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ipo8 importin 8 [ Danio rerio (zebrafish) ]

Gene ID: 555520, updated on 17-Sep-2024

Summary

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Official Symbol
ipo8provided by ZNC
Official Full Name
importin 8provided by ZNC
Primary source
ZFIN:ZDB-GENE-060503-3
See related
Ensembl:ENSDARG00000058159 AllianceGenome:ZFIN:ZDB-GENE-060503-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Imp8; si:ch211-116i17.1
Summary
Predicted to be involved in protein import into nucleus. Predicted to act upstream of or within intracellular protein transport. Predicted to be active in cytosol and nuclear envelope. Orthologous to human IPO8 (importin 8). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 4
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (9360700..9389364)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (9359724..9388446)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene SLIT-ROBO Rho GTPase activating protein 1b Neighboring gene uncharacterized LOC101884274 Neighboring gene KICSTOR subunit 2 Neighboring gene transmembrane O-mannosyltransferase targeting cadherins 1 Neighboring gene ovochymase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Defining the gene repertoire and spatiotemporal expression profiles of adhesion G protein-coupled receptors in zebrafish. Harty BL, et al. BMC Genomics, 2015 Feb 8. PMID 25715737, Free PMC Article
  2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC198203

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
importin-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044334.2 → NP_001037799.2  importin-8

    See identical proteins and their annotated locations for NP_001037799.2

    Status: PROVISIONAL

    Source sequence(s)
    BC171476
    UniProtKB/Swiss-Prot
    A5WW24
    UniProtKB/TrEMBL
    A0A8M1N965, B7ZV68
    Related
    ENSDARP00000129258.2, ENSDART00000156946.3
    Conserved Domains (2) summary
    COG5656
    Location:6 → 1002
    SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]
    pfam03810
    Location:22 → 101
    IBN_N; Importin-beta N-terminal domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    9360700..9389364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005164582.5 → XP_005164639.1  importin-8 isoform X1

    UniProtKB/Swiss-Prot
    A5WW24
    UniProtKB/TrEMBL
    A0A2R8RMT5, A0A8M2BBQ6
    Related
    ENSDARP00000148856.1, ENSDART00000189971.1
    Conserved Domains (2) summary
    COG5656
    Location:15 → 1005
    SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]
    pfam03810
    Location:22 → 101
    IBN_N; Importin-beta N-terminal domain

  2. XM_021475018.2 → XP_021330693.1  importin-8 isoform X2

    UniProtKB/Swiss-Prot
    A5WW24
    UniProtKB/TrEMBL
    A0A8M9PUE9
    Conserved Domains (1) summary
    cl27876
    Location:15 → 875
    Cse1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A5WW24.1 GenPept UniProtKB/Swiss-Prot:A5WW24

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