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Il6ra interleukin 6 receptor, alpha [ Mus musculus (house mouse) ]

Gene ID: 16194, updated on 5-Jan-2023

Summary

Official Symbol
Il6raprovided by MGI
Official Full Name
interleukin 6 receptor, alphaprovided by MGI
Primary source
MGI:MGI:105304
See related
Ensembl:ENSMUSG00000027947 AllianceGenome:MGI:105304
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Il6r; CD126; IL-6R; IL-6RA; IL-6R-alpha
Summary
Enables interleukin-6 binding activity and interleukin-6 receptor activity. Involved in T-helper 17 cell lineage commitment and interleukin-6-mediated signaling pathway. Located in cell surface. Part of interleukin-6 receptor complex. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system; and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; hyper IgE syndrome; obesity; and stomach cancer. Orthologous to human IL6R (interleukin 6 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 12.8), mammary gland adult (RPKM 10.6) and 20 other tissues See more
Orthologs
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Genomic context

See Il6ra in Genome Data Viewer
Location:
3 F1; 3 39.19 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89776631..89820503, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89869324..89913196, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 8969 Neighboring gene src homology 2 domain-containing transforming protein E Neighboring gene ATPase, class I, type 8B, member 2 Neighboring gene aquaporin 10, pseudogene Neighboring gene predicted gene, 24046

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (8)  1 citation
  • Endonuclease-mediated (8) 

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC30256

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ciliary neurotrophic factor binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to ciliary neurotrophic factor receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-11 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables interleukin-11 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables interleukin-6 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables interleukin-6 binding ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-6 receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to interleukin-6 receptor activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to interleukin-6 receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in T-helper 17 cell lineage commitment IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ciliary neurotrophic factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in developmental growth ISO
Inferred from Sequence Orthology
more info
 
involved_in endocrine pancreas development ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-6-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within interleukin-6-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in interleukin-6-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in interleukin-6-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of activation of Janus kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of activation of Janus kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glomerular mesangial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of platelet aggregation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tyrosine phosphorylation of STAT protein IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
involved_in response to cytokine ISO
Inferred from Sequence Orthology
more info
 
involved_in vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of ciliary neurotrophic factor receptor complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of interleukin-6 receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of interleukin-6 receptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
interleukin-6 receptor subunit alpha
Names
IL-6 receptor alpha chain
IL-6 receptor subunit alpha
IL-6R 1
IL-6R subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310676.1NP_001297605.1  interleukin-6 receptor subunit alpha isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC102392, AK082270, AK141197, BQ033304
    Consensus CDS
    CCDS79954.1
    UniProtKB/TrEMBL
    A0A0G2JGF1, Q3URV7
    Related
    ENSMUSP00000143541.2, ENSMUST00000197679.5
    Conserved Domains (4) summary
    smart00060
    Location:213290
    FN3; Fibronectin type 3 domain
    smart00410
    Location:33108
    IG_like; Immunoglobulin like
    pfam00047
    Location:3098
    ig; Immunoglobulin domain
    pfam09240
    Location:114210
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding
  2. NM_010559.3NP_034689.2  interleukin-6 receptor subunit alpha isoform 1 precursor

    See identical proteins and their annotated locations for NP_034689.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC102392, AK082270, AK141197, BQ033304
    Consensus CDS
    CCDS38496.1
    UniProtKB/Swiss-Prot
    P22272
    UniProtKB/TrEMBL
    Q3URV7
    Related
    ENSMUSP00000029559.7, ENSMUST00000029559.7
    Conserved Domains (4) summary
    smart00060
    Location:213290
    FN3; Fibronectin type 3 domain
    smart00410
    Location:33108
    IG_like; Immunoglobulin like
    pfam00047
    Location:3098
    ig; Immunoglobulin domain
    pfam09240
    Location:114210
    IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89776631..89820503 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)