Il6ra interleukin 6 receptor, alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il6raprovided by MGI
Official Full Name: interleukin 6 receptor, alphaprovided by MGI
Primary source: MGI:MGI:105304
See related: Ensembl:ENSMUSG00000027947 AllianceGenome:MGI:105304
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Il6r; CD126; IL-6R; IL-6RA; IL-6R-alpha
Summary: Enables interleukin-6 receptor activity. Involved in T-helper 17 cell lineage commitment and interleukin-6-mediated signaling pathway. Part of interleukin-6 receptor complex. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system; and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; hyper IgE syndrome; obesity; and stomach cancer. Orthologous to human IL6R (interleukin 6 receptor). [provided by Alliance of Genome Resources, Jul 2025]
Expression: Broad expression in spleen adult (RPKM 12.8), mammary gland adult (RPKM 10.6) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 39.19 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (89776631..89820503, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (89869324..89913196, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gp130-HIF1alpha axis-induced vascular damage is prevented by the short-term inhibition of IL-6 receptor signaling.
Title: Gp130-HIF1α axis-induced vascular damage is prevented by the short-term inhibition of IL-6 receptor signaling.
Diabetic Muller-Glial-Cell-Specific Il6ra Knockout Mice Exhibit Accelerated Retinal Functional Decline and Thinning of the Inner Nuclear Layer.
Title: Diabetic Müller-Glial-Cell-Specific Il6ra Knockout Mice Exhibit Accelerated Retinal Functional Decline and Thinning of the Inner Nuclear Layer.
Interleukin 6 receptor is not directly involved in regulation of body weight in diet-induced obesity with and without physical exercise.
Title: Interleukin 6 receptor is not directly involved in regulation of body weight in diet-induced obesity with and without physical exercise.
Central deficiency of IL-6Ra in mice impairs glucose-stimulated insulin secretion.
Title: Central deficiency of IL-6Ra in mice impairs glucose-stimulated insulin secretion.
IL-6R/Signal Transducer and Activator of Transcription 3 Signaling in Keratinocytes rather than in T Cells Induces Psoriasis-Like Dermatitis in Mice.
Title: IL-6R/Signal Transducer and Activator of Transcription 3 Signaling in Keratinocytes rather than in T Cells Induces Psoriasis-Like Dermatitis in Mice.
CD146 Associates with Gp130 to Control a Macrophage Pro-inflammatory Program That Regulates the Metabolic Response to Obesity.
Title: CD146 Associates with Gp130 to Control a Macrophage Pro-inflammatory Program That Regulates the Metabolic Response to Obesity.
MiR-125-5p/IL-6R axis regulates macrophage inflammatory response and intestinal epithelial cell apoptosis in ulcerative colitis through JAK1/STAT3 and NF-kappaB pathway.
Title: MiR-125-5p/IL-6R axis regulates macrophage inflammatory response and intestinal epithelial cell apoptosis in ulcerative colitis through JAK1/STAT3 and NF-κB pathway.
Interleukin-6 receptor alpha and CD27 discriminate intratumoral T helper 17 subpopulations with distinct functional properties in a mouse lung cancer model.
Title: Interleukin-6 receptor alpha and CD27 discriminate intratumoral T helper 17 subpopulations with distinct functional properties in a mouse lung cancer model.
Preclinical development of CD126 CAR-T cells with broad antitumor activity.
Title: Preclinical development of CD126 CAR-T cells with broad antitumor activity.
Extracellular CIRP induces macrophage endotoxin tolerance through IL-6R-mediated STAT3 activation.
Title: Extracellular CIRP induces macrophage endotoxin tolerance through IL-6R-mediated STAT3 activation.

Submit: New GeneRIF Correction See all GeneRIFs (59)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (15)
Gene trapped (1)
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Il6ra (e-PCR), detects polymorphism
- UniSTS:265227

px-50g7 (e-PCR)
- UniSTS:257891

Il6ra (e-PCR), detects polymorphism
- UniSTS:259183

X51975 (e-PCR)
- UniSTS:178862

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ciliary neurotrophic factor binding	IEA Inferred from Electronic Annotation more info
enables ciliary neurotrophic factor binding	ISO Inferred from Sequence Orthology more info
contributes_to ciliary neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
contributes_to ciliary neurotrophic factor receptor activity	ISO Inferred from Sequence Orthology more info
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info
enables cytokine receptor activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables interleukin-11 binding	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-11 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-6 binding	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-6 binding	IDA Inferred from Direct Assay more info	PubMed
enables interleukin-6 binding	IEA Inferred from Electronic Annotation more info
enables interleukin-6 binding	ISO Inferred from Sequence Orthology more info
enables interleukin-6 receptor activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to interleukin-6 receptor activity	IEA Inferred from Electronic Annotation more info
contributes_to interleukin-6 receptor activity	ISO Inferred from Sequence Orthology more info
contributes_to interleukin-6 receptor binding	IEA Inferred from Electronic Annotation more info
contributes_to interleukin-6 receptor binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T-helper 17 cell lineage commitment	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway via STAT	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway via STAT	ISO Inferred from Sequence Orthology more info
involved_in ciliary neurotrophic factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ciliary neurotrophic factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in developmental growth	ISO Inferred from Sequence Orthology more info
involved_in developmental process	IEA Inferred from Electronic Annotation more info
involved_in endocrine pancreas development	IEA Inferred from Electronic Annotation more info
involved_in endocrine pancreas development	ISO Inferred from Sequence Orthology more info
involved_in interleukin-11-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-6-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within interleukin-6-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-6-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-6-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within interleukin-6-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-6-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glomerular mesangial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glomerular mesangial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of platelet aggregation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in response to cytokine	IEA Inferred from Electronic Annotation more info
involved_in response to cytokine	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor production	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor production	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
part_of ciliary neurotrophic factor receptor complex	IEA Inferred from Electronic Annotation more info
part_of ciliary neurotrophic factor receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of interleukin-6 receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of interleukin-6 receptor complex	IEA Inferred from Electronic Annotation more info
part_of interleukin-6 receptor complex	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interleukin-6 receptor subunit alpha

Names: IL-6 receptor alpha chain; IL-6 receptor subunit alpha; IL-6R 1; IL-6R subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310676.1 → NP_001297605.1 interleukin-6 receptor subunit alpha isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC102392, AK082270, AK141197, BQ033304

Consensus CDS

CCDS79954.1

UniProtKB/TrEMBL

A0A0G2JGF1, Q3URV7

Related

ENSMUSP00000143541.2, ENSMUST00000197679.5

Conserved Domains (4) summary

smart00060
Location:213 → 290

FN3; Fibronectin type 3 domain

smart00410
Location:33 → 108

IG_like; Immunoglobulin like

pfam00047
Location:30 → 98

ig; Immunoglobulin domain

pfam09240
Location:114 → 210

IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
NM_010559.3 → NP_034689.2 interleukin-6 receptor subunit alpha isoform 1 precursor

See identical proteins and their annotated locations for NP_034689.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC102392, AK082270, AK141197, BQ033304

Consensus CDS

CCDS38496.1

UniProtKB/Swiss-Prot

P22272

UniProtKB/TrEMBL

Q3URV7

Related

ENSMUSP00000029559.7, ENSMUST00000029559.7

Conserved Domains (4) summary

smart00060
Location:213 → 290

FN3; Fibronectin type 3 domain

smart00410
Location:33 → 108

IG_like; Immunoglobulin like

pfam00047
Location:30 → 98

ig; Immunoglobulin domain

pfam09240
Location:114 → 210

IL6Ra-bind; Interleukin-6 receptor alpha chain, binding