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IL6R interleukin 6 receptor [ Homo sapiens (human) ]

Gene ID: 3570, updated on 13-Aug-2022

Summary

Official Symbol
IL6Rprovided by HGNC
Official Full Name
interleukin 6 receptorprovided by HGNC
Primary source
HGNC:HGNC:6019
See related
Ensembl:ENSG00000160712 MIM:147880; AllianceGenome:HGNC:6019
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL6Q; gp80; CD126; HIES5; IL-6R; IL6RA; IL6RQ; IL-1Ra; IL-6RA; IL6QTL; IL-6R-1
Summary
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been identified in this gene. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, Aug 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.
Expression
Ubiquitous expression in appendix (RPKM 12.7), lymph node (RPKM 12.1) and 24 other tissues See more
Orthologs
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Genomic context

See IL6R in Genome Data Viewer
Location:
1q21.3
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (154405343..154469450)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (153542427..153606601)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (154377819..154441926)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATPase phospholipid transporting 8B2 Neighboring gene RNA, U7 small nuclear 57 pseudogene Neighboring gene mitochondrial ribosomal protein S33 pseudogene 1 Neighboring gene ribosomal protein SA pseudogene 17 Neighboring gene IL6R antisense RNA 1 Neighboring gene proteasome 26S subunit, non-ATPase, 8 pseudogene 1 Neighboring gene Src homology 2 domain containing E Neighboring gene tudor domain containing 10 Neighboring gene Sharpr-MPRA regulatory region 5559

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex.
EBI GWAS Catalog
A genome-wide association study identifies protein quantitative trait loci (pQTLs).
EBI GWAS Catalog
Framingham Heart Study genome-wide association: results for pulmonary function measures.
EBI GWAS Catalog
Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease.
EBI GWAS Catalog
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
EBI GWAS Catalog
Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation.
EBI GWAS Catalog
Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.
EBI GWAS Catalog
Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.
EBI GWAS Catalog
Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.
EBI GWAS Catalog
Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
EBI GWAS Catalog
Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infected clinical samples have plasma extracellular vesicles that contain elevated CCL1 (I309), IGFBP1, CCL5 (RANTES), GMCSF, ANG, ADIPOQ (ACRP30), CSF3 (GCSF), CXCL1 (GRO), ICAM1, IL2RA, IL6R, TNFRSF1A, and TIMP1 when compared to healthy donors PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of interleukin 6 receptor (IL6R) in human B cells PubMed
Envelope surface glycoprotein gp160, precursor env Antibodies against cell surface molecules LFA-1, ICAM-1, HLA-DR, and CD28 inhibit the HIV-1 gp160-induced B cell differentiation response; gp160 also induces IL-6R and CD23 molecule expression on B cells PubMed
Tat tat Ectopic expression of HIV-1 Tat induces the production of human IL-6 (huIL-6) and its receptor (huIL-6Ra) and activates STAT3 signaling; these effects are involved in Tat-mediated activation of Kaposi's sarcoma-associated herpes virus (KSHV) replication PubMed
tat IL-6 and IL-6 receptor are upregulated in human epithelial cells by HIV-1 Tat treatment PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC104991

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ciliary neurotrophic factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to ciliary neurotrophic factor receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables interleukin-11 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables interleukin-11 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables interleukin-6 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables interleukin-6 binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to interleukin-6 receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to interleukin-6 receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in T-helper 17 cell lineage commitment IEA
Inferred from Electronic Annotation
more info
 
involved_in acute-phase response TAS
Traceable Author Statement
more info
PubMed 
involved_in ciliary neurotrophic factor-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to Gram-negative bacterium TAS
Traceable Author Statement
more info
PubMed 
involved_in endocrine pancreas development IC
Inferred by Curator
more info
PubMed 
involved_in endocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in hepatic immune response TAS
Traceable Author Statement
more info
PubMed 
involved_in interleukin-11-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in interleukin-6-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in interleukin-6-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monocyte chemotaxis IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of activation of Janus kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of chemokine production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of glomerular mesangial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of leukocyte chemotaxis TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of osteoblast differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to cytokine IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vascular endothelial growth factor production IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of ciliary neurotrophic factor receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
part_of interleukin-6 receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interleukin-6 receptor subunit alpha
Names
CD126 antigen
IL-6 receptor subunit alpha
membrane glycoprotein 80

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012087.1 RefSeqGene

    Range
    5151..69258
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000565.4NP_000556.1  interleukin-6 receptor subunit alpha isoform 1 precursor

