IL6R interleukin 6 receptor [Homo sapiens (human)] - Gene

Summary

Official Symbol: IL6Rprovided by HGNC
Official Full Name: interleukin 6 receptorprovided by HGNC
Primary source: HGNC:HGNC:6019
See related: Ensembl:ENSG00000160712 MIM:147880; AllianceGenome:HGNC:6019
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IL6Q; gp80; CD126; HIES5; IL-6R; IL6RA; IL6RQ; IL-1Ra; IL-6RA; IL6QTL; IL-6R-1
Summary: This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been identified in this gene. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, Aug 2020]
Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.
Expression: Ubiquitous expression in appendix (RPKM 12.7), lymph node (RPKM 12.1) and 24 other tissues See more
Orthologs: all
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Try the new Transcripts and proteins table

Genomic context

Location:: 1q21.3

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (154405343..154469450)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (153542427..153606601)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (154377819..154441926)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL-6R (trans-signaling) is a key regulator of reverse cholesterol transport in lipid-laden macrophages.
Title: IL-6R (trans-signaling) is a key regulator of reverse cholesterol transport in lipid-laden macrophages.
Genetic variations of IL10 and IL6R genes in acute anterior uveitis in Han Chinese.
Title: Genetic variations of IL10 and IL6R genes in acute anterior uveitis in Han Chinese.
Causal relationship of interleukin-6 and its receptor on sarcopenia traits using mendelian randomization.
Title: Causal relationship of interleukin-6 and its receptor on sarcopenia traits using mendelian randomization.
The Possible Association of IL-6R Gene Polymorphisms in the Development of Diabetic Nephropathy.
Title: The Possible Association of IL-6R Gene Polymorphisms in the Development of Diabetic Nephropathy.
No Association of Polymorphisms in the Genes Encoding Interleukin-6 and Interleukin-6 Receptor Subunit Alpha with the Risk of Keloids in Polish Patients.
Title: No Association of Polymorphisms in the Genes Encoding Interleukin-6 and Interleukin-6 Receptor Subunit Alpha with the Risk of Keloids in Polish Patients.
Heterogeneous associations between interleukin-6 receptor variants and phenotypes across ancestries and implications for therapy.
Title: Heterogeneous associations between interleukin-6 receptor variants and phenotypes across ancestries and implications for therapy.
Role of interleukin-6 and endothelin-1 receptors in enhanced melanocyte dendricity of facial spots and suppression of their ligands by niacinamide and tranexamic acid.
Title: Role of interleukin-6 and endothelin-1 receptors in enhanced melanocyte dendricity of facial spots and suppression of their ligands by niacinamide and tranexamic acid.
Associations between serum estradiol and IL-6/sIL-6R/sgp130 complex in female patients with major depressive disorder.
Title: Associations between serum estradiol and IL-6/sIL-6R/sgp130 complex in female patients with major depressive disorder.
Role of interleukin 6 and its soluble receptor on the diffusion barrier dysfunction of alveolar tissue.
Title: Role of interleukin 6 and its soluble receptor on the diffusion barrier dysfunction of alveolar tissue.
Possible Role of IL-6R/STAT3/MiRNA-34a Feedback Loop in Osteosarcoma.
Title: Possible Role of IL-6R/STAT3/MiRNA-34a Feedback Loop in Osteosarcoma.

Submit: New GeneRIF Correction See all GeneRIFs (393)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Hyper-IgE recurrent infection syndrome 5, autosomal recessive MedGen: C5394550 OMIM: 618944 GeneReviews: Not available	not available
Interleukin 6, serum level of, quantitative trait locus MedGen: C3540094 OMIM: 614752 GeneReviews: Not available	not available
Soluble interleukin-6 receptor, serum level of, quantitative trait locus MedGen: C3553493 OMIM: 614689 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide association study identifies protein quantitative trait loci (pQTLs). EBI GWAS Catalog EBI GWAS CatalogPubMed
Framingham Heart Study genome-wide association: results for pulmonary function measures. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetics of rheumatoid arthritis contributes to biology and drug discovery. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of IL6R and chromosome 11q13.5 as risk loci for asthma. EBI GWAS Catalog EBI GWAS CatalogPubMed
Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis of genome-wide association studies in &gt;80 000 subjects identifies multiple loci for C-reactive protein levels. EBI GWAS Catalog EBI GWAS CatalogPubMed
Multiethnic meta-analysis of genome-wide association studies in &gt;100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interaction	Pubs
HIV-1 infected clinical samples have plasma extracellular vesicles that contain elevated CCL1 (I309), IGFBP1, CCL5 (RANTES), GMCSF, ANG, ADIPOQ (ACRP30), CSF3 (GCSF), CXCL1 (GRO), ICAM1, IL2RA, IL6R, TNFRSF1A, and TIMP1 when compared to healthy donors	PubMed

