34 → 38
    Ig; Ig strand A [structural motif]
    cl11960
    Location:34 → 110
    Ig; Immunoglobulin domain
    cl21522
    Location:118 → 213
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. XM_038672053.1 → XP_038527981.1  interleukin-6 receptor subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0K604
    Conserved Domains (4) summary
    smart00060
    Location:186 → 271
    FN3; Fibronectin type 3 domain
    cd00096
    Location:4 → 8
    Ig; Ig strand A [structural motif]
    cl11960
    Location:4 → 80
    Ig; Immunoglobulin domain
    cl21522
    Location:88 → 183
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  3. XM_038672052.1 → XP_038527980.1  interleukin-6 receptor subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0K604
    Conserved Domains (4) summary
    smart00060
    Location:186 → 271
    FN3; Fibronectin type 3 domain
    cd00096
    Location:4 → 8
    Ig; Ig strand A [structural motif]
    cl11960
    Location:4 → 80
    Ig; Immunoglobulin domain
    cl21522
    Location:88 → 183
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  4. XM_038672054.1 → XP_038527982.1  interleukin-6 receptor subunit alpha isoform X3

    UniProtKB/TrEMBL
    A0A8C0P8Z8, A0A8I3NI29
    Conserved Domains (4) summary
    smart00060
    Location:216 → 301
    FN3; Fibronectin type 3 domain
    cd00096
    Location:34 → 38
    Ig; Ig strand A [structural motif]
    cl11960
    Location:34 → 110
    Ig; Immunoglobulin domain
    cl21522
    Location:118 → 213
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049267.1 Alternate UMICH_Zoey_3.1

    Range
    42526574..42569177 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038481841.1 → XP_038337769.1  interleukin-6 receptor subunit alpha isoform X1

    Conserved Domains (4) summary
    smart00060
    Location:216 → 301
    FN3; Fibronectin type 3 domain
    cd00096
    Location:34 → 38
    Ig; Ig strand A [structural motif]
    cl11960
    Location:34 → 110
    Ig; Immunoglobulin domain
    cl21522
    Location:118 → 213
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. XM_038481845.1 → XP_038337773.1  interleukin-6 receptor subunit alpha isoform X4

    Conserved Domains (4) summary
    smart00060
    Location:216 → 301
    FN3; Fibronectin type 3 domain
    cd00096
    Location:34 → 38
    Ig; Ig strand A [structural motif]
    cl11960
    Location:34 → 110
    Ig; Immunoglobulin domain
    cl21522
    Location:118 → 213
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  3. XM_038481843.1 → XP_038337771.1  interleukin-6 receptor subunit alpha isoform X2

    Conserved Domains (4) summary
    smart00060
    Location:186 → 271
    FN3; Fibronectin type 3 domain
    cd00096
    Location:4 → 8
    Ig; Ig strand A [structural motif]
    cl11960
    Location:4 → 80
    Ig; Immunoglobulin domain
    cl21522
    Location:88 → 183
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  4. XM_038481842.1 → XP_038337770.1  interleukin-6 receptor subunit alpha isoform X2

    Conserved Domains (4) summary
    smart00060
    Location:186 → 271
    FN3; Fibronectin type 3 domain
    cd00096
    Location:4 → 8
    Ig; Ig strand A [structural motif]
    cl11960
    Location:4 → 80
    Ig; Immunoglobulin domain
    cl21522
    Location:88 → 183
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  5. XM_038481844.1 → XP_038337772.1  interleukin-6 receptor subunit alpha isoform X3

    Conserved Domains (4) summary
    smart00060
    Location:216 → 301
    FN3; Fibronectin type 3 domain
    cd00096
    Location:34 → 38
    Ig; Ig strand A [structural motif]
    cl11960
    Location:34 → 110
    Ig; Immunoglobulin domain
    cl21522
    Location:118 → 213
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RNA

  1. XR_005328538.1 RNA Sequence

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049748.1 Alternate UNSW_CanFamBas_1.0

    Range
    42580411..42622783 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038607335.1 → XP_038463263.1  interleukin-6 receptor subunit alpha isoform X1

    Conserved Domains (4) summary
    smart00060
    Location:216 → 301
    FN3; Fibronectin type 3 domain
    cd00096
    Location:34 → 38
    Ig; Ig strand A [structural motif]
    cl11960
    Location:34 → 110
    Ig; Immunoglobulin domain
    cl21522
    Location:118 → 213
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. XM_038607337.1 → XP_038463265.1  interleukin-6 receptor subunit alpha isoform X2

    Conserved Domains (4) summary
    smart00060
    Location:186 → 271
    FN3; Fibronectin type 3 domain
    cd00096
    Location:4 → 8
    Ig; Ig strand A [structural motif]
    cl11960
    Location:4 → 80
    Ig; Immunoglobulin domain
    cl21522
    Location:88 → 183
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  3. XM_038607336.1 → XP_038463264.1  interleukin-6 receptor subunit alpha isoform X2