    See identical proteins and their annotated locations for NP_000556.1

    Status: REVIEWED

    Source sequence(s)
    AA035377, AL162591, BC132684, X12830
    Consensus CDS
    CCDS1067.1
    UniProtKB/Swiss-Prot
    P08887, Q5VZ23
    UniProtKB/TrEMBL
    A0N0L5
    Related
    ENSP00000357470.3, ENST00000368485.8
    Conserved Domains (3) summary
    smart00408
    Location:3997
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:216308
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09240
    Location:118213
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  2. NM_001206866.2NP_001193795.1  interleukin-6 receptor subunit alpha isoform 3 precursor

    See identical proteins and their annotated locations for NP_001193795.1

    Status: REVIEWED

    Source sequence(s)
    AL162591
    Consensus CDS
    CCDS72927.1
    UniProtKB/Swiss-Prot
    P08887
    UniProtKB/TrEMBL
    A0A087WTB5
    Related
    ENSP00000477739.1, ENST00000622330.5
    Conserved Domains (3) summary
    cd00063
    Location:216308
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09240
    Location:118213
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    cd20939
    Location:34110
    IgC2_D1_IL-6RA; Immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as CD126); member of the C2-set of IgSF domains
  3. NM_001382769.1NP_001369698.1  interleukin-6 receptor subunit alpha isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AL162591
    Conserved Domains (3) summary
    cd00063
    Location:216308
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09240
    Location:118213
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    cd20939
    Location:34110
    IgC2_D1_IL-6RA; Immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as CD126); member of the C2-set of IgSF domains
  4. NM_001382770.1NP_001369699.1  interleukin-6 receptor subunit alpha isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AL162591
    Conserved Domains (3) summary
    cd00063
    Location:216308
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09240
    Location:118213
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    cd20939
    Location:34110
    IgC2_D1_IL-6RA; Immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as CD126); member of the C2-set of IgSF domains
  5. NM_001382771.1NP_001369700.1  interleukin-6 receptor subunit alpha isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AL162591
    Conserved Domains (3) summary
    cd00063
    Location:216308
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09240
    Location:118213
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    cd20939
    Location:34110
    IgC2_D1_IL-6RA; Immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as CD126); member of the C2-set of IgSF domains
  6. NM_001382772.1NP_001369701.1  interleukin-6 receptor subunit alpha isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AL162591
    Conserved Domains (3) summary
    cd00063
    Location:216306
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09240
    Location:118213
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    cd20939
    Location:34110
    IgC2_D1_IL-6RA; Immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as CD126); member of the C2-set of IgSF domains
  7. NM_001382773.1NP_001369702.1  interleukin-6 receptor subunit alpha isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AL162591
    Conserved Domains (3) summary
    cd00063
    Location:216308
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09240
    Location:118213
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
    cd20939
    Location:34110
    IgC2_D1_IL-6RA; Immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as CD126); member of the C2-set of IgSF domains
  8. NM_001382774.1NP_001369703.1  interleukin-6 receptor subunit alpha isoform 9 precursor

    Status: REVIEWED

    Source sequence(s)
    AL162591
    Conserved Domains (2) summary
    cd00063
    Location:96188
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:4093
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  9. NM_181359.3NP_852004.1  interleukin-6 receptor subunit alpha isoform 2 precursor

    See identical proteins and their annotated locations for NP_852004.1

    Status: REVIEWED

    Source sequence(s)
    AA035377, AL162591, BC089410
    Consensus CDS
    CCDS1068.1
    UniProtKB/Swiss-Prot
    P08887
    Related
    ENSP00000340589.4, ENST00000344086.8
    Conserved Domains (3) summary
    smart00408
    Location:3997
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:216308
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09240
    Location:118213
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    154405343..154469450
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001199.2XP_016856688.1  interleukin-6 receptor subunit alpha isoform X1

  2. XM_047419655.1XP_047275611.1  interleukin-6 receptor subunit alpha isoform X6

  3. XM_005245139.2XP_005245196.1  interleukin-6 receptor subunit alpha isoform X8

    Conserved Domains (4) summary
    smart00408
    Location:3997
    IGc2; Immunoglobulin C-2 Type
    smart00060
    Location:216277
    FN3; Fibronectin type 3 domain
    smart00410
    Location:33110
    IG_like; Immunoglobulin like
    pfam09240
    Location:118213
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  4. XM_047419654.1XP_047275610.1  interleukin-6 receptor subunit alpha isoform X5

  5. XM_047419657.1XP_047275613.1  interleukin-6 receptor subunit alpha isoform X9

  6. XM_047419656.1XP_047275612.1  interleukin-6 receptor subunit alpha isoform X7

  7. XM_047419648.1XP_047275604.1  interleukin-6 receptor subunit alpha isoform X2

  8. XM_047419649.1XP_047275605.1  interleukin-6 receptor subunit alpha isoform X3

  9. XM_047419650.1XP_047275606.1  interleukin-6 receptor subunit alpha isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    153542427..153606601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)