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 upregulates the expression of interleukin 6 receptor (IL6R) in human B cells	PubMed
Envelope surface glycoprotein gp160, precursor	env	Antibodies against cell surface molecules LFA-1, ICAM-1, HLA-DR, and CD28 inhibit the HIV-1 gp160-induced B cell differentiation response; gp160 also induces IL-6R and CD23 molecule expression on B cells	PubMed
Tat	tat	Ectopic expression of HIV-1 Tat induces the production of human IL-6 (huIL-6) and its receptor (huIL-6Ra) and activates STAT3 signaling; these effects are involved in Tat-mediated activation of Kaposi's sarcoma-associated herpes virus (KSHV) replication	PubMed
	tat	IL-6 and IL-6 receptor are upregulated in human epithelial cells by HIV-1 Tat treatment	PubMed

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

GDB:434012 (e-PCR)
- UniSTS:157204

GDB:353581 (e-PCR)
- UniSTS:156707

PMC119947P1 (e-PCR)
- UniSTS:270376

L17705 (e-PCR)
- UniSTS:66091

SHGC-34808 (e-PCR)
- UniSTS:34124

L18426 (e-PCR)
- UniSTS:34648

D10S16 (e-PCR)
- UniSTS:155756

D1S2375 (e-PCR)
- UniSTS:22125

D1S1423 (e-PCR)
- UniSTS:149619

RH69094 (e-PCR)
- UniSTS:42367

IL6R_1457 (e-PCR)
- UniSTS:277379

L17877 (e-PCR)
- UniSTS:61334

RH16347 (e-PCR)
- UniSTS:77754

NoName (e-PCR)
- UniSTS:494542

GDB:386402 (e-PCR)
- UniSTS:157147

PMC150666P1 (e-PCR)
- UniSTS:271068

D1S1816E (e-PCR)
- UniSTS:150775

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ciliary neurotrophic factor binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to ciliary neurotrophic factor receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cytokine receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables interleukin-11 binding	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-11 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-6 binding	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-6 binding	IEA Inferred from Electronic Annotation more info
enables interleukin-6 binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to interleukin-6 receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables interleukin-6 receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables interleukin-6 receptor activity	IEA Inferred from Electronic Annotation more info
contributes_to interleukin-6 receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T-helper 17 cell lineage commitment	IEA Inferred from Electronic Annotation more info
involved_in T-helper 17 cell lineage commitment	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in T-helper 17 cell lineage commitment	NAS Non-traceable Author Statement more info	PubMed
involved_in acute-phase response	TAS Traceable Author Statement more info	PubMed
involved_in autocrine signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in autocrine signaling	NAS Non-traceable Author Statement more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway via STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ciliary neurotrophic factor-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytokine-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to Gram-negative bacterium	TAS Traceable Author Statement more info	PubMed
involved_in defense response to Gram-positive bacterium	NAS Non-traceable Author Statement more info	PubMed
involved_in developmental process	IEA Inferred from Electronic Annotation more info
involved_in endocrine pancreas development	IC Inferred by Curator more info	PubMed
involved_in endocrine pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extrinsic apoptotic signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in hepatic immune response	TAS Traceable Author Statement more info	PubMed
involved_in inflammatory response	NAS Non-traceable Author Statement more info	PubMed
involved_in interleukin-11-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-6-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in interleukin-6-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-6-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interleukin-6-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in interleukin-6-mediated signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in monocyte chemotaxis	IC Inferred by Curator more info	PubMed
involved_in negative regulation of collagen biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of fat cell proliferation	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of interleukin-8 production	NAS Non-traceable Author Statement more info	PubMed
involved_in neutrophil mediated immunity	TAS Traceable Author Statement more info	PubMed
involved_in paracrine signaling	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of chemokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of glomerular mesangial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of leukocyte chemotaxis	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of osteoblast differentiation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of positive regulation of platelet aggregation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of insulin secretion	NAS Non-traceable Author Statement more info	PubMed
involved_in response to cytokine	IDA Inferred from Direct Assay more info	PubMed
involved_in vascular endothelial growth factor production	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of ciliary neurotrophic factor receptor complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
part_of interleukin-6 receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of interleukin-6 receptor complex	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interleukin-6 receptor subunit alpha