    Conserved Domains (4) summary
    smart00060
    Location:186 → 271
    FN3; Fibronectin type 3 domain
    cd00096
    Location:4 → 8
    Ig; Ig strand A [structural motif]
    cl11960
    Location:4 → 80
    Ig; Immunoglobulin domain
    cl21522
    Location:88 → 183
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  4. XM_038607338.1 → XP_038463266.1  interleukin-6 receptor subunit alpha isoform X3

    Conserved Domains (4) summary
    smart00060
    Location:216 → 301
    FN3; Fibronectin type 3 domain
    cd00096
    Location:34 → 38
    Ig; Ig strand A [structural motif]
    cl11960
    Location:34 → 110
    Ig; Immunoglobulin domain
    cl21522
    Location:118 → 213
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049228.1 Alternate UU_Cfam_GSD_1.0

    Range
    42864074..42906503 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038543225.1 → XP_038399153.1  interleukin-6 receptor subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0P8T7, A0A8C0PF44, A0A8I3NUE0, A0A8I3S0V0
    Conserved Domains (4) summary
    smart00060
    Location:216 → 301
    FN3; Fibronectin type 3 domain
    cd00096
    Location:34 → 38
    Ig; Ig strand A [structural motif]
    cl11960
    Location:34 → 110
    Ig; Immunoglobulin domain
    cl21522
    Location:118 → 213
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. XM_038543227.1 → XP_038399155.1  interleukin-6 receptor subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0K604
    Conserved Domains (4) summary
    smart00060
    Location:186 → 271
    FN3; Fibronectin type 3 domain
    cd00096
    Location:4 → 8
    Ig; Ig strand A [structural motif]
    cl11960
    Location:4 → 80
    Ig; Immunoglobulin domain
    cl21522
    Location:88 → 183
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  3. XM_038543226.1 → XP_038399154.1  interleukin-6 receptor subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0K604
    Conserved Domains (4) summary
    smart00060
    Location:186 → 271
    FN3; Fibronectin type 3 domain
    cd00096
    Location:4 → 8
    Ig; Ig strand A [structural motif]
    cl11960
    Location:4 → 80
    Ig; Immunoglobulin domain
    cl21522
    Location:88 → 183
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  4. XM_038543228.1 → XP_038399156.1  interleukin-6 receptor subunit alpha isoform X3

    UniProtKB/TrEMBL
    A0A8C0P8Z8, A0A8I3NI29
    Conserved Domains (4) summary
    smart00060
    Location:216 → 301
    FN3; Fibronectin type 3 domain
    cd00096
    Location:34 → 38
    Ig; Ig strand A [structural motif]
    cl11960
    Location:34 → 110
    Ig; Immunoglobulin domain
    cl21522
    Location:118 → 213
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006589.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    42368082..42410484 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_850012.5 → XP_855105.1  interleukin-6 receptor subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A8C0P8T7, A0A8C0PF44, A0A8I3NUE0, A0A8I3S0V0
    Conserved Domains (4) summary
    smart00060
    Location:216 → 301
    FN3; Fibronectin type 3 domain
    cd00096
    Location:34 → 38
    Ig; Ig strand A [structural motif]
    cl11960
    Location:34 → 110
    Ig; Immunoglobulin domain
    cl21522
    Location:118 → 213
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. XM_022421346.2 → XP_022277054.1  interleukin-6 receptor subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0K604
    Conserved Domains (4) summary
    smart00060
    Location:186 → 271
    FN3; Fibronectin type 3 domain
    cd00096
    Location:4 → 8
    Ig; Ig strand A [structural motif]
    cl11960
    Location:4 → 80
    Ig; Immunoglobulin domain
    cl21522
    Location:88 → 183
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  3. XM_022421344.2 → XP_022277052.1  interleukin-6 receptor subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A8C0K604
    Conserved Domains (4) summary
    smart00060
    Location:186 → 271
    FN3; Fibronectin type 3 domain
    cd00096
    Location:4 → 8
    Ig; Ig strand A [structural motif]
    cl11960
    Location:4 → 80
    Ig; Immunoglobulin domain
    cl21522
    Location:88 → 183
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  4. XM_014115387.3 → XP_013970862.1  interleukin-6 receptor subunit alpha isoform X3

    UniProtKB/TrEMBL
    A0A8C0P8Z8, A0A8I3NI29
    Conserved Domains (4) summary
    smart00060
    Location:216 → 301
    FN3; Fibronectin type 3 domain
    cd00096
    Location:34 → 38
    Ig; Ig strand A [structural motif]
    cl11960
    Location:34 → 110
    Ig; Immunoglobulin domain
    cl21522
    Location:118 → 213
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
Nucleotide Protein
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