Names: CD126 antigen; IL-6 receptor subunit alpha; membrane glycoprotein 80

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012087.1 RefSeqGene

Range

5151..69258

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000565.4 → NP_000556.1 interleukin-6 receptor subunit alpha isoform 1 precursor

See identical proteins and their annotated locations for NP_000556.1

Status: REVIEWED

Source sequence(s)

AA035377, AL162591, BC132684, X12830

Consensus CDS

CCDS1067.1

UniProtKB/Swiss-Prot

A8KAE8, B2R6V4, P08887, Q16202, Q53EQ7, Q5FWG2, Q5VZ23

UniProtKB/TrEMBL

A0N0L5

Related

ENSP00000357470.3, ENST00000368485.8

Conserved Domains (3) summary

smart00408
Location:39 → 97

IGc2; Immunoglobulin C-2 Type

cd00063
Location:216 → 308

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam09240
Location:118 → 213

IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
NM_001206866.2 → NP_001193795.1 interleukin-6 receptor subunit alpha isoform 3 precursor

See identical proteins and their annotated locations for NP_001193795.1

Status: REVIEWED

Source sequence(s)

AL162591

Consensus CDS

CCDS72927.1

UniProtKB/TrEMBL

A0A087WTB5

Related

ENSP00000477739.1, ENST00000622330.5

Conserved Domains (3) summary

cd00063
Location:216 → 308

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam09240
Location:118 → 213

IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

cd20939
Location:34 → 110

IgC2_D1_IL-6RA; Immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as CD126); member of the C2-set of IgSF domains
NM_001382769.1 → NP_001369698.1 interleukin-6 receptor subunit alpha isoform 4 precursor

Status: REVIEWED

Source sequence(s)

AL162591

Related

ENSP00000528565.1, ENST00000858506.1

Conserved Domains (3) summary

cd00063
Location:216 → 308

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam09240
Location:118 → 213

IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

cd20939
Location:34 → 110

IgC2_D1_IL-6RA; Immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as CD126); member of the C2-set of IgSF domains
NM_001382770.1 → NP_001369699.1 interleukin-6 receptor subunit alpha isoform 5 precursor

Status: REVIEWED

Source sequence(s)

AL162591

Related

ENSP00000528564.1, ENST00000858505.1

Conserved Domains (3) summary

cd00063
Location:216 → 308

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam09240
Location:118 → 213

IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

cd20939
Location:34 → 110

IgC2_D1_IL-6RA; Immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as CD126); member of the C2-set of IgSF domains
NM_001382771.1 → NP_001369700.1 interleukin-6 receptor subunit alpha isoform 6 precursor

Status: REVIEWED

Source sequence(s)

AL162591

Conserved Domains (3) summary

cd00063
Location:216 → 308

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam09240
Location:118 → 213

IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

cd20939
Location:34 → 110

IgC2_D1_IL-6RA; Immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as CD126); member of the C2-set of IgSF domains
NM_001382772.1 → NP_001369701.1 interleukin-6 receptor subunit alpha isoform 7 precursor

Status: REVIEWED

Source sequence(s)

AL162591

Conserved Domains (3) summary

cd00063
Location:216 → 306

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam09240
Location:118 → 213

IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

cd20939
Location:34 → 110

IgC2_D1_IL-6RA; Immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as CD126); member of the C2-set of IgSF domains
NM_001382773.1 → NP_001369702.1 interleukin-6 receptor subunit alpha isoform 8 precursor

Status: REVIEWED

Source sequence(s)

AL162591

Conserved Domains (3) summary

cd00063
Location:216 → 308

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam09240
Location:118 → 213

IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

cd20939
Location:34 → 110

IgC2_D1_IL-6RA; Immunoglobulin-like domain D1 of interleukin-6 receptor alpha-chain (IL-6RA, also known as CD126); member of the C2-set of IgSF domains
NM_001382774.1 → NP_001369703.1 interleukin-6 receptor subunit alpha isoform 9 precursor

Status: REVIEWED

Source sequence(s)

AL162591

Conserved Domains (2) summary

cd00063
Location:96 → 188

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:40 → 93

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_181359.3 → NP_852004.1 interleukin-6 receptor subunit alpha isoform 2 precursor

See identical proteins and their annotated locations for NP_852004.1

Status: REVIEWED

Source sequence(s)

AA035377, AL162591, BC089410

Consensus CDS

CCDS1068.1

UniProtKB/Swiss-Prot

P08887

Related

ENSP00000340589.4, ENST00000344086.8

Conserved Domains (3) summary

smart00408
Location:39 → 97

IGc2; Immunoglobulin C-2 Type

cd00063
Location:216 → 308

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam09240
Location:118 → 213

IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

154405343..154469450

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017001199.2 → XP_016856688.1 interleukin-6 receptor subunit alpha isoform X1
XM_047419655.1 → XP_047275611.1 interleukin-6 receptor subunit alpha isoform X6
XM_005245139.2 → XP_005245196.1 interleukin-6 receptor subunit alpha isoform X8

Conserved Domains (4) summary

smart00408
Location:39 → 97

IGc2; Immunoglobulin C-2 Type

smart00060
Location:216 → 277

FN3; Fibronectin type 3 domain

smart00410
Location:33 → 110

IG_like; Immunoglobulin like

pfam09240
Location:118 → 213

IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
XM_047419654.1 → XP_047275610.1 interleukin-6 receptor subunit alpha isoform X5
XM_047419657.1 → XP_047275613.1 interleukin-6 receptor subunit alpha isoform X9
XM_047419656.1 → XP_047275612.1 interleukin-6 receptor subunit alpha isoform X7
XM_047419648.1 → XP_047275604.1 interleukin-6 receptor subunit alpha isoform X2
XM_047419649.1 → XP_047275605.1 interleukin-6 receptor subunit alpha isoform X3
XM_047419650.1 → XP_047275606.1 interleukin-6 receptor subunit alpha isoform X4

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

153542427..153606601

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054336391.1 → XP_054192366.1 interleukin-6 receptor subunit alpha isoform X1
XM_054336401.1 → XP_054192376.1 interleukin-6 receptor subunit alpha isoform X6
XM_054336405.1 → XP_054192380.1 interleukin-6 receptor subunit alpha isoform X8
XM_054336403.1 → XP_054192378.1 interleukin-6 receptor subunit alpha isoform X7
XM_054336393.1 → XP_054192368.1 interleukin-6 receptor subunit alpha isoform X2
XM_054336395.1 → XP_054192370.1 interleukin-6 receptor subunit alpha isoform X3
XM_054336397.1 → XP_054192372.1 interleukin-6 receptor subunit alpha isoform X4
XM_054336398.1 → XP_054192373.1 interleukin-6 receptor subunit alpha isoform X14
XM_054336402.1 → XP_054192377.1 interleukin-6 receptor subunit alpha isoform X17
XM_054336390.1 → XP_054192365.1 interleukin-6 receptor subunit alpha isoform X10
XM_054336399.1 → XP_054192374.1 interleukin-6 receptor subunit alpha isoform X15
XM_054336400.1 → XP_054192375.1 interleukin-6 receptor subunit alpha isoform X16
XM_054336406.1 → XP_054192381.1 interleukin-6 receptor subunit alpha isoform X19
XM_054336392.1 → XP_054192367.1 interleukin-6 receptor subunit alpha isoform X11
XM_054336404.1 → XP_054192379.1 interleukin-6 receptor subunit alpha isoform X18
XM_054336394.1 → XP_054192369.1 interleukin-6 receptor subunit alpha isoform X12
XM_054336396.1 → XP_054192371.1 interleukin-6 receptor subunit alpha isoform